1.
Rev Esp Anestesiol Reanim (Engl Ed)
; 66(9): 490-491, 2019 Nov.
Article
in English, Spanish
| MEDLINE
| ID: mdl-31627934
Subject(s)
Anesthesiologists , Delayed Emergence from Anesthesia/chemically induced , Neuromuscular Depolarizing Agents/adverse effects , Succinylcholine/adverse effects , Adult , Anesthesia/methods , Butyrylcholinesterase/blood , Butyrylcholinesterase/genetics , Delayed Emergence from Anesthesia/enzymology , Humans , Male
2.
A A Case Rep
; 7(11): 243-246, 2016 Dec 01.
Article
in English
| MEDLINE
| ID: mdl-27749294
ABSTRACT
This case report describes a 71-year-old woman who experienced unusual delayed emergence from propofol, which lasted for 3 hours and resulted in admission to the intensive care unit. Because genetic variations of propofol-metabolizing enzymes are proposed to be causal factors, we explored genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) and uridine 5'-diphospho-glucuronosyltransferase 1A9 (UGT1A9). Suggested high-risk factors (advanced age, CYP2B6 516 G/T, and UGT1A9 I399 C/C) were observed in this case of delayed propofol metabolism. Therefore, genetic variants involved in propofol metabolism should be considered in unexplained delayed emergence.
