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2.
Adv Skin Wound Care ; 36(7): 355-360, 2023 Jul 01.
Article in English | MEDLINE | ID: mdl-37212588

ABSTRACT

OBJECTIVE: Printed materials have been used as educational resources to assist healthcare professionals in evidence-based clinical practice by providing guidelines for treatment, prevention, and self-care. The aim of this study was to develop and validate a booklet on the risk assessment, prevention, and treatment of incontinence-associated dermatitis. METHODS: This was a descriptive, analytic, and quantitative study. The booklet was developed in six steps: situational diagnosis, development of the research question, integrative review of the literature, synthesis of knowledge, structuring and design, and validation of the content. An expert panel composed of 27 experienced nurses carried out content validation using the Delphi technique. The content validity index (CVI) and Cronbach α coefficient were calculated. RESULTS: The mean Cronbach α for the evaluation questionnaire was .91, indicating excellent internal consistency. The evaluators classified the content of the booklet from "inadequate" to "totally adequate" (overall CVI, 0.91) in the first round of consultation and from "adequate" and "totally adequate" (overall CVI, 1.0) in a second round of consultation. The booklet was therefore considered validated. CONCLUSIONS: A booklet on risk assessment, prevention, and treatment of incontinence-associated dermatitis was created and validated by an expert panel, obtaining 100% consensus among the evaluators in the second round of consultation.


Subject(s)
Dermatitis , Urinary Incontinence , Humans , Pamphlets , Self Care , Surveys and Questionnaires , Urinary Incontinence/complications , Urinary Incontinence/therapy , Dermatitis/diagnosis , Dermatitis/etiology , Dermatitis/prevention & control , Reproducibility of Results
4.
Pesqui. vet. bras ; 43: e07196, 2023. tab, ilus
Article in English | VETINDEX | ID: biblio-1448812

ABSTRACT

Allergic dogs are commonly sensitized to food allergens. We evaluated the use of the prick test to diagnose food allergies in dogs with pruritus and the efficacy of an exclusion diet based on the test. The prick test was performed in 10 healthy dogs and 34 dogs with pruritus, of which 25 received an exclusion diet for 60 days and was challenged with positive food on the test. pVAS and CADESI-4 were assessed on days 0, 30, and 60 after re-exposure. As a result, two control group dogs reacted to a single food allergen, milk and wheat. Of the 25 dogs with pruritus that reacted to food allergens, 24 (96%) reacted to more than one food allergen, and only one (4%) reacted to a single food protein: pork. In the test group (n=25), there was a significant improvement of pVAS and CADESI-4 after 30 and 60 days of dietary exclusion, with significant worsening of the scores with food allergen challenge. In conclusion, the prick test can be used for screening food allergens to make an exclusion diet.


Cães alérgicos são comumente sensibilizados a alérgenos alimentares. Nós avaliamos o uso do teste de puntura para o diagnóstico de alergias alimentares em cães com prurido e a eficácia de uma dieta de exclusão baseada no teste. O teste de puntura foi realizado em 10 cães saudáveis e em 34 cães com prurido, dos quais 25 receberam uma dieta de exclusão por 60 dias e depois desafiados com o alimento que foi positivo no teste. pVAS e CADESI-4 foram realizados nos dias 0, 30, 60 e depois da reexposição. Como resultados, dois cães do grupo controle reagiram a um único alérgeno alimentar, leite e trigo. Dos 25 cães com prurido que reagiram aos alérgenos alimentares, 24 (96%) reagiram a mais de um alérgeno alimentar e apenas um (4%) reagiu a uma única proteína, que foi porco. No grupo teste (n=25), houve uma significativa melhora do pVAS e CADESI-4 depois de 30 e 60 dias de dieta de exclusão, com significante piora dos scores com o desafio alimentar. Como conclusão, o teste de puntura pode ser usado para selecionar alérgenos alimentares para fazer uma dieta de exclusão.


Subject(s)
Animals , Dogs , Skin Tests/veterinary , Allergens/adverse effects , Diet/veterinary , Dog Diseases , Food Hypersensitivity/diagnosis , Food Hypersensitivity/veterinary , Pruritus/etiology , Triticum/adverse effects , Egg Hypersensitivity/diagnosis , Milk/adverse effects , Dermatitis/etiology , Dogs
5.
Acta Vet. Brasilica ; 17(2): 18-21, 2023. ilus
Article in English | VETINDEX | ID: biblio-1512863

ABSTRACT

Drug eruption, also known as cutaneous adverse drug reaction, is a rare disease that is difficult to diagnose, requiring a combination of history evaluation, physical assessment, and histopathological examination. Clinically, it presents with variable signs, from mild urticaria to epidermal necrosis. Treatment consists of discontinuing the causative or similar medication; lesion management; and, sometimes, implementing systemic immunosuppressive treatments. The prognosis is generally good, except when there is systemic involvement or extensive skin necrosis. This study aims to describe the lesions, diagnosis, and evolution of a young cat presenting with drug eruption following the use of multiple medications for the treatment of systemic conditions. The patient underwent skin biopsy after showing progression of alopecic and localized lesions, which resulted in a suggestive diagnosis of superficial pustular drug eruption. Previous drug treatments were interrupted, but due to the lack of improvement in the lesion pattern, we chose to re-administer chlorambucil at a dose of 2 mg/cat every 48 h for therapeutic purposes. Up to the present time, the patient has been undergoing treatment and lesion management, with healthy-looking scar tissue and almost complete resolution of the skin lesions


A farmacodermia ou reação medicamentosa adversa cutânea é uma doença rara e de difícil diagnóstico, que demanda associação de histórico, avaliação física e exame histopatológico. Clinicamente apresenta sinais variáveis, desde leve urticária até necrose epidérmica. O tratamento consiste em descontinuar o medicamento causador ou semelhantes, realizar manejo das feridas e, por vezes, instituir tratamentos sistêmicos imunossupressores. O prognóstico geralmente é bom, exceto quando houver envolvimento sistêmico ou extensa lesão cutânea necrótica. O objetivo deste trabalho é descrever as lesões, diagnóstico e evolução de um gato jovem apresentando farmacodermia após o uso de múltiplas medicações para tratamento de afecções sistêmicas. O paciente foi submetido a biópsia cutânea após apresentar progressão de lesões alopécicas e localizadas, que resultou no diagnóstico sugestivo de farmacodermia pustular superficial. Foram interrompidos os tratamentos medicamentosos prévios, porém não havendo melhora do padrão lesional, optou-se pela readministração de clorambucil na dose de 2 mg/gato a cada 48 horas com objetivo terapêutico. Até o presente momento, o paciente encontra-se sob tratamento e manejo de feridas, com tecido cicatricial de aspecto saudável e quase total resolução de lesões cutânea


Subject(s)
Animals , Cats , Chlorambucil/administration & dosage , Dermatitis/etiology , Dermatitis/veterinary , Drug-Related Side Effects and Adverse Reactions/veterinary
6.
Rev. Hosp. Clin. Univ. Chile ; 34(1): 32-39, 20230000. tab
Article in Spanish | LILACS | ID: biblio-1427140

ABSTRACT

The use of facemask has become a key element to prevent the infection of Covid-19. Its prolonged use, both, by health personnel and the general population, has caused the appearance of multiple adverse effects at the facial level; highlighting the report of symptoms such as discomfort with the mask, facial itching, redness, erythema, among others. The appearance of dermatological diseases such as acne, allergic and irritative contact dermatitis, and exacerbation of pre-existing pathologies such as acne, rosacea and seborrheic dermatitis are also frequent. Knowledge of these complications is important for their prevention and proper management. (AU)


Subject(s)
Humans , Male , Female , Facial Dermatoses/etiology , SARS-CoV-2 , Masks/adverse effects , Dermatitis/etiology
7.
Rev Gaucha Enferm ; 43: e20210326, 2022.
Article in English, Portuguese | MEDLINE | ID: mdl-36478009

ABSTRACT

OBJECTIVE: Verify the nursing knowledge about incontinence-associated dermatitis in a teaching hospital. METHOD: Descriptive, cross-sectional research with quantitative analysis carried out with 90 nurses from a university hospital in the northeast of the country between January and February 2021. Data were collected through a self-administered online questionnaire. Applied Fisher's exact association statistical test for crossing the variables. RESULTS: 75.6% of the participants had knowledge about the definition of incontinence-associated dermatitis, however most participants were wrong about several factors, such as: image identification (58.9%), evaluation (66.7%), prevention and treatment (58.9%), risk assessment method (62.2%). CONCLUSION: Participants have weaknesses in the knowledge of incontinence-associated dermatitis. It is recommended that this study should be reproduced in other scenarios, in order to contribute to the production of protocols to optimize the management of incontinence-associated dermatitis.


Subject(s)
Dermatitis , Hospitals, Teaching , Humans , Cross-Sectional Studies , Dermatitis/etiology
8.
Arq. ciências saúde UNIPAR ; 26(3): 367-378, set-dez. 2022.
Article in Portuguese | LILACS | ID: biblio-1399118

ABSTRACT

OBJETIVO: Este artigo analisou o perfil epidemiológico e clínico dos pacientes atendidos em um serviço terciário de Dermatologia no município de Ponta Grossa-PR no período de 2016 a 2018. MÉTODOS: Trata-se de um estudo descritivo, exploratório, transversal e de abordagem quantitativa com dados coletados do prontuário médico. RESULTADOS: A maioria dos pacientes atendidos (I) era do sexo feminino; (II) com mais de 50 anos; (III) realizaram somente uma consulta, (IV) não foram submetidos a exames adicionais; e (V) apresentavam comorbidades, sobretudo, dermatológicas; o segmento corporal com maior número de lesões dermatológicas foi a cabeça; o grupo diagnóstico mais comum foi a afecção dos anexos cutâneos e o diagnóstico mais frequente foi a ceratose actínica. CONCLUSÃO: O estudo é fundamental para demonstrar quais são os pacientes e as doenças dermatológicas comumente encaminhadas para o serviço especializado, o que pode direcionar ações de prevenção primária, secundária e terciária.


OBJECTIVE: This article analyzed the epidemiological and clinical profile of patients treated at the outpatient Dermatology clinic, during 2016-2018, located in the municipality of Ponta Grossa-PR. METHODS: This is a descriptive exploratory, cross-sectional study with a quantitative approach, with data collected from the medical records. RESULTS: Most of the patients examinated: (I) were female; (II) over 50 years old; (III) attended to a single consultation; (IV) were not submitted to additional exams; and (V) had comorbidities, especially dermatological; the head was the most affected body segment; the most common diagnostic group was cutaneous annexes affections and the most frequent diagnosis was actinic keratosis. CONCLUSION: The study is fundamental to demonstrate who are the patients and which are the dermatological diseases commonly referred to the specialized service, which can guide primary, secondary and tertiary prevention actions.


OBJETIVO: Este artículo analizó el perfil epidemiológico y clínico de los pacientes atendidos en un servicio terciario de Dermatología en el municipio de Ponta Grossa-PR en el período de 2016 a 2018. MÉTODOS: Se trata de un estudio descriptivo, exploratorio y transversal con un enfoque cuantitativo con datos recogidos de las historias clínicas. RESULTADOS: La mayoría de los pacientes atendidos (I) eran mujeres; (II) tenían más de 50 años; (III) tenían una sola consulta, (IV) no se sometieron a exámenes adicionales; y (V) presentaban comorbilidades, principalmente, dermatológicas; el segmento corporal con mayor número de lesiones dermatológicas fue la cabeza; el grupo diagnóstico más común fue la afección de apéndices cutáneos y el diagnóstico más frecuente fue la queratosis actínica. CONCLUSIÓN: El estudio es fundamental para demostrar cuáles son los pacientes y las enfermedades dermatológicas que se derivan habitualmente al servicio especializado, lo que puede dirigir las acciones de prevención primaria, secundaria y terciaria.


Subject(s)
Humans , Male , Female , Middle Aged , Health Profile , Epidemiology , Dermatology , Tertiary Prevention , Skin Diseases/etiology , Medical Records/statistics & numerical data , Cross-Sectional Studies/methods , Dermatitis/etiology , Eczema/etiology
9.
Radiat Oncol ; 17(1): 49, 2022 Mar 07.
Article in English | MEDLINE | ID: mdl-35255933

ABSTRACT

In-field dermatitis is a severe and common adverse effect of radiation therapy, that can cause significant pain and treatment interruptions in patients with squamous cell anal carcinoma (SCAC) being treated with radical chemoradiation protocols. There are no established therapies for the treatment of radiation induced dermatitis. Photobiomodulation (PBM) is an effective and low-cost treatment for radiation induced mucositis, but have recently been explored to treat in-field dermatitis. We present a case report of the successful use of PBM for the treatment of dermatitis in the anal area in a patient with SCAC treated with concomitant chemoradiation with curative intent and follow with a literature review of the recent advances and possibilities of the use of PBM as a promising strategy. PBM therapy proved to be efficient in the radiodermatitis treatment, both in relieving the symptoms and controlling dermatitis, in addition to improving the patient's quality of life.


Subject(s)
Anus Neoplasms/therapy , Carcinoma, Squamous Cell/therapy , Chemoradiotherapy/adverse effects , Dermatitis/etiology , Dermatitis/radiotherapy , Low-Level Light Therapy , Humans , Male , Middle Aged
10.
Bol Med Hosp Infant Mex ; 78(6): 652-656, 2021.
Article in Spanish | MEDLINE | ID: mdl-34934217

ABSTRACT

BACKGROUND: Palisaded neutrophilic granulomatous dermatitis is a rare cutaneous manifestation in children associated with autoimmune pathologies. The exact pathogenesis of this disease is still unknown. However, it has been suggested that the deposition of immune complexes could initiate this pathology. CASE REPORT: We describe the case of an 11-year-old female patient who presented with polymorphic lesions in extremities associated with polyarthralgia. She was diagnosed with systemic lupus erythematosus and lupus nephritis. Because of the skin lesions, histopathological and immunohistochemical skin studies (CD68, CD163, myeloperoxidase) were performed, which resulted in palisaded neutrophilic granulomatous dermatitis. Due to renal involvement, treatment was administered with methylprednisolone pulses, hydroxychloroquine, mycophenolate mofetil, antihypertensives, and nonsteroidal anti-inflammatory drugs. The clinical response was favorable during follow-up. CONCLUSIONS: Palisaded neutrophilic granulomatous dermatitis associated with systemic lupus erythematosus is unusual. Therefore, its recognition is important, as it may appear as the initial manifestation of this autoimmune disease.


INTRODUCCIÓN: La dermatitis granulomatosa neutrofílica en empalizada es una manifestación cutánea poco frecuente en la infancia que se asocia con patologías autoinmunitarias. La patogénesis exacta de esta enfermedad aún se desconoce. Sin embargo, se ha sugerido que el depósito de complejos inmunitarios podría iniciarla. CASO CLÍNICO: Se describe el caso de una paciente de 11 años que presentó lesiones polimórficas en las extremidades asociadas a poliartralgias. Fue diagnosticada de lupus eritematoso sistémico y nefritis lúpica. Por las lesiones en la piel, se realizaron estudios histopatológico e inmunohistoquímico (CD68, CD163, mieloperoxidasa), que dieron como resultado dermatitis granulomatosa neutrofílica en empalizada. Debido al compromiso renal, se administró tratamiento con pulsos de metilprednisolona, además de hidroxicloroquina, micofenolato de mofetilo, antihipertensivos y antiinflamatorios no esteroideos. La respuesta clínica fue favorable durante el seguimiento. CONCLUSIONES: La dermatitis granulomatosa neutrofílica en empalizada asociada a lupus eritematoso sistémico es inusual. Por ello, es importante su reconocimiento, ya que puede presentarse como manifestación inicial de la enfermedad autoinmunitaria.


Subject(s)
Dermatitis , Lupus Erythematosus, Systemic , Skin Diseases , Child , Dermatitis/diagnosis , Dermatitis/drug therapy , Dermatitis/etiology , Female , Granuloma/diagnosis , Granuloma/etiology , Humans , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/diagnosis , Lupus Erythematosus, Systemic/drug therapy
11.
Medicine (Baltimore) ; 100(42): e27155, 2021 Oct 22.
Article in English | MEDLINE | ID: mdl-34678859

ABSTRACT

ABSTRACT: The focus of this prospective cohort study was to evaluate the risk factors of severe acute skin toxicity (grade ≥2) in 100 patients with breast cancer (BC) during radiotherapy (RT).The patients were evaluated weekly during RT and 3 months after treatment. The endpoint included the occurrence of skin toxicity grade ≥2, according to Radiation Therapy Oncology Group (RTOG). Survival analysis was conducted by univariate and multivariate Cox regression analysis.In the multivariate analysis, RT in the afternoon (0-3 pm) (hazard ratios [HR] = 1.566, P = .042) was significantly associated with the early occurrence of skin toxicity, indicating a potential effect of chronotherapy related to this adverse event. In the univariate and multivariate analysis, skin phototype moderate brown (HR = 1.586, P = .042; HR = 1.706, P = .022, respectively) and dark brown or black (HR = 4.517, P < .001; HR = 5.336, P < 0.001, respectively) was significantly associated with the skin toxicity. Tangential field separation >21 cm (HR = 2.550, P = .009, HR = 2.923, P = .003), in women that were submitted to conservative surgery indicates indirectly that large breast size was also significantly associated with skin toxicity.Women with large breasts and dark brown or black skin should be followed more carefully during RT, which should be undergone in the morning, especially when submitted to conventional RT techniques, common in developing countries.


Subject(s)
Breast Neoplasms/radiotherapy , Dermatitis/etiology , Dermatitis/prevention & control , Radiation Injuries/prevention & control , Aged , Body Mass Index , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Female , Hospitals, University , Humans , Middle Aged , Prospective Studies , Radiation Dosage , Risk Factors , Skin/radiation effects , Socioeconomic Factors
12.
Vet Res Commun ; 45(4): 293-304, 2021 Dec.
Article in English | MEDLINE | ID: mdl-34219191

ABSTRACT

Wounds are damaging to quality life of confined animals, causing dysfunction in spinal, members injuries, and reduction in productive performance. This research investigated the clove antimicrobial and antioxidant activity on the healing of decubitus wounds (pododermatitis) of rabbits (Oryctolagus cuniculus). Adult animals were treated for 21 days every three days with a fluid gel spray in the wound region: control fluid gel without addition of clove (FGC0), fluid gel with addition of 1% clove powder (FGC1), and fluid gel with 2% clove powder (FGC2). Microbiological analysis for Escherichia coli and Pseudomonas spp. were performed during 21 days of experimental period. After this period, samples from treated skin were evaluated for histological analysis and evaluation of the healing process by spectroscopy (FTIR-ATR). Rabbits treated with FGC2 showed advanced healing and decreased tissue inflammation similar to healthy rabbits, while FGC0 rabbits showed a decrease in bacterial contamination without signs of healing. Both FGC1 and FGC2 rabbits demonstrated antimicrobial and antioxidant action against both bacteria tested, favoring the wound healing process. Considering the results, the use of fluid gel with 2% of clove powder (Syzigium aromaticum) based on the best antimicrobial, antioxidant and anti-inflammatory activities on healing of decubitus wounds (pododermatitis) of rabbits in commercial farming system.


Subject(s)
Anti-Bacterial Agents/pharmacology , Antioxidants/pharmacology , Foot Diseases/veterinary , Gels/therapeutic use , Pressure Ulcer/veterinary , Rabbits , Syzygium/chemistry , Animals , Dermatitis/etiology , Dermatitis/prevention & control , Dermatitis/veterinary , Female , Foot Diseases/etiology , Foot Diseases/prevention & control , Male , Plant Extracts/chemistry , Plant Extracts/pharmacology , Pressure Ulcer/etiology , Pressure Ulcer/prevention & control , Rabbits/injuries , Wound Healing
13.
Am J Dermatopathol ; 43(8): 543-553, 2021 Aug 01.
Article in English | MEDLINE | ID: mdl-34276026

ABSTRACT

IMPORTANCE: Reactions to tattoo may simulate common dermatosis or skin neoplasms. Histopathology allows diagnosis and helps determining the level and degree of inflammation associated, consequently orientating treatment. OBJECTIVE: To describe the histological features found in biopsies of cutaneous reactions to tattoo. DESIGN: This study was designed as a multicenter case series. SETTING: All consecutive histopathological samples of tattoos referred from 1992 to 2019 to the Hospital General de Catalunya, Hospital Germans Trias i Pujol, and a private practice, all in Barcelona, Spain, and from the Kempf und Pfaltz Histologische Diagnostik in Zurich, Switzerland were retrieved from the files. PARTICIPANTS AND EXPOSURE: The inclusion criteria were all cosmetic/permanent makeup, artistic/professional, and traumatic tattoos associated with either inflammatory reactions alone and/or with tumors and/or infections. Exclusion criteria were cases without any associated pathologic finding in the place of the ink, amalgam tattoos, and medical or temporary tattoos. MAIN OUTCOMES AND MEASURES: In all patients, clinical features (age, sex, location, tattoo color, and presentation) were recorded. Histological features evaluated included ink color, associated tumors or infections, and inflammatory reaction pattern. Inflammation was graded in low to moderate or severe. RESULTS: From 477 biopsies diagnosed as tattoos, 230 cases from 226 patients met the inclusion criteria. Samples corresponded to 107 male and 120 female subjects and 3 of unknown gender. Median age was 39 years (ranging from 9 to 84 years). Fifty-three samples were referred from centers in Spain and 177 from the center in Switzerland. The series was analyzed in 2 parts: tattoos associated only with inflammatory reactions (117/230) and tattoos associated with tumors or infections (113/230). The most common form of inflammatory pattern associated with tattoo was the fibrosing reaction (79/117, 68%), followed by granulomatous reaction (56/117, 48%), lichenoid reaction (33/117, 28%), epithelial hyperplasia (28/117, 24%), pseudolymphoma (27/117, 23%) and spongiotic reaction (27/117, 23%). Combined features of 2 or more types of inflammatory patterns were seen in 64% cases. CONCLUSIONS AND RELEVANCE: Our series confirms that cutaneous reactions to tattoos are polymorphous. Inflammation tends to present with combined patterns. Infections are tending to decline, and pathologic findings are not specific to ink color or clinical features.


Subject(s)
Dermatitis/pathology , Skin Diseases, Infectious/pathology , Skin Neoplasms/pathology , Skin/pathology , Tattooing/adverse effects , Adolescent , Adult , Aged , Aged, 80 and over , Biopsy , Child , Color , Coloring Agents/adverse effects , Dermatitis/etiology , Female , Granuloma/etiology , Granuloma/pathology , Humans , Ink , Lichenoid Eruptions/etiology , Lichenoid Eruptions/pathology , Male , Middle Aged , Pseudolymphoma/etiology , Pseudolymphoma/pathology , Skin Diseases, Infectious/etiology , Young Adult
16.
Clin Transl Oncol ; 23(3): 543-553, 2021 Mar.
Article in English | MEDLINE | ID: mdl-32671728

ABSTRACT

PURPOSE: Radiochemotherapy (RCT) is an effective standard therapy for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Nonetheless, toxicity is common, with patients often requiring dose modifications. METHODS: To investigate associations of RCT toxicities according to CTCAE version 5.0 and subsequent therapy modifications with short- and long-term treatment outcomes, we studied all 193 patients with HNSCC who received RCT (70 Gy + platinum agent) at an academic center between 03/2010 and 04/2018. RESULTS: During RCT, 77 (41%, 95% CI 34-49) patients developed at least one ≥ grade 3 toxicity, including seven grade 4 and 3 fatal grade 5 toxicities. The most frequent any-grade toxicities were xerostomia (n = 187), stomatitis (n = 181), dermatitis (n = 174), and leucopenia (n = 98). Eleven patients (6%) had their radiotherapy schedule modified (mean radiotherapy dose reduction = 12 Gy), and 120 patients (64%) had chemotherapy modifications (permanent discontinuation: n = 67, pause: n = 34, dose reduction: n = 7, change to other chemotherapy: n = 10). Objective response rates to RCT were 55% and 88% in patients with and without radiotherapy modifications (p = 0.003), and 84% and 88% in patients with and without chemotherapy modifications (p = 0.468), respectively. Five-year progression-free survival estimates were 20% and 50% in patients with and without radiotherapy modifications (p = < 0.001), and 53% and 40% in patients with and without chemotherapy modifications (p = 0.88), respectively. CONCLUSIONS: Reductions of radiotherapy dose were associated with impaired long-term outcomes, whereas reductions in chemotherapy intensity were not. This suggests that toxicities during RCT should be primarily managed by modifying chemotherapy rather than radiotherapy.


Subject(s)
Chemoradiotherapy/adverse effects , Head and Neck Neoplasms/therapy , Squamous Cell Carcinoma of Head and Neck/therapy , Aged , Carboplatin/adverse effects , Carboplatin/therapeutic use , Chemoradiotherapy/methods , Cisplatin/adverse effects , Cisplatin/therapeutic use , Dermatitis/etiology , Female , Head and Neck Neoplasms/mortality , Head and Neck Neoplasms/pathology , Humans , Induction Chemotherapy/adverse effects , Induction Chemotherapy/statistics & numerical data , Leukopenia/etiology , Middle Aged , Progression-Free Survival , Radiation-Sensitizing Agents/adverse effects , Radiation-Sensitizing Agents/therapeutic use , Radiotherapy Dosage , Radiotherapy, Intensity-Modulated/adverse effects , Radiotherapy, Intensity-Modulated/methods , Retrospective Studies , Squamous Cell Carcinoma of Head and Neck/mortality , Squamous Cell Carcinoma of Head and Neck/pathology , Stomatitis, Aphthous/etiology , Treatment Outcome , Xerostomia/etiology
17.
Clin Transl Oncol ; 23(2): 372-377, 2021 Feb.
Article in English | MEDLINE | ID: mdl-32617869

ABSTRACT

PURPOSE: Weekly irradiation in breast cancer in elderly patients is a treatment option, whose tolerance may be influenced by the fractionation used. The objective of this study is to compare the tolerance and long-term side effects of two different fractionations. MATERIALS AND METHODS: 47 elderly patients were recruited after conservative or radical treatment that also received irradiation with a dose per fraction of 6.25 Gy or 5 Gy for one session per week, 6 sessions in total. The long-term tolerance results are compared by assessing toxicity using CTCAE version 5.0 scales for dermatitis, telangectasia, fibrosis and pain of the irradiated breast. In addition, objective parameters of skin status (erythema, hyperpigmentation, elasticity and hydration) by a multi-probe MultiSkin Test-Center system were obtained and compared between groups. RESULTS: After an average follow-up of 5 years, all patients were free of disease and with complete local control. A total of 20 patients with 6.25 Gy fractionation and 27 patients with 5 Gy fractionation have been included. Patients treated with lower fractionation had a lower incidence of dermatitis, telangectasia, fibrosis, or local pain. The decrease in elasticity measured by the multi-probe system was smaller with the fractionation of 5 Gy. No differences were observed in the other objective parameters. CONCLUSION: Weekly irradiation with 5 Gy fractionation is better tolerated than with higher fractionation.


Subject(s)
Breast Neoplasms/radiotherapy , Radiation Dose Hypofractionation , Aged , Aged, 80 and over , Breast Neoplasms/surgery , Dermatitis/epidemiology , Dermatitis/etiology , Female , Fibrosis/epidemiology , Fibrosis/etiology , Humans , Margins of Excision , Pain/epidemiology , Pain/etiology , Radiation Injuries/epidemiology , Radiation Tolerance , Radiotherapy Dosage , Telangiectasis/epidemiology , Telangiectasis/etiology , Time Factors
19.
Rev Bras Enferm ; 73Suppl 3(Suppl 3): e20190374, 2020.
Article in English, Portuguese | MEDLINE | ID: mdl-32965435

ABSTRACT

OBJECTIVE: To identify the frequency and factors associated to incontinence associated dermatitis in elderly people. METHODS: Cross-sectional study with 202 elderly patients admitted to a university hospital between September 2017 and January 2018. Data collection included: cognitive screening, sociodemographic and clinical questionnaire. It was performed exploratory and descriptive analysis, where prevalence and ratios (PR) were calculated. RESULTS: Prevalence of injury was 9.4%, age range 70-79 years (13.5%), African American (21.4%), hospitalization period ≥ 21 days (44.4%), in use of nasogastric tube (33.3%), medical device (11.3%), restricted mobility (18.5%). It was associated with hospitalization period, use of nasogastric tube, restricted mobility, medical devices, and cognition. CONCLUSION: It was confirmed an average frequency of incontinence associated dermatitis in elderly patients and association to factors such as hospitalization period, immobility, cognition, use of nasogastric tube and devices. It must be highlighted the importance of prevention measures, early detection, assessment and monitoring of this type of injury.


Subject(s)
Dermatitis , Fecal Incontinence , Urinary Incontinence , Aged , Cross-Sectional Studies , Dermatitis/epidemiology , Dermatitis/etiology , Fecal Incontinence/complications , Fecal Incontinence/epidemiology , Hospitalization , Hospitals, University , Humans , Prevalence , Urinary Incontinence/complications , Urinary Incontinence/epidemiology
20.
Pesqui. vet. bras ; 40(8): 579-588, Aug. 2020. tab, ilus
Article in English | VETINDEX | ID: vti-32457

ABSTRACT

Skin diseases in pigs can negatively impact the production. They cause losses related to the death of the affected pigs, to the cost with the treatment, growth retardation and condemnations in the slaughterhouses. This study was developed to determine the frequency and describe the histopathological findings of skin diseases in pigs in different age groups through a retrospective study from 2006 to 2018. A total of 154 conclusive cases were analyzed, including skin restricted diseases (allergic dermatitis, exudative epidermitis, vesicular dermatitis, pityriasis rosea, swinepox, follicular cyst, papilloma and scrotal hemangioma) or skin lesions secondary to systemic diseases (erysipelas, porcine dermatitis and nephropathy syndrome (PDNS), bacterial septicemia and multiple hemorrhages without definite cause). The skin lesions were classified as bacterial (46.1%), viral (26.6%), allergic (12.3%), neoplastic (1.3%) and others (13.6%). Swine erysipelas was the most frequent diagnosis (47/154), followed by PDNS (23/154), allergic dermatitis (19/154) and exudative epidermitis (15/154). Vesicular dermatitis (9/154), pityriasis rosea (9/154), septicemia with cutaneous manifestations (9/154), swinepox (9/154) and multiple hemorrhages without definite cause (7/154) were also observed. Follicular cyst (3/154), hyperkeratosis without definite cause (2/154), papilloma (1/154), and scrotal hemangioma (1/154) were less frequently described. Of the conclusive diagnosis, age was reported in 138 cases, with the highest frequency of skin lesions observed at the inspection process during slaughter (56/138).(AU)


As doenças de pele em suínos podem impactar negativamente a produção. Estas causam perdas relacionadas à morte dos acometidos, a custo com tratamentos, atraso no crescimento e condenações nos frigoríficos. Este trabalho foi desenvolvido para determinar a frequência e descrever os achados histopatológicos das doenças de pele em suínos nas diferentes faixas etárias, através de um estudo retrospectivo no período de 2006 a 2018. Foram analisados 154 casos conclusivos incluindo as doenças restritas a pele (dermatites alérgicas, epidermite exsudativa, dermatite vesicular, pitiríase rósea, varíola suína, cisto folicular, papiloma e hemangioma escrotal) e as secundárias a doenças sistêmicas (erisipela, síndrome dermatite nefropatia suína (SDNS), septicemia bacteriana e hemorragias múltiplas de causa não determinada). Estas foram classificadas em bacterianas (46,1%), virais (26,6%), alérgicas (12,3%), neoplásicas (1,3%) e outras (13,6%). A erisipela suína foi a enfermidade mais diagnosticada (47/154), seguida por SDNS (23/154), dermatite alérgica (19/154) e epidermite exsudativa (15/154). Observamos ainda dermatite vesicular (9/154), pitiríase rósea (9/154), septicemia bacteriana com manifestações cutâneas (9/154), varíola suína (9/154) e hemorragias múltiplas de causa não determinada (7/154). Em menor número, cisto folicular (3/154), hiperqueratose sem causa definida (2/154), papiloma (1/154) e hemangioma escrotal (1/154). Dos casos conclusivos, a idade foi informada em 138 casos, sendo a maior frequência das lesões de pele observadas na linha de inspeção, durante o abate (56/138).(AU)


Subject(s)
Animals , Skin Diseases, Viral/pathology , Skin Diseases, Viral/epidemiology , Skin Diseases, Bacterial/pathology , Skin Diseases, Bacterial/epidemiology , Sus scrofa/injuries , Dermatitis/etiology , Dermatitis/pathology , Dermatitis/epidemiology , Skin/injuries , Swine Diseases , Abattoirs
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