ABSTRACT
A toxicological investigation of urine could finally explain abnormal neurological symptoms with apnea. 2 Cibalen-suppositories for children were given to an 7 week old infant as treatment of an upper respiratory infect. 12 hours were between the application of the 2 suppositories. 2 hours after the second application coma, hypertonus, opisthotonus, miosis and depression of ventilation were found. 10 hours later an apnea occurred. These symptoms were due to the synergistic effect of Phenobarbital, Aminophenazon and Codeinphosphat in an overhigh dose.
Subject(s)
Aminopyrine/poisoning , Barbiturates/poisoning , Codeine/poisoning , Diphenylacetic Acids/poisoning , Respiratory Insufficiency/chemically induced , Respiratory Tract Infections/drug therapy , Aminopyrine/administration & dosage , Aminopyrine/adverse effects , Barbiturates/administration & dosage , Barbiturates/adverse effects , Codeine/administration & dosage , Codeine/adverse effects , Diphenylacetic Acids/adverse effects , Drug Combinations/adverse effects , Drug Combinations/poisoning , Humans , Infant , Male , SuppositoriesABSTRACT
The case histories are presented of 6 patients with accidental poisoning by Spasmoplus suppositories. The main toxic constituents are codeine and the pyrazolone derivative, propyphenazone. All patients had symptoms of codeine intoxication with somnolence, miosis and oedema, 2 patients had also symptoms of prophyphenazone intoxication with hypotension, coma and convulsions. 1 patient died during the acute stage in a state of shock, with arrhythmia, and asystole.
