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1.
J Pak Med Assoc ; 72(3): 554-556, 2022 Mar.
Article in English | MEDLINE | ID: mdl-35320244

ABSTRACT

Several empirical researches imply that cognitive behaviour therapy can be effective in treating psychiatric disorders. In the context of Pakistan, some researches with Culturally Adapted Cognitive Behaviour Therapy were found to be effective for depression, anxiety, bipolar and psychotic disorders. The present study theoretically underpinned the model of Adapted Cognitive Behaviour Therapy (ACBT) based on the inclusion of Tasbeehs (Rosary) derived from the Quran and Sunnah to be fruitful in producing the desirable change in a single case of Dysthymia with anxious distress which was assessed with the help of the Urdu versions of Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Beck Hopelessness Scale (BHS) and Beck Scale for Suicidal Ideation (BSS). ACBT produced profound differences in pre-test and post-test scores in a patient. The Tasbeeh or Rosary could provide a therapeutic means for treating psychiatric illnesses irrespective of the religious and cultural differences.


Subject(s)
Cognitive Behavioral Therapy , Depressive Disorder , Anxiety Disorders/psychology , Depressive Disorder/psychology , Dysthymic Disorder/therapy , Humans , Psychiatric Status Rating Scales
2.
J Clin Psychol ; 77(2): 398-413, 2021 02.
Article in English | MEDLINE | ID: mdl-33476417

ABSTRACT

Intensive short-term dynamic psychotherapy (ISTDP) was developed to manage treatment impasses preventing the experiencing of feelings related to childhood attachment interruptions, such as parental loss. According to ISTDP theory, certain categories of patients will exhibit habitual patterns of responding within the treatment relationship (called defenses) to certain anxiety-provoking thoughts and feelings. Such defensive behaviors interrupt awareness of one's own feelings, self-directed compassion and engagement in close human attachments, including the bond with the therapist. Rupture-repair sequences in ISTDP are primarily considered in the context of a patient's defenses and the responses a therapist has to these defenses. By understanding and clarifying these defenses, this risk of subsequent misalliance, that is negative shifts or ruptures in the alliance, are minimized. In this paper we summarize ISTDP theory and technique through the use of clinical vignettes to illustrate defense management as a rupture-repair equivalent in ISTDP.


Subject(s)
Dysthymic Disorder/therapy , Emotions , Object Attachment , Psychotherapy, Brief , Psychotherapy, Psychodynamic , Therapeutic Alliance , Anxiety/psychology , Anxiety/therapy , Dysthymic Disorder/psychology , Humans , Male , Middle Aged
3.
Acta Neuropsychiatr ; 33(3): 126-133, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33427129

ABSTRACT

OBJECTIVE: To evaluate the use of biofeedback intervention in the levels of depression. The main hypothesis tested if the use of biofeedback improves depression levels compared to the control group. METHODS: A randomised clinical trial. The final sample was composed of 36 participants (18 in the experimental group, receiving 6 training, once a week, with biofeedback; and 18 in the control group, who received conventional treatment in the service).Outcome measures were assessed in two stages: pre-test and post-test. The research used the following instruments: demographic survey data, Mini International Neuropsychiatric Interview 5.0.0 and Beck Depression Inventory (BDI). The factors and variables were presented in terms of descriptive and inferential statistics. Fisher's exact test (p < 0.05) was used to verify the existence of an association between the counting variables. The multinomial logistic regression model was adopted, and the Logit link function was used, as the software RStudio version 3.6.2. RESULTS: The factors that remained in the final model were group, sex, partner, atypical antidepressant, benzodiazepines, mood stabiliser, antiepileptic and antihistamine, according to the levels of depression based on the BDI. The group that did not receive biofeedback intervention had 16 times more chances of increasing the depression levels compared to participants in the experimental group. CONCLUSION: The use of biofeedback reduces depression, thus, representing a complementary alternative for the treatment of moderate and severe depression, and dysthymia.


Subject(s)
Biofeedback, Psychology/methods , Depression/therapy , Psychiatric Status Rating Scales/standards , Adult , Antidepressive Agents/therapeutic use , Case-Control Studies , Depression/drug therapy , Depression/epidemiology , Dysthymic Disorder/drug therapy , Dysthymic Disorder/epidemiology , Dysthymic Disorder/therapy , Female , Humans , Logistic Models , Male , Middle Aged , Outcome Assessment, Health Care , Prevalence , Risk Factors , Severity of Illness Index , Surveys and Questionnaires
4.
Lancet Psychiatry ; 7(9): 801-812, 2020 09.
Article in English | MEDLINE | ID: mdl-32828168

ABSTRACT

Persistent depressive disorder is a chronic mood disorder that is common and often more disabling than episodic major depression. In DSM-5, the term subsumes several chronic depressive presentations, including dysthymia with or without superimposed major depressive episodes, chronic major depression, and recurrent major depression without recovery between episodes. Dysthymia can be difficult to detect in psychiatric and primary care settings until it intensifies in the form of a superimposed major depressive episode. Although information is scarce concerning the cause of persistent depressive disorder including dysthymia, the causation is likely to be multifactorial. In this narrative Review, we discuss current knowledge about the nosology and neurobiological basis of dysthymia and persistent depressive disorder, emphasising a dimensional perspective based on course for further research. We also review new developments in psychotherapy and pharmacotherapy for persistent depressive disorder, and propose a tailored, modular approach to accommodate its multifaceted nature.


Subject(s)
Depressive Disorder, Major/diagnosis , Depressive Disorder, Major/therapy , Dysthymic Disorder/diagnosis , Dysthymic Disorder/therapy , Antidepressive Agents/therapeutic use , Chronic Disease , Combined Modality Therapy , Comorbidity , Depressive Disorder, Major/epidemiology , Diagnostic and Statistical Manual of Mental Disorders , Dysthymic Disorder/epidemiology , Humans , Psychotherapy/methods , Recurrence
5.
J Med Internet Res ; 22(7): e15361, 2020 07 14.
Article in English | MEDLINE | ID: mdl-32673233

ABSTRACT

BACKGROUND: An increasing number of studies suggest that web-based interventions for patients with depression can reduce their symptoms and are expected to fill currently existing treatment gaps. However, evidence for their efficacy has mainly been derived from comparisons with wait-list or treatment as usual controls. In particular, designs using wait-list controls are unlikely to induce hope and may even have nocebo effects, making it difficult to draw conclusions about the intervention's efficacy. Studies using active controls are rare and have not yielded conclusive results. OBJECTIVE: The main objective of this study is to assess the acute and long-term antidepressant efficacy of a 6-week, guided, web-based self-management intervention building on the principles of cognitive behavioral therapy (iFightDepression tool) for patients with depression compared with web-based progressive muscle relaxation as an active control condition. METHODS: A total of 348 patients with mild-to-moderate depressive symptoms or dysthymia (according to the Mini International Neuropsychiatric Interview) were recruited online and randomly assigned to 1 of the 2 intervention arms. Acute antidepressant effects after 6 weeks and long-term effects at 3-, 6-, and 12-month follow-up were studied using the Inventory of Depressive Symptomatology-self-rating as a primary outcome parameter and change in quality of life (Short Form 12) and user satisfaction (client satisfaction questionnaire) as secondary outcome parameters. Treatment effects were assessed using mixed model analyses. RESULTS: Over the entire observation period, a greater reduction in symptoms of depression (P=.01) and a greater improvement of life quality (P<.001) was found in the intervention group compared with the active control group. Separate tests for each time point revealed significant effects on depressive symptoms at the 3-month follow-up (d=0.281; 95% CI 0.069 to 0.493), but not after 6 weeks (main outcome:d=0.192; 95% CI -0.020 to 0.404) and 6 and 12 months. The intervention was significantly superior to the control condition with respect to user satisfaction (25.31 vs 21.97; t259=5.804; P<.01). CONCLUSIONS: The fact that antidepressant effects have been found for a guided self-management tool in comparison with an active control strengthens the evidence base for the efficacy of web-based interventions. The antidepressant effect became most prominent at the 3-month follow-up. After 6 weeks of intervention, significant positive effects were observed on life quality but not on depressive symptoms. Although the effect size of such web-based interventions on symptoms of depression might be smaller than that suggested by earlier studies using wait-list control conditions, they can be a cost-effective addition to antidepressants and face-to-face psychotherapy. TRIAL REGISTRATION: International Clinical Trials Registry Platform ICTRP080-15-09032015; https://apps.who.int/trialsearch/Trial2.aspx?TrialID=DRKS00009323.


Subject(s)
Depression/therapy , Dysthymic Disorder/therapy , Internet-Based Intervention/statistics & numerical data , Psychotherapy/methods , Quality of Life/psychology , Self-Management/methods , Adult , Female , Follow-Up Studies , Humans , Male , Time Factors
6.
Behav Res Ther ; 131: 103625, 2020 08.
Article in English | MEDLINE | ID: mdl-32353635

ABSTRACT

This study examined the feasibility, acceptability, and preliminary efficacy of a decision rule driven treatment for youth with comorbid conduct problems and depression. A randomized, controlled, repeated measures design was used to compare two treatment approaches: Decision-Rule Based Treatment (DR) and Sequential Treatment (SEQ). Participants included 30 children (ages 8-14; 66% female; 80% Caucasian) who met criteria for a depressive disorder (major depressive disorder and/or dysthymia) and a conduct problem disorder (oppositional defiant disorder and/or conduct disorder). Assessments were conducted at baseline, post-treatment, and six-month follow-up. Treatment adherence, attendance, and session evaluations ratings indicate that the treatments were feasible to implement and acceptable to parents and youth in both conditions. Both treatments showed similar remission of internalizing and externalizing diagnoses. Participants in DR showed significantly greater improvements at six-month follow-up in child-reported depressive symptom severity compared to SEQ. Both DR and SEQ conditions showed significantly lower behavior problems at end of treatment and six-month follow-up. DR showed significant reductions in emotion dysregulation at 6-month follow-up, while SEQ did not. Findings suggest that a decision rule based intervention holds promise as a feasible and acceptable treatment with high rates of remittance.


Subject(s)
Attention Deficit and Disruptive Behavior Disorders/therapy , Cognitive Behavioral Therapy/methods , Decision Support Systems, Clinical , Depressive Disorder/therapy , Emotional Regulation , Adolescent , Attention Deficit and Disruptive Behavior Disorders/psychology , Child , Comorbidity , Conduct Disorder/psychology , Conduct Disorder/therapy , Depressive Disorder/psychology , Depressive Disorder, Major/psychology , Depressive Disorder, Major/therapy , Dysthymic Disorder/psychology , Dysthymic Disorder/therapy , Feasibility Studies , Female , Humans , Male , Parents/education , Patient Acceptance of Health Care , Pilot Projects , Treatment Outcome
7.
BMC Psychiatry ; 19(1): 90, 2019 03 14.
Article in English | MEDLINE | ID: mdl-30871544

ABSTRACT

BACKGROUND: The treatment of major depressive disorder, a highly prevalent disorder associated with pronounced burden, is a large challenge to healthcare systems worldwide. Internet based self-management interventions seem to be a cost effective way to complement the treatment of depressed patients, but the accumulating evidence is mainly based on the comparison to waitlist controls and treatment as usual, which might lead to an overestimation of effects. Furthermore, studies assessing long-term effects and possible negative outcomes are still rare. METHODS/DESIGN: The proposed study evaluates the efficacy of the German version of the iFightDepression® tool in comparison to an active control condition. A total of 360 patients with mild to moderate depressive symptoms are included into a two-armed randomized controlled trial. They receive one of two six week interventions; either the iFightDepression® tool or progressive muscle relaxation serving as the control condition. Both intervention groups receive information material, weekly tasks via the internet and regular phone calls as part of the intervention. The primary outcome is change in depressive symptoms after the intervention period, as measured with the Inventory of Depressive Symptomatology. Satisfaction with the program, usability, changes in perceived quality of life, and possible negative effects are assessed as secondary outcomes. DISCUSSION: This study represents the first randomized controlled trial on the iFightDepression® self-management tool in its German version, aiming at efficacy, but also at providing new insights into so far understudied aspects of E-mental health programs, namely the specificity of the treatment effect compared to an active control condition, it's continuity over a time course of 12 months, and possible negative effects of these internet based interventions. TRIAL REGISTRATION: International trial-registration took place through the "international clinical trials registry platform" (WHO) with the secondary ID 080-15-09032015. German Clinical Trial Registration: DRKS00009323 (DRKS.de, registered on 25 February 2016).


Subject(s)
Depressive Disorder, Major/psychology , Depressive Disorder, Major/therapy , Dysthymic Disorder/psychology , Dysthymic Disorder/therapy , Internet-Based Intervention , Self-Management/psychology , Adult , Depressive Disorder, Major/epidemiology , Dysthymic Disorder/epidemiology , Female , Humans , Male , Quality of Life/psychology , Self-Management/methods , Treatment Outcome
8.
Behav Cogn Psychother ; 47(2): 244-250, 2019 Mar.
Article in English | MEDLINE | ID: mdl-29692278

ABSTRACT

BACKGROUND: Based on the vulnerability model, several studies indicate that low self-esteem seems to contribute to depressive symptoms. AIMS: The aim of this study was to treat depressive symptoms in a cognitive behavioural group therapy, focusing on the enhancement of self-esteem, and to explore co-variation in depressive symptoms and the level of self-esteem. METHOD: The Multidimensional Self-esteem Scale (MSWS) and the Beck Depression Inventory (BDI) were administered to 147 psychiatric in-patients with current depressive symptoms due to an affective disorder (major depression, bipolar I, dysthymia). Self-esteem was measured pre-treatment (t0) and post-treatment (t4, after 5 weeks of eight group sessions); the BDI was applied weekly. A linear mixed growth analysis was conducted to estimate the change in depressive symptoms including interactions with self-esteem. RESULTS: Within the 5 weeks of group therapy, depressive symptoms showed a linear decline, which was stronger for patients with higher gains in self-esteem between t0 and t4. Self-esteem at t0 was unrelated to the change in depression but predicted self-esteem at t4. CONCLUSIONS: Treating depressive symptoms in a cognitive behavioural group therapy in a naturalistic setting might have a positive effect on the process of recovery. Moreover, depressive symptoms and level of self-esteem seemed to co-vary.


Subject(s)
Cognitive Behavioral Therapy , Depression/psychology , Depression/therapy , Psychotherapy, Group , Self Concept , Adult , Bipolar Disorder/psychology , Bipolar Disorder/therapy , Depressive Disorder, Major/psychology , Depressive Disorder, Major/therapy , Dysthymic Disorder/psychology , Dysthymic Disorder/therapy , Female , Humans , Longitudinal Studies , Male , Mood Disorders/psychology , Mood Disorders/therapy , Psychiatric Status Rating Scales
9.
Depress Anxiety ; 35(10): 966-973, 2018 10.
Article in English | MEDLINE | ID: mdl-30028564

ABSTRACT

BACKGROUND: Although there is a growing interest in the role of attentional biases in depression, there are no studies assessing changes in these biases after psychotherapeutic interventions. METHODS: We used a validated eye-tracking procedure to assess pre-post therapy changes in attentional biases toward emotional information (i.e., happy, sad, and angry faces) when presented with neutral information (i.e., neutral faces). The sample consisted of 75 participants with major depression or dysthymia. Participants were blindly assigned to one of two 10 weekly sessions of group therapy: a cognitive behavior therapy intervention (N = 41) and a positive psychology intervention (N = 34). RESULTS: Both treatments were equally efficacious in improving depressive symptoms (p = .0001, η² = .68). A significant change in attentional performance after therapy was observed irrespective of the intervention modality. Comparison of pre-post attentional measures revealed a significant reduction in the total time of fixations (TTF) looking at negative information (i.e., sad and angry faces) and a significant increase in the TTF looking at positive information (i.e., happy faces)-all p < .02. CONCLUSIONS: Findings reveal for the first time that psychotherapeutic interventions are associated with a significant change in attentional biases as assessed by a direct measure of attention. Furthermore, these changes seem to operate in the same direction typically found in healthy populations (i.e., a bias away from negative information and a parallel bias toward positive information). These findings illustrate the importance of considering attentional biases as clinical markers of depression and suggest the viability of modifying these biases as a potential tool for clinical change.


Subject(s)
Attentional Bias , Cognitive Behavioral Therapy/methods , Depressive Disorder, Major/therapy , Dysthymic Disorder/therapy , Adult , Anger , Attention , Depression/psychology , Depressive Disorder, Major/physiopathology , Depressive Disorder, Major/psychology , Dysthymic Disorder/physiopathology , Dysthymic Disorder/psychology , Emotions , Eye Movement Measurements , Eye Movements , Facial Expression , Female , Happiness , Humans , Middle Aged , Psychotherapy/methods
10.
Int J Psychiatry Clin Pract ; 22(4): 268-273, 2018 Nov.
Article in English | MEDLINE | ID: mdl-29334283

ABSTRACT

Objective: The objective of this study is to assess the impact of an 8-week physical training program on physiological, biological and psychological profiles in individual with mood disorders. Methods: Seven patients participated in the study. Patients were trained twice weekly (75 min/session) for 8 weeks. The training program aimed to improve muscular and cardiorespiratory reserves as well as functional capacity. Bioassays were also measured (lipid profile, blood glucose and cortisol). Depression, sleep quality and body image dissatisfaction were assessed. All measures were administrated at pre/post-intervention. Results: At post-intervention, 13 of the 15 physiological fitness, muscular strength and functional capacity variables improved significantly (p < .05). In addition, change in cortisol levels represented a medium to large effect size (Cohen's d = -0.67) which indicates a clinical reduction of stress-related symptoms. Depression was significantly improved (Cohen's d = -0.47; p = .027). Sleep and body image showed a trend-level improvement. Conclusions: An 8-week periodised training program improved physiological, biological and psychological profiles in patients with mood disorders.


Subject(s)
Bipolar Disorder/therapy , Dysthymic Disorder/therapy , Exercise Therapy/methods , Hydrocortisone/blood , Muscle Strength/physiology , Outcome Assessment, Health Care , Personal Satisfaction , Physical Fitness/physiology , Stress, Psychological/therapy , Adult , Body Image , Humans , Middle Aged , Pilot Projects , Sleep Wake Disorders/therapy , Stress, Psychological/blood , Young Adult
11.
Span J Psychol ; 20: E52, 2017 Oct 26.
Article in English | MEDLINE | ID: mdl-29072149

ABSTRACT

Research on psychotherapy has traditionally focused on analyzing changes between the beginning and the end of a treatment. Few studies have addressed the pattern of therapeutic change during treatment. The aim of this study was to examine the pattern of changes in clinical and well-being variables during a cognitive behavioral therapy (CBT) program compared with an integrative positive psychology interventions program for clinical depression IPPI-D. 128 women with a diagnosis of major depression or dysthymia were assigned to the CBT or PPI group. A measure of depressive symptoms (i.e., Beck Depression Inventory) and well-being (i.e., Pemberton Happiness Index) were administered four times: at the beginning and end of the treatment, as well as during treatment (at sessions 4 and 7). Through mixed-model repeated measures ANOVAs, both depressive symptoms (p .08). The percentage of improvement in depressive symptoms in the first treatment period was higher than in the later ones (ps < .005). On the contrary, well-being showed a more gradual improvement (p = .15). These results highlight the importance of assessing the pattern of changes in symptoms and well-being separately.


Subject(s)
Cognitive Behavioral Therapy/methods , Depressive Disorder, Major/therapy , Dysthymic Disorder/therapy , Outcome Assessment, Health Care , Psychotherapeutic Processes , Psychotherapy/methods , Adult , Female , Humans
12.
J Diabetes Complications ; 31(11): 1571-1579, 2017 Nov.
Article in English | MEDLINE | ID: mdl-28893494

ABSTRACT

AIMS: Information on the burden and risk factors for diabetes-depression comorbidity in the US is sparse. We used data from the largest all-payer, nationally-representative inpatient database in the US to estimate the prevalence, temporal trends, and risk factors for comorbid depression among adult diabetic inpatients. METHODS: We conducted a retrospective analysis using the 2002-2014 Nationwide Inpatient Sample databases. Depression and other comorbidities were identified using ICD-9-CM codes. Logistic regression was used to investigate the association between patient characteristics and depression. RESULTS: The rate of depression among patients with type 2 diabetes increased from 7.6% in 2002 to 15.4% in 2014, while for type 1 diabetes the rate increased from 8.7% in 2002 to 19.6% in 2014. The highest rates of depression were observed among females, non-Hispanic whites, younger patients, and patients with five or more chronic comorbidities. CONCLUSIONS: The prevalence of comorbid depression among diabetic inpatients in the US is increasing rapidly. Although some portion of this increase could be explained by the rising prevalence of multimorbidity, increased awareness and likelihood of diagnosis of comorbid depression by physicians and better documentation as a result of the increased adoption of electronic health records likely contributed to this trend.


Subject(s)
Adjustment Disorders/epidemiology , Depressive Disorder/epidemiology , Diabetes Complications/psychology , Diabetes Mellitus, Type 1/psychology , Diabetes Mellitus, Type 2/psychology , Health Transition , Personality Disorders/epidemiology , Adjustment Disorders/therapy , Adult , Age Factors , Cohort Studies , Comorbidity , Cross-Sectional Studies , Depressive Disorder/therapy , Depressive Disorder, Major/epidemiology , Depressive Disorder, Major/therapy , Diabetes Complications/complications , Diabetes Complications/epidemiology , Diabetes Complications/therapy , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/epidemiology , Diabetes Mellitus, Type 1/therapy , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/epidemiology , Diabetes Mellitus, Type 2/therapy , Dysthymic Disorder/epidemiology , Dysthymic Disorder/therapy , Female , Hospitalization , Humans , Insurance, Health, Reimbursement , Male , Personality Disorders/therapy , Prevalence , Retrospective Studies , Risk Factors , Sex Factors , United States/epidemiology
13.
Psychiatr Serv ; 68(11): 1164-1171, 2017 Nov 01.
Article in English | MEDLINE | ID: mdl-28669288

ABSTRACT

OBJECTIVE: Effectiveness of collaborative care for perinatal depression has been demonstrated for MOMCare, from early pregnancy up to 15 months postpartum, for Medicaid enrollees in a public health system. MOMCare had a greater impact on reducing depression and improving functioning for women with comorbid posttraumatic stress disorder (PTSD) than for those without PTSD. This study estimated the incremental benefit and cost and the net benefit of MOMCare for women with major depression and PTSD. METHODS: A randomized trial (September 2009 to December 2014) compared the MOMCare collaborative care depression intervention (choice of brief interpersonal psychotherapy or pharmacotherapy or both) with enhanced maternity support services (MSS-Plus) in the public health system of Seattle-King County. Among pregnant women with a probable diagnosis of major depression or dysthymia (N=164), two-thirds (N=106) met criteria for probable PTSD. Blinded assessments at three, six, 12, and 18 months postbaseline included the Symptom Checklist-20 depression scale and the Cornell Services Index. Analyses of covariance estimated gain in depression free days (DFDs) by intervention and PTSD status. RESULTS: When the analysis controlled for baseline depression severity, women with probable depression and PTSD in MOMCare had 68 more depression-free days over 18 months than those in MSS-Plus (p<.05). The additional depression care cost per MOMCare participant with comorbid PTSD was $1,312. The incremental net benefit of MOMCare was positive if a DFD was valued at ≥$20. CONCLUSIONS: For women with probable major depression and PTSD, MOMCare had significant clinical benefit over MSS-Plus, with only a moderate increase in health services cost.


Subject(s)
Antidepressive Agents/therapeutic use , Community Health Services/methods , Cost-Benefit Analysis , Depressive Disorder, Major/therapy , Dysthymic Disorder/therapy , Outcome Assessment, Health Care , Poverty , Pregnancy Complications/therapy , Psychotherapy, Brief/methods , Stress Disorders, Post-Traumatic/therapy , Adult , Antidepressive Agents/economics , Community Health Services/economics , Comorbidity , Depressive Disorder, Major/economics , Depressive Disorder, Major/epidemiology , Dysthymic Disorder/drug therapy , Dysthymic Disorder/economics , Dysthymic Disorder/epidemiology , Female , Humans , Intersectoral Collaboration , Outcome Assessment, Health Care/economics , Pregnancy , Pregnancy Complications/economics , Pregnancy Complications/epidemiology , Psychotherapy, Brief/economics , Stress Disorders, Post-Traumatic/economics , Stress Disorders, Post-Traumatic/epidemiology , Vulnerable Populations , Young Adult
15.
JAMA Psychiatry ; 74(3): 233-242, 2017 Mar 01.
Article in English | MEDLINE | ID: mdl-28146251

ABSTRACT

IMPORTANCE: Chronic depression is a highly prevalent and disabling disorder. There is a recognized need to assess the value of long-term disorder-specific psychotherapy. OBJECTIVE: To evaluate the efficacy of the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) compared with that of nonspecific supportive psychotherapy (SP). DESIGN, SETTING, AND PARTICIPANTS: A prospective, multicenter, evaluator-blinded, randomized clinical trial was conducted among adult outpatients with early-onset chronic depression who were not taking antidepressant medication. Patients were recruited between March 5, 2010, and October 16, 2012; the last patient finished treatment on October 14, 2013. Data analysis was conducted from March 5, 2014, to October 27, 2016. INTERVENTIONS: The treatment included 24 sessions of CBASP or SP for 20 weeks in the acute phase, followed by 8 continuation sessions during the next 28 weeks. MAIN OUTCOMES AND MEASURES: The primary outcome was symptom severity after 20 weeks (blinded observer ratings) as assessed by the 24-item Hamilton Rating Scale for Depression (HRSD-24). Secondary outcomes were rates of response (reduction in HRSD-24 score of ≥50% from baseline) and remission (HRSD-24 score ≤8), as well as self-assessed ratings of depression, global functioning, and quality of life. RESULTS: Among 622 patients assessed for eligibility, 268 were randomized: 137 to CBASP (96 women [70.1%] and 41 men [29.9%]; mean [SD] age, 44.7 [12.1] years) and 131 to SP (81 women [61.8%] and 50 men [38.2%]; mean [SD] age, 45.2 [11.6] years). The mean (SD) baseline HRSD-24 scores of 27.15 (5.49) in the CBASP group and 27.05 (5.74) in the SP group improved to 17.19 (10.01) and 20.39 (9.65), respectively, after 20 weeks, with a significant adjusted mean difference of -2.51 (95% CI, -4.16 to -0.86; P = .003) and a Cohen d of 0.31 in favor of CBASP. After 48 weeks, the HRSD-24 mean (SD) scores were 14.00 (9.72) for CBASP and 16.49 (9.96) for SP, with an adjusted difference of -3.13 (95% CI, -5.01 to -1.25; P = .001) and a Cohen d of 0.39. Patients undergoing CBASP were more likely to reach response (48 of 124 [38.7%] vs 27 of 111 [24.3%]; adjusted odds ratio, 2.02; 95% CI, 1.09 to 3.73; P = .03) or remission (27 of 124 [21.8%] vs 14 of 111 [12.6%]; adjusted odds ratio, 3.55; 95% CI, 1.61 to 7.85; P = .002) after 20 weeks. Patients undergoing CBASP showed significant advantages in most other secondary outcomes. CONCLUSIONS AND RELEVANCE: Highly structured specific psychotherapy was moderately more effective than nonspecific therapy in outpatients with early-onset chronic depression who were not taking antidepressant medication. Adding an extended phase to acute psychotherapy seems promising in this population. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00970437.


Subject(s)
Cognitive Behavioral Therapy/methods , Depressive Disorder, Major/therapy , Psychotherapy/methods , Adult , Ambulatory Care , Chronic Disease , Comorbidity , Depressive Disorder, Major/diagnosis , Depressive Disorder, Major/psychology , Dysthymic Disorder/diagnosis , Dysthymic Disorder/psychology , Dysthymic Disorder/therapy , Female , Humans , Male , Middle Aged
16.
Clin Psychol Psychother ; 24(1): 212-225, 2017 Jan.
Article in English | MEDLINE | ID: mdl-26750303

ABSTRACT

OBJECTIVES: New research-informed methods for case conceptualization that cut across traditional therapy approaches are increasingly popular. This paper presents a trans-theoretical approach to case formulation based on the research observations of emotion. METHODS: The sequential model of emotional processing (Pascual-Leone & Greenberg, 2007) is a process research model that provides concrete markers for therapists to observe the emerging emotional development of their clients. We illustrate how this model can be used by clinicians to track change and provides a 'clinical map,' by which therapist may orient themselves in-session and plan treatment interventions. RESULTS: Emotional processing offers as a trans-theoretical framework for therapists who wish to conduct emotion-based case formulations. First, we present criteria for why this research model translates well into practice. Second, two contrasting case studies are presented to demonstrate the method. CONCLUSIONS: The model bridges research with practice by using client emotion as an axis of integration. Key Practitioner Message Process research on emotion can offer a template for therapists to make case formulations while using a range of treatment approaches. The sequential model of emotional processing provides a 'process map' of concrete markers for therapists to (1) observe the emerging emotional development of their clients, and (2) help therapists develop a treatment plan. Copyright © 2016 John Wiley & Sons, Ltd.


Subject(s)
Case Management , Emotions , Psychotherapy , Adaptation, Psychological , Adult , Anger , Depressive Disorder, Major/diagnosis , Depressive Disorder, Major/psychology , Depressive Disorder, Major/therapy , Dysthymic Disorder/diagnosis , Dysthymic Disorder/psychology , Dysthymic Disorder/therapy , Female , Humans , Life Change Events , Models, Psychological , Patient Care Planning , Psychological Theory , Reactive Attachment Disorder/diagnosis , Reactive Attachment Disorder/psychology , Reactive Attachment Disorder/therapy , Research , Substance-Related Disorders/diagnosis , Substance-Related Disorders/psychology , Substance-Related Disorders/therapy
17.
Psychother Res ; 27(4): 488-500, 2017 07.
Article in English | MEDLINE | ID: mdl-26776721

ABSTRACT

OBJECTIVE: Several randomized controlled trials have identified early response to psychotherapy as a predictor for later treatment outcome among patients with depressive disorders. However, supporting evidence under routine conditions is rare. This study evaluated the predictive value of early improvement for final outcomes in psychotherapy among depressive patients in the naturalistic setting of a German university outpatient clinic. METHOD: We used the method of percent symptom reduction to classify 639 patients with major depression or dysthymic disorder who underwent an average of 40.0 sessions (SD = 16.3) of naturalistic cognitive-behavioral therapy (CBT) as having either an early response or an early nonresponse. RESULTS: Early response was a good predictor for final response and remission regarding depressive symptoms (OR = 8.75 and OR = 5.32, respectively), as well as overall psychological distress (OR = 3.95 and OR = 3.16, respectively). Early nonresponse was distinctly associated with later deterioration of both depressive (OR = 9.56) and general psychological symptomatology (OR = 4.92). CONCLUSIONS: Early response to psychotherapy has high predictive qualities for positive later treatment outcome in depressive patients under routine CBT. Therefore, early treatment effects should be considered in clinical decision-making and treatment planning in everyday clinical practice.


Subject(s)
Cognitive Behavioral Therapy/methods , Depressive Disorder, Major/therapy , Dysthymic Disorder/therapy , Outcome Assessment, Health Care/methods , Adult , Female , Humans , Male , Middle Aged , Time Factors
18.
Psychiatr Serv ; 68(1): 17-24, 2017 01 01.
Article in English | MEDLINE | ID: mdl-27691376

ABSTRACT

OBJECTIVE: The study examined the effectiveness of a perinatal collaborative care intervention in moderating the effects of adverse neonatal birth events on risks of postpartum depressive symptoms and impaired functioning among women of lower socioeconomic status with antenatal depression. METHODS: A randomized controlled trial with blinded outcome assessments was conducted in ten public health centers, comparing MOMCare (choice of brief interpersonal psychotherapy, pharmacotherapy, or both) with intensive maternity support services (MSS-Plus). Participants had probable diagnoses of major depressive disorder or dysthymia during pregnancy. Generalized estimating equations estimated differences in depression and functioning measures between groups with and without adverse birth events within the treatment arms. A total of 160 women, 43% of whom experienced at least one adverse birth event, were included in the analyses. RESULTS: For women who received MOMCare, postpartum depression scores (measured with the Symptom Checklist-20) did not differ by whether or not they experienced an adverse birth event (mean±SD scores of .86±.51 for mothers with an adverse birth event and .83±.56 for mothers with no event; p=.78). For women who received MSS-Plus, having an adverse birth event was associated with persisting depression in the postpartum period (mean scores of 1.20±.0.61 for mothers with an adverse birth event and .93±.52 for mothers without adverse birth event; p=.04). Similar results were seen for depression response rates and functioning. CONCLUSIONS: MOMCare mitigated the risk of postpartum depressive symptoms and impaired functioning among women of low socioeconomic status who had antenatal depression and who experienced adverse birth events.


Subject(s)
Depression, Postpartum/therapy , Depressive Disorder, Major/therapy , Dysthymic Disorder/therapy , Intersectoral Collaboration , Maternal Health Services , Outcome Assessment, Health Care , Pregnancy Complications/therapy , Pregnancy Outcome , Adolescent , Adult , Depression, Postpartum/drug therapy , Depression, Postpartum/epidemiology , Depressive Disorder, Major/drug therapy , Depressive Disorder, Major/epidemiology , Dysthymic Disorder/drug therapy , Dysthymic Disorder/epidemiology , Female , Humans , Maternal Health Services/organization & administration , Medicaid/statistics & numerical data , Obstetric Labor Complications/epidemiology , Pregnancy , Pregnancy Complications/drug therapy , Pregnancy Complications/epidemiology , Pregnancy Outcome/epidemiology , Psychotherapy, Brief/methods , United States/epidemiology , Vulnerable Populations , Young Adult
19.
J Clin Psychiatry ; 77(9): e1154, 2016 09.
Article in English | MEDLINE | ID: mdl-27780329

ABSTRACT

Many patients will not respond adequately to their initial trial of antidepressant medication or subsequent trials. By identifying features that can signal potential treatment-resistant or difficult-to-treat depression early in the course of illness, clinicians may be able to find the right balance of treatment strategies to help patients achieve remission. Here, follow the case of Alice, a 32-year-old lawyer with a treatment-resistant depressive episode.


Subject(s)
Depressive Disorder, Treatment-Resistant/diagnosis , Depressive Disorder, Treatment-Resistant/therapy , Adult , Delusions/diagnosis , Delusions/therapy , Dysthymic Disorder/diagnosis , Dysthymic Disorder/therapy , Female , Humans , Risk Factors
20.
Psychotherapy (Chic) ; 53(3): 297-301, 2016 Sep.
Article in English | MEDLINE | ID: mdl-27631858

ABSTRACT

Although supportive-expressive (SE) psychotherapy is one of the most studied psychodynamic therapies today, little is known empirically about effective strategies in SE supervision, or in psychodynamic supervision in general (Diener & Mesrie, 2015; Watkins, 2011). One of the important questions in SE psychotherapy is how to decide when to use supportive and when to use expressive interventions. As a parallel process, this type of decision is relevant also to SE supervision. The present case study focuses on the decision-making process in an SE supervision session: when should supervisors use supportive as opposed to expressive strategies with their supervisees? Our aim is to develop decision rules that reliably support supervisors' decisions. We analyze a clinical error made by supervisors in this type of decision making, and show how mistakes of this type can either be avoided or, when they occur, how to turn them into opportunities for learning and for the formation of new understanding and growth. Similarly to the finding that therapists with better skills in managing their countertransference feelings were shown to have better outcomes with their patients (Gelso, Latts, Gomez, & Fassinger, 2002; Hayes, Gelso, & Hummel, 2011), we suggest that the management of the supervisors' feelings, and working through their mistakes with the therapists, can contribute to the supervisory relationship and to the development of the psychodynamic therapists' skills. (PsycINFO Database Record


Subject(s)
Feedback , Medical Errors , Mentors , Psychotherapeutic Processes , Psychotherapy, Psychodynamic/education , Adult , Countertransference , Decision Making , Dysthymic Disorder/psychology , Dysthymic Disorder/therapy , Empathy , Female , Group Processes , Humans , Male , Object Attachment , Pilot Projects , Problem Solving , Professional-Patient Relations
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