ABSTRACT
It has been demonstrated that intrauterine growth retardation, defined as birth weight below the 10th percentile, gives rise to a reduction in nephron number. Oligonephropathy has been suggested to increase the risk for systemic and glomerular hypertension in adult life as well as enhance risk for expression of renal disease after exposure to potentially injurious renal stimuli. Diseases, such as diabetes, that damage the kidney, may enhance this risk. In addition, it has been hypothesized that the same factors affecting kidneys in utero also impact on pancreatic tissue development, thus predisposing infants of low birth weight to an increased risk for the subsequent development of diabetes and diabetic nephropathy, consistent with the so-called "thrifty phenotype" hypothesis. Impact of low birth weight on nondiabetic renal disease has also been shown in some studies. In the current scenario, chronic kidney disease is increasing all over the world and the major two causes are diabetes and hypertension. Once the issues are shifting from management of end-stage renal disease to prevention of chronic kidney disease, prevention of low birth weight is likely to be an issue for the nephrologists in future.
Subject(s)
Fetal Growth Retardation/epidemiology , Infant, Low Birth Weight , Kidney Diseases/congenital , Kidney Diseases/epidemiology , Child Development/physiology , Comorbidity , Diabetic Nephropathies/congenital , Diabetic Nephropathies/diagnosis , Diabetic Nephropathies/epidemiology , Female , Fetal Growth Retardation/diagnosis , Follow-Up Studies , Humans , Hypertension, Renal/congenital , Hypertension, Renal/diagnosis , Hypertension, Renal/epidemiology , Incidence , India , Infant, Newborn , Kidney Diseases/diagnosis , Kidney Function Tests , Male , Nephrons/embryology , Organogenesis/physiology , Pregnancy , Risk FactorsABSTRACT
We studied the effect of pyridoxal-5'-phosphate (PAL-P) on protein glycosylation and diabetic nephropathy in NSY mice. In experiment 1, an in vitro model of the browning phenomenon involving the incubation of lysine and glucose was inhibited by PAL-P. In experiment 2, administration of PAL-P to congenitally diabetic NSY mice markedly reduced the thickening of the glomerular basement membrane. These results suggest that PAL-P has the potential to be used for reducing the nephrotic complications of diabetes mellitus.