ABSTRACT
We report the case of an adolescent girl with anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis who presented with focal seizures and hemichorea, followed by agitation, speech disturbance, mutism, and autonomic dysfunction. The institution of immunotherapy and removal of an ovarian cystadenofibroma led to full resolution of her symptoms with disappearance of serum NMDAR antibodies. This is the first report linking ovarian cystadenofibroma to anti-NMDAR encephalitis.
Subject(s)
Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications , Cystadenofibroma/complications , Ovarian Neoplasms/complications , Seizures/etiology , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/therapy , Cystadenofibroma/therapy , Female , Humans , Immunotherapy , Ovarian Neoplasms/therapy , Seizures/therapy , Treatment Outcome , Young AdultABSTRACT
Ovarian serous cystadenofibromas are benign neoplasms that sometimes have focal areas of borderline serous tumor and rarely have been associated with epithelial proliferations in the peritoneum, resembling implants. We are reporting 2 cases of ovarian serous cystadenofibromas with serous peritoneal lesions of higher grade than the ovarian tumor: 1 case had a serous carcinoma and another 1 a serous borderline tumor.
