1.
J Toxicol Environ Health
; 34(4): 485-94, 1991 Dec.
Article
in English
| MEDLINE
| ID: mdl-1960763
ABSTRACT
Five pesticides [amitraz, cyanazine, cyhexatin, dinitro-o-cresol (DNOC), and fenarimol] were tested as pure active ingredients for in vivo induction of DNA strand breaks on rat hepatocytes after intraperitoneal (ip) treatment. Two pesticides, fenarimol and DNOC, were capable of inducing DNA damage because they significantly increased the DNA unwinding rate. On the contrary, amitraz, cyanazine, and cyhexatin were not DNA-damaging agents.
Subject(s)
DNA Damage , Dinitrocresols/toxicity , Fungicides, Industrial/toxicity , Pesticides/toxicity , Pyrimidines/toxicity , Animals , Cell Nucleus/drug effects , Cell Nucleus/ultrastructure , Dinitrocresols/administration & dosage , Dose-Response Relationship, Drug , Fluorometry , Fungicides, Industrial/administration & dosage , Injections, Intraperitoneal , Insecticides/administration & dosage , Insecticides/toxicity , Liver/drug effects , Liver/ultrastructure , Male , Pyrimidines/administration & dosage , Rats , Rats, Inbred Strains , Toluidines/administration & dosage , Toluidines/toxicity , Trialkyltin Compounds/administration & dosage , Trialkyltin Compounds/toxicity , Triazines/administration & dosage , Triazines/toxicity
2.
Pol J Pharmacol Pharm
; 26(5): 485-91, 1974.
Article
in English
| MEDLINE
| ID: mdl-4427808
