ABSTRACT
The results of radiation therapy in 31 patients with intracranial germ cell tumors have been analyzed. The five-year survival rates were 70.1% for germinomas and 38.1% for teratomas. Three patients with germinoma have since died of spinal seeding. The prophylactic irradiation of the spinal canal has been found effective in protecting spinal seeding, since no relapse of germinoma has been observed in cases that received entire neuraxis irradiation, whereas teratomas and marker (AFP, HCG) positive tumors did not respond favorably to radiation therapy, and the cause of death in these patients has been local failure. Long-term survivors over 3 years after radiation therapy have been determined as having a good quality of life.
Subject(s)
Brain Neoplasms/radiotherapy , Neoplasms, Germ Cell and Embryonal/radiotherapy , Adolescent , Adult , Brain Neoplasms/mortality , Brain Neoplasms/rehabilitation , Dysgerminoma/mortality , Dysgerminoma/radiotherapy , Dysgerminoma/rehabilitation , Female , Humans , Male , Middle Aged , Neoplasms, Germ Cell and Embryonal/mortality , Neoplasms, Germ Cell and Embryonal/rehabilitation , Prognosis , Quality of Life , Radiotherapy, High-Energy/mortality , Teratoma/mortality , Teratoma/radiotherapy , Teratoma/rehabilitationABSTRACT
Testicular cancer patients are at risk for sexual and marital problems because their cancer and its treatment reduce their fertility and disrupt intimate relationships at a crucial life stage (age 15-34). Chemotherapy, radiotherapy and surgery have successfully increased survival rates, but at the price of infertility and sexual dysfunction. A survey of men treated for nonseminomatous tumors revealed that 20% had low levels of sexual activity, 10% had erectile dysfunction, 6% had difficulty reaching orgasm, and 38% reported decreased orgasmic pleasure. Sexual anxiety related to cancer treatment accounts for much of this dysfunction, but organic factors such as hormonal, vascular or neurologic damage may also contribute. Reactions of couples to infertility and marital conflicts common in this group are discussed. Suggestions for sexual and marital counseling are offered.
