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1.
J Pak Med Assoc ; 70(3): 537-538, 2020 Mar.
Article in English | MEDLINE | ID: mdl-32207443

ABSTRACT

Herpes zoster oticus (Ramsay Hunt Syndrome) is characterized by facial nerve paralysis, ear pain and auricular skin rash. It occurs as a result of reactivation oflatent varicella zoster virus infection in the geniculate ganglion of the facial nerve. Major clinical symptoms include 7th nerve paralysis or cranial nerve paralysis and vesicles along the nerve with cocomitant ear pain. Other cranial nerve involvement although uncommon, can be found in some cases. In this study, a 74-year-old female patient had ipsilateral 8th, 9th and 10th cranial nerves injury. Cranial nerve paralysis accompanied with injury has been repor ted in R amsay Hunt Syndrome.


Subject(s)
Cranial Nerves , Diphenhydramine/administration & dosage , Herpes Zoster Oticus , Herpesvirus 3, Human/pathogenicity , Methylprednisolone/administration & dosage , Valacyclovir/administration & dosage , Aged , Antiemetics/administration & dosage , Antiviral Agents/administration & dosage , Cranial Nerves/physiopathology , Cranial Nerves/virology , Deglutition Disorders/diagnosis , Deglutition Disorders/etiology , Ear Auricle/physiopathology , Ear Auricle/virology , Facial Paralysis/diagnosis , Facial Paralysis/physiopathology , Facial Paralysis/virology , Female , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sensorineural/virology , Herpes Zoster Oticus/diagnosis , Herpes Zoster Oticus/drug therapy , Herpes Zoster Oticus/physiopathology , Humans , Neurologic Examination/methods , Physical Examination/methods , Treatment Outcome
3.
Methods Mol Biol ; 890: 147-59, 2012.
Article in English | MEDLINE | ID: mdl-22688766

ABSTRACT

Intradermal injection of vaccinia virus in the ear pinnae of mice provides a model of dermal infection and vaccination. The key features of this model are the appearance of a lesion on the surface of the ear that can be measured as a clinical sign of disease and substantial growth of virus in the infected skin in the absence of systemic spread. In addition, infected ears can be easily removed to allow virological, histological, and cellular analyses. Finally, evaluation of the roles of virus (and presumably also host) genes in vaccinia virus pathogenesis in the intradermal model can yield different results than similar experiments using other routes and may reveal otherwise unknown functions.


Subject(s)
Ear Auricle/virology , Skin Diseases, Infectious/virology , Vaccinia virus/physiology , Vaccinia/virology , Animals , Disease Models, Animal , Host-Pathogen Interactions , Injections, Intradermal , Mice , Mice, Inbred BALB C , Mice, Inbred C57BL , Vaccinia/pathology , Viral Load
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