ABSTRACT
BACKGROUND: An effective prophylactic treatment of patients with polymorphic light eruption (PLE) consists of repeated low, gradually increasing exposures to UVB radiation. This so-called UV(B) hardening induces better tolerance of the skin to sunlight. OBJECTIVE: SunshowerMedical company (Amsterdam) has developed an UV (B) source that can be used during taking shower. The low UV fluence of this apparatus makes it an interesting device for UV hardening. In a group of PLE patients, we compared the effectiveness of the irradiation with SunshowerMedical at home with that of the UVB treatment in the hospital. METHODS: The PLE patients were randomized for one of the treatments. The hospital treatment consisted of irradiations with broad-band UVB (Waldmann 85/UV21 lamps) twice a week during 6 weeks. The home UV-device was used each day with the maximal irradiation time of 6 min. The outcome assessment was based on the information obtained from patients' dermatological quality of life (DLQI) questionnaires, the ability of both phototherapies to reduce the provocation reaction and from the patients' evaluation of the long-term benefits of their phototherapies. RESULTS: Sixteen patients completed treatment with SunshowerMedical and thirteen completed treatment in hospital. Both types of phototherapy were effective. There was a highly significant improvement in DLQI with either treatment. In most cases, the hardening reduced or even completely suppressed clinical UV provocation of PLE. The patients using SunshowerMedical at home were, however, much more content with the treatment procedure than the patients visiting the dermatological units. CONCLUSIONS: Both treatments were equally effective in the induction of skin tolerance to sunlight in PLE patients. However, the home treatment was much better accepted than the treatment in the hospital.
Subject(s)
Dermatitis, Photoallergic/radiotherapy , Skin/radiation effects , Ultraviolet Therapy/instrumentation , Ultraviolet Therapy/methods , Adolescent , Adult , Aged , Confidence Intervals , Dermatitis, Photoallergic/diagnosis , Equipment Design , Equipment Safety , Female , Follow-Up Studies , Home Care Services/statistics & numerical data , Hospitalization/statistics & numerical data , Humans , Male , Middle Aged , Netherlands , Photosensitivity Disorders/diagnosis , Photosensitivity Disorders/radiotherapy , Radiation Dosage , Severity of Illness Index , Skin/pathology , Treatment Outcome , Young AdultSubject(s)
Dermatitis, Photoallergic/immunology , Dermatitis, Photoallergic/radiotherapy , Immune Tolerance/radiation effects , Immunosuppression Therapy/methods , Ultraviolet Rays/adverse effects , Humans , Immune Tolerance/physiology , Sunlight/adverse effects , Vitamin D/analogs & derivatives , Vitamin D/pharmacologyABSTRACT
Polymorphic light eruption (PLE) is a common skin disorder provoked by exposure to UVR. Its clinical symptoms resemble those of a contact allergic reaction. PLE is generally considered a T-cell-mediated autoimmune reaction toward a yet unidentified antigen formed in UVR-exposed skin. Predisposition to such an immune reaction may result from aberrant epitope formation, increased immune reactivity to a universal epitope, or diminished propensity to UVR-induced immunosuppression or to the induction of tolerance. In a study comprising a total of 24 PLE patients and 24 healthy sex- and age-matched controls, we found that both groups demonstrated similar immunosuppression of contact sensitization to diphenylcyclopropenone by earlier exposure to solar-simulating UVR. However, only 1 out of 13 PLE patients (8%) versus 6 out of 11 controls (55%) that had been immunosuppressed by UVR exhibited a state of immunotolerance toward the same allergen after 10-24 months (P=0.023). We conclude that the impaired propensity to UVR-induced allergen-specific immunotolerance may promote recurrent PLE.
