1.
PLoS One
; 11(10): e0164577, 2016.
Article
in English
| MEDLINE
| ID: mdl-27727306
ABSTRACT
The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and 25°C/60%RH in bottles and oral syringes for a total of 90 days. At predetermined time intervals, suspensions were inspected for homogeneity, color or odor change; the pH was measured and the concentration of diazoxide was evaluated by ultraviolet detection using a stability-indicating high pressure liquid chromatography method. All preparations were demonstrated to be chemically stable for at least 90 days.
Subject(s)
Diazoxide/chemistry , Capsules/chemistry , Chromatography, High Pressure Liquid , Diazoxide/analysis , Drug Compounding , Drug Stability , Drug Storage , Hydrogen-Ion Concentration , Spectrophotometry, Ultraviolet , Temperature
2.
Drug Metab Dispos
; 3(3): 226-9, 1975.
Article
in English
| MEDLINE
| ID: mdl-238822
Subject(s)
Diazoxide/metabolism , Adult , Animals , Child , Diazoxide/analysis , Dogs , Guinea Pigs , Half-Life , Haplorhini , Humans , Kidney/metabolism , Protein Binding , Rabbits , Rats , Species Specificity , Structure-Activity Relationship
3.
Diabetes
; 20(7): 457-66, 1971 Jul.
Article
in English
| MEDLINE
| ID: mdl-4397560
Subject(s)
Adenine Nucleotides/pharmacology , Diazoxide/pharmacology , Glucagon/pharmacology , Glucose/pharmacology , Imidazoles/pharmacology , Insulin/metabolism , Pancreas/metabolism , Phenoxybenzamine/pharmacology , Theophylline/pharmacology , Adrenergic alpha-Antagonists/pharmacology , Animals , Buffers , Cyclic AMP/analysis , Cyclic AMP/antagonists & inhibitors , Cyclic AMP/pharmacology , Diazoxide/analysis , Diazoxide/antagonists & inhibitors , Glucagon/analysis , Glucagon/antagonists & inhibitors , Glucose/analysis , Glucose/antagonists & inhibitors , Imidazoles/analysis , Imidazoles/antagonists & inhibitors , Insulin Secretion , Male , Pancreas/drug effects , Perfusion , Phenoxybenzamine/analysis , Phenoxybenzamine/antagonists & inhibitors , Radioimmunoassay , Rats , Stimulation, Chemical , Theophylline/analysis , Theophylline/antagonists & inhibitors
4.
Diabetes
; 20(7): 449-56, 1971 Jul.
Article
in English
| MEDLINE
| ID: mdl-5556282
