ABSTRACT
Os autores realizaram uma revisão da literatura sobre dermatite herpetiforme (DH), apresentando os acometimentos cutâneos e bucais. Tal enfermidade, de provável etiologia auto-imune, consiste de uma doença crônica vesicobolhosa caracterizada clinicamente por pápulas e vesículas pruriginosas. Microscopicamente, através de fluorescência, pode ser observada a presença de depósito granular de IgA ao longo de membrana basal. Há associação entre pacientes portadores de DH e a sensibilidade ao glúten, esse achado também encontrado na doença celíaca. O tratamento recomendado para essa enfermidade é medicamentoso associado a uma dieta livre de glúten. Neste artigo discorre-se sobre etiologia, relações com enteropatia, influência do glúten, tratamento e diagnósticos diferenciais.
Subject(s)
Male , Female , Dermatitis Herpetiformis/diagnosis , Dermatitis Herpetiformis/physiopathology , Dermatitis Herpetiformis/therapy , Celiac Disease/complications , Chronic Disease , Glutens/adverse effectsSubject(s)
Humans , Dermatitis Herpetiformis/diagnosis , Celiac Disease/complications , Dermatitis Herpetiformis/complications , Dermatitis Herpetiformis/physiopathology , Prognosis , Cimetidine/therapeutic use , Vitamin E/therapeutic use , Dapsone/adverse effects , Dapsone/therapeutic use , Diagnosis, Differential , Glutens/adverse effects , Celiac Disease/diet therapy , Self-Evaluation ProgramsSubject(s)
Humans , Dermatitis Herpetiformis/diagnosis , Celiac Disease/complications , Cimetidine/therapeutic use , Dapsone/adverse effects , Dapsone/therapeutic use , Dermatitis Herpetiformis/complications , Dermatitis Herpetiformis/physiopathology , Diagnosis, Differential , Celiac Disease/diet therapy , Glutens/adverse effects , Prognosis , Self-Evaluation Programs , Vitamin E/therapeutic useABSTRACT
A dermatite herpetiforme é uma doença bolhosa crônica, sensível ao glúten, relacionada a us risco aumentado para o desenvolvimento de linfoma. Através deste artigo, foi realizada uma revisão bibliográfica sobre seus aspectos epidemiológicos clínicos e terapêuticos.
Dermatitis herpetiformis is a lifelong, gluten sensitive skin disease, that is associated with an increased risk for lymphoma. It was made a bibliographic review about its epidemiological, clinical and therapeutical features.
Subject(s)
Humans , Male , Female , Dermatitis Herpetiformis/etiology , Dermatitis Herpetiformis/physiopathology , Dermatitis Herpetiformis/therapy , Diagnosis, Differential , Skin Diseases, VesiculobullousABSTRACT
A dermatite herpetiforme ou dermatite de Duhring-Brocq e uma dermatose bolhosa caracterizada por lesoes polimorficas compostas de papulas, vesiculas, bolhas e crostas intensamente pruriginosas. Histologicamente, uma bolha subepidermica e formada, principalmente com infiltrado neutrofilico, fibrina e edema. Essa dermatose pode ser uma manifestacao paraneoplasica de diversos tumores malignos, mas raramente relaciona-se a neoplasias de cervice uterina. Os autores apresentam um caso de dermatite herpetiforme como dermatose paraneoplasica de carcinoma de colo de utero
Subject(s)
Humans , Female , Adult , Dermatitis Herpetiformis/diagnosis , Dermatitis Herpetiformis/physiopathology , Paraneoplastic Syndromes , Skin Diseases, Vesiculobullous/diagnosisSubject(s)
Dermatitis Herpetiformis , Intestinal Mucosa/pathology , Biopsy , Child , Child, Preschool , Contrast Media , Dermatitis Herpetiformis/enzymology , Dermatitis Herpetiformis/pathology , Dermatitis Herpetiformis/physiopathology , Female , Glycoside Hydrolases/metabolism , Humans , Intestinal Mucosa/enzymology , Iodine/adverse effects , Jamaica , Jejunum/pathology , Lactose Intolerance/etiology , Male , Microscopy, Electron , Nutrition Disorders/complications , Recurrence/etiology , Sucrase/metabolism , Water SupplyABSTRACT
Malabsorption and jejunal abnormalities have been described in some adult patients with dermatitis herpetiformis, but no studies have been made in children. Six children under the age of eleven years with dermatitis heptiformis have been investigated. Serum levels of proteins, folic acid, iron, calcium and phospated were measured. Barium meals, xylose tolerance tests and faecal fat measurements were also done. Peroral jejunal biopsies were performed and examined for disaccharidase levels and histological changes. In all children the haemoglobin was above 10 grams percent: two had eosinophilia: in one case associated with ascaris lumbricoides infestation. Serum levels of calcium, phosphate, and folate were all normal as were faecal fat excretion rates. Three children had abnormal xylose tolerance tests and one a low serum iron while in two children the barium meals were suggestive of malabsorption. All the jejunal biopsies showed villous abnormalities on histological examination, but with the exception of lactase, which in three cases was less than 1 unit per gram of wet weight of mucosa, the disaccharidase levels were normal. It is concluded that these children have jejunal abnormalities often associated with lactase deficiency(AU)
Subject(s)
Child , Humans , Dermatitis Herpetiformis/physiopathology , Jejunum/physiopathology , Malabsorption SyndromesABSTRACT
Il caso attuale, che formò l'oggeto di una mia brevissima comunicazione preventiva, alla Riunione della Società Italiana di Dermatologia e Sifilografia tenuta in Roma nel Dicembre 1908 (1), merita, a mio avviso, di essere ampiamente studiato, e per la singolarità della forma clinica in sè, e per alcune particolarità, in rapporto al probabile processo patogenetico e alle lesioni istologiche della cute, che l'esame consecutivo della inferma ha permesso di mettere in rilievo.