ABSTRACT
Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDCT) histology is similar to that of the classical follicular dendritic cell (FDC) tumor, but, in addition, the inflammatory component is quite prominent. We report a case of IPT-like FDCT of the spleen by abdominal CT and 18F-FDG PET/CT. Abdominal CT showed a low-density, round, well-circumscribed defined mass in spleen, and the mass showed a high metabolism rate on 18F-FDG PET/CT.
Subject(s)
Dendritic Cells, Follicular/diagnostic imaging , Multimodal Imaging , Positron-Emission Tomography , Splenic Neoplasms/diagnostic imaging , Tomography, X-Ray Computed , Adult , Fluorodeoxyglucose F18 , Humans , Inflammation/diagnostic imaging , Male , Splenic Neoplasms/immunologyABSTRACT
Follicular dendritic cell sarcoma is a rare neoplasm that originates from follicular dendritic cells in lymphoid follicles. This disease usually involves the lymph nodes, and especially the head and neck area. Rarely, extranodal sites may be affected, including tonsil, the oral cavity, liver, spleen and the gastrointestinal tract. We report here on the imaging findings of follicular dendritic cell sarcoma of the abdomen that involved the retroperitoneal lymph nodes and colon. It shows as a well-defined, enhancing homogenous mass with internal necrosis and regional lymphadenopathy.
Subject(s)
Abdominal Neoplasms/diagnostic imaging , Colonic Neoplasms/diagnostic imaging , Dendritic Cell Sarcoma, Follicular/diagnostic imaging , Abdomen/diagnostic imaging , Abdominal Neoplasms/complications , Abdominal Pain/etiology , Aged , Colon/diagnostic imaging , Colonic Neoplasms/complications , Dendritic Cell Sarcoma, Follicular/complications , Dendritic Cells, Follicular/diagnostic imaging , Diagnosis, Differential , Dyspepsia/etiology , Female , Gastrointestinal Hemorrhage/etiology , Humans , Lymph Nodes , Male , Middle Aged , Radiography, Abdominal/methods , Retroperitoneal Space/diagnostic imaging , Tomography, X-Ray Computed/methods , UltrasonographyABSTRACT
Follicular dendritic cell sarcoma is a rare neoplasm that originates from follicular dendritic cells in lymphoid follicles. This disease usually involves the lymph nodes, and especially the head and neck area. Rarely, extranodal sites may be affected, including tonsil, the oral cavity, liver, spleen and the gastrointestinal tract. We report here on the imaging findings of follicular dendritic cell sarcoma of the abdomen that involved the retroperitoneal lymph nodes and colon. It shows as a well-defined, enhancing homogenous mass with internal necrosis and regional lymphadenopathy.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Abdomen/diagnostic imaging , Abdominal Neoplasms/complications , Abdominal Pain/etiology , Colon/diagnostic imaging , Colonic Neoplasms/complications , Dendritic Cell Sarcoma, Follicular/complications , Dendritic Cells, Follicular/diagnostic imaging , Diagnosis, Differential , Dyspepsia/etiology , Gastrointestinal Hemorrhage/etiology , Lymph Nodes , Radiography, Abdominal/methods , Retroperitoneal Space/diagnostic imaging , Tomography, X-Ray Computed/methodsABSTRACT
Follicular dendritic cell sarcomas (FDCSs) are very rare and usually originate in lymph nodes. We report an exceedingly rare case with localization in the dorsal mediastinum and, for the first time, provide positron emission tomography (PET) data for this tumor. This report describes the case of a 76-year-old man with a clinically aggressive tumor in the dorsal mediastinum. Computed tomography scan revealed displacement of soft tissue and lymph nodes. PET showed that the tumor had a high proliferation rate. Investigation of the successfully removed tumor mass revealed reactivity of the tumor cells for follicular dendritic cell markers and desmosomes linking adjacent tumor cells at the ultrastructural level. Marked atypia, a high mitotic rate, and areas of coagulative necrosis were found. The tumor in our case revealed the typical features and thus was classified as FDCS. In contrast to previous reports in the literature, preoperative imaging, histology, and immunohistochemistry studies indicated at least an intermediate degree of malignancy. Nevertheless, the patient made a good postoperative recovery and remained apparently disease-free 2 years later.
