Subject(s)
Atropine/pharmacology , Pupil/drug effects , Atropine/adverse effects , Dilatation/drug effects , HumansSubject(s)
Heroin Dependence/physiopathology , Pupil/physiopathology , Substance Withdrawal Syndrome/physiopathology , Adult , Circadian Rhythm , Constriction , Dilatation/drug effects , Heroin/administration & dosage , Heroin/pharmacology , Humans , Male , Pupil/drug effects , Reflex, Pupillary/drug effects , United States , VietnamSubject(s)
Ethanol , Physical Exertion , Dilatation/drug effects , Ethanol/administration & dosage , Ethanol/adverse effects , Ethanol/metabolism , Ethanol/pharmacology , Glucose/therapeutic use , Humans , Hypoglycemia/chemically induced , Hypoglycemia/drug therapy , Liver Glycogen/antagonists & inhibitors , Shivering/drug effects , Vasomotor System/drug effectsSubject(s)
Acetylcholine/pharmacology , Kidney/blood supply , Regional Blood Flow/drug effects , Acetylcholine/administration & dosage , Acetylcholine/antagonists & inhibitors , Adult , Angiography , Atropine/pharmacology , Blood Flow Velocity , Catheterization , Dilatation/drug effects , Hemodynamics , Humans , Kidney/drug effects , Middle Aged , Renal Artery , Renal Veins , Vasodilator Agents/pharmacology , XenonSubject(s)
Hemodynamics/drug effects , Vasodilator Agents/pharmacology , Xanthines/pharmacology , Animals , Blood Circulation/drug effects , Blood Pressure/drug effects , Blood Vessels/drug effects , Brain Chemistry , Cats , Coronary Vessels/drug effects , Dilatation/drug effects , Diuresis/drug effects , Ear/drug effects , Guinea Pigs , Heart/drug effects , Heart Rate/drug effects , Mice , Oxygen/analysis , Oxygen/blood , Phosphoric Monoester Hydrolases/antagonists & inhibitors , Rabbits , Rats , Regional Blood Flow/drug effects , Vascular Resistance/drug effectsSubject(s)
Prostaglandins/therapeutic use , Animals , Blood Circulation/drug effects , Blood Platelets/drug effects , Blood Vessels/drug effects , Bronchi/drug effects , Bronchodilator Agents/therapeutic use , Carbohydrate Metabolism , Cats , Central Nervous System/drug effects , Chemical Phenomena , Chemistry , Coronary Disease/drug therapy , Diet Therapy , Digestive System/drug effects , Dilatation/drug effects , Dogs , Female , Fertility/drug effects , Heart/drug effects , Humans , In Vitro Techniques , Linoleic Acids/pharmacology , Lipid Metabolism , Muscles/drug effects , Oxytocics/therapeutic use , Platelet Adhesiveness/drug effects , Prostaglandins/analysis , Prostaglandins/biosynthesis , Prostaglandins/isolation & purification , Prostaglandins/metabolism , Prostaglandins/pharmacology , Prostaglandins/physiology , Rats , Uterus/drug effectsSubject(s)
Black People , Mydriatics/pharmacology , Adolescent , Adult , Aged , Child , Dilatation/drug effects , Female , Humans , Iris/anatomy & histology , Male , Middle Aged , Pupil/drug effects , UgandaSubject(s)
Epinephrine/pharmacology , Ganglionic Blockers , Norepinephrine/pharmacology , Reflex/drug effects , Anesthesia, Spinal , Animals , Bis-Trimethylammonium Compounds/pharmacology , Dilatation/drug effects , Dogs , Electric Stimulation , Epinephrine/administration & dosage , Female , Hindlimb/innervation , Injections, Intravenous , Male , Norepinephrine/administration & dosage , Perfusion , Quaternary Ammonium Compounds/pharmacology , SympathectomySubject(s)
Glycine/pharmacology , Hemodynamics/drug effects , Magnesium/pharmacology , Orotic Acid/pharmacology , Animals , Blood Circulation/drug effects , Coronary Vessels/drug effects , Coronary Vessels/physiology , Dilatation/drug effects , Dogs , Female , Femoral Artery/drug effects , Femoral Artery/physiology , Heart Rate/drug effects , Magnesium/administration & dosage , Male , Pulse/drug effects , Vascular Resistance/drug effectsSubject(s)
Blood Vessels/drug effects , Ear, External/blood supply , Isoproterenol/pharmacology , Animals , Arteries/drug effects , Barium/pharmacology , Chlorides/pharmacology , Constriction/drug effects , Dilatation/drug effects , Drug Synergism , Electric Stimulation , Ergotamine/pharmacology , In Vitro Techniques , Isoproterenol/antagonists & inhibitors , Perfusion , Propranolol/pharmacology , Rabbits , Receptors, Drug , Sympathetic Nervous System/drug effectsSubject(s)
Blood Flow Velocity , Animals , Blood Pressure , Capillaries/drug effects , Dilatation/drug effectsABSTRACT
1. The beta-adrenoceptor antagonist activity of 3-methoxyisoprenaline, the O-methylated metabolite of isoprenaline, was studied on isolated driven atrial strip and tracheal chain preparations of the guinea-pig and on the hind limb blood flow of the dog.2. On both the atrial strip and tracheal chain preparations the blockade of responses to isoprenaline fulfilled the criteria for simple competitive inhibition.3. 3-Methoxyisoprenaline decreased the vasodilator response to isoprenaline in the dog hind limb, but did not affect the response to noradrenaline.4. 3-Methoxyisoprenaline had about 1/3,700 of the potency of propranolol as a beta-adrenoceptor antagonist on the tracheal chain preparation, 1/1,000 on the atrial strip preparation and less than 1/400 on the hind limb blood flow.5. The antagonist activity of 3-methoxyisoprenaline showed a slight specificity for cardiac beta-adrenoceptors, being 4.3 times more active on guinea-pig atria than on trachea.6. Although 3-methoxyisoprenaline antagonized the actions of isoprenaline in the three preparations, its activity was extremely weak. It is unlikely that the formation of 3-methoxyisoprenaline from isoprenaline, administered therapeutically, could lead to beta-adrenoceptor blockade.
Subject(s)
Heart/drug effects , Muscle, Smooth/drug effects , Regional Blood Flow/drug effects , Sympatholytics/pharmacology , Adrenergic beta-Antagonists/pharmacology , Animals , Blood Vessels/drug effects , Dilatation/drug effects , Dogs , Female , Guinea Pigs , Hindlimb/blood supply , In Vitro Techniques , Isoproterenol/antagonists & inhibitors , Isoproterenol/metabolism , Isoproterenol/therapeutic use , Male , Muscle Contraction/drug effects , Norepinephrine/pharmacology , Propranolol/pharmacology , Trachea/drug effectsSubject(s)
Body Fluids , Animals , Blood Flow Velocity , Capillary Permeability , Cats , Dilatation/drug effectsABSTRACT
1. Earlier it had been found that during fat mobilization there was an increased blood flow in the adipose tissue and the tissue contained a vasodilator substance.2. Extract of an activated fat pad contained 3 to 25 times as much activity as the contralateral resting fat pad.3. The following findings suggest that the vasodilator substance is prostagladin E(2):(a) It caused contractions of the guinea-pig ileum which were not reduced by mepyramine, but were reduced by atropine.(b) It caused a prolonged vasodilator response when injected closearterially to the epigastric fat pad.(c) It was eluted from a silicic acid column by a solvent system which is known to elute prostaglandins of the E series but not those of the F series.(d) Its indices of discrimination were similar to those of prostaglandin E's when assayed on three different pharmacological preparations.(e) On thin-layer chromatography it behaved more like prostaglandin E(2) than E(1).4. Neither prostaglandin E(1) nor prostaglandin E(2) inhibited the release of free fatty acids from the rabbit epigastric fat pad by ACTH(1-24).5. It seems likely that prostaglandin E(2) is responsible for the vasodilatation accompanying fat mobilization from adipose tissue.
