ABSTRACT
Esophageal malformations are rare and can occur sporadically or as a component of various syndromes. The variations and classifications are manifold. With the available modern operation techniques most malformations can be resolved with good results. However, esophageal malformations are often combined with further malformations which limit the prognosis. The separation of the trachea and esophagus after gastrulation is not yet completely researched. The results so far indicate that the localized expression of various homeodomain transcription factors is essential for normal development of the trachea and esophagus.
Subject(s)
Esophagus/abnormalities , Esophagus/pathology , Anastomosis, Surgical , Diseases in Twins/diagnosis , Diseases in Twins/genetics , Diseases in Twins/pathology , Diseases in Twins/surgery , Diverticulum, Esophageal/diagnosis , Diverticulum, Esophageal/genetics , Diverticulum, Esophageal/pathology , Diverticulum, Esophageal/surgery , Esophageal Atresia/diagnosis , Esophageal Atresia/genetics , Esophageal Atresia/pathology , Esophageal Atresia/surgery , Esophagus/embryology , Esophagus/surgery , Female , Genetic Loci/genetics , Humans , Infant , Infant, Newborn , Male , Phenotype , Prognosis , Syndrome , Trachea/abnormalities , Trachea/embryology , Trachea/pathology , Trachea/surgery , Tracheoesophageal Fistula/diagnosis , Tracheoesophageal Fistula/genetics , Tracheoesophageal Fistula/pathology , Tracheoesophageal Fistula/surgeryABSTRACT
A third pediatric case of intramural diverticulosis of the esophagus is reported in an 8-year-old boy. A hiatal hernia, chronic nonspecific esophagitis and defective esophageal motility was also documented in his 10-year-old brother.
