ABSTRACT
INTRODUCTION: To create a scoring system by including all of the factors that are recommended for an ideal ET and to investigate its correlation with the Β-HCG results. MATERIALS AND METHODS: This study was conducted as a retrospective trial between January 2009 and December 2018. Women who had a single ET between the specified dates were included in the study. The embryo grade, ET day, distance between the fundus to embryo transfer site measured via ultrasonography, endometrial thickness on ET day, and presence of mucus and blood in the catheter after transfer were the variables evaluated. Each one of the five variables that constituted the scoring system were rated separately. RESULTS: Overall, 1652 patients participated in this research. Antral follicle count (13,3 ± 8 vs. 14,6 ± 8,2, p: 0,001), endometrial thickness on the ET day (9.9 ± 2 vs.10.3 ± 2, p = 0.006) and number of mature oocytes (8.6 ± 6 vs. 9 ± 5.1, p: 0.003) were significantly higher in patients with positive Β-HCG values. The total score in the Β-HCG positive group was 9.8 ± 1.4 versus 8.9 ± 1.4 in the Β-HCG negative group (p < 0.001). The best ETSS cut-off value for predicting Β-HCG positivity was 9.5, with 82% sensitivity and 67% specificity (AUC:0.808). CONCLUSION: Our scoring system is an important step toward standardization, as it offers a new, practical, cost-free, and applicable scoring system based on pre- and post-ET measurements and laboratory data.
Subject(s)
Embryo Transfer/classification , Research Design/standards , Adult , Chi-Square Distribution , Cohort Studies , Embryo Transfer/methods , Female , Fertilization in Vitro/classification , Fertilization in Vitro/methods , Humans , Retrospective Studies , Statistics, NonparametricABSTRACT
This document provides updated coding information for services related to assisted reproductive technology procedures. This document replaces the 2012 ASRM document of the same name.
Subject(s)
Clinical Coding/classification , Medical Laboratory Science/classification , Reproductive Techniques, Assisted/classification , Clinical Coding/standards , Embryo Transfer/classification , Embryo Transfer/standards , Humans , Medical Laboratory Science/standards , Reproductive Techniques, Assisted/standardsABSTRACT
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No disponible
Subject(s)
Female , Male , Humans , Embryonic Structures/anatomy & histology , Embryology/legislation & jurisprudence , Embryology/methods , Embryology/standards , Fertilization in Vitro/legislation & jurisprudence , Fetal Development/physiology , Fetal Development/genetics , Embryo Transfer/methods , Embryo Transfer/standards , Embryo Transfer , Cryopreservation/methods , Cryopreservation/standards , Cryopreservation , Reproductive Techniques/legislation & jurisprudence , Infertility , Embryo Transfer/classification , Embryo Transfer/statistics & numerical data , Pregnancy, Multiple/physiology , Pregnancy, Multiple/genetics , OocytesABSTRACT
OBJECTIVE: To investigate the impact of delaying the transfer of in vitro fertilized embryos to day 5 on embryo development by comparing serum beta-hCG levels in pregnancies established after day 3 embryo transfers and those after day 5 blastocyst transfers at equivalent time intervals after fertilization. DESIGN: A retrospective analysis. SETTING: Assisted reproductive technology center in an academic research environment. PATIENT(S): Women who had an embryo transfer procedure performed after in vitro fertilization (IVF) at Northwestern University's IVF Program between January 1999 and December 2001 were included in this study. INTERVENTION(S): Embryo transfer was performed either on day 3 or day 5 after oocyte retrieval for IVF (day 0), depending on the availability of good-quality embryos on day 3. MAIN OUTCOME MEASURE(S): Serum beta-hCG concentrations determined 13 and 15 days after fertilization in pregnancies established by transferring cleavage-stage embryos on day 3 or blastocysts on day 5. RESULT(S): In singleton pregnancies, serum beta-hCG concentrations were 75 +/- 54 (mean +/- SD, n = 203) or 62 +/- 41 (n = 109) IU/mL after day 3 or day 5 transfers, respectively. In twin pregnancies, the beta-hCG concentrations were 162 +/- 105 (n = 52) or 109 +/- 55 (n = 49) after day 3 or day 5 transfers, respectively. The percentage increases in beta-hCG concentrations between the first and second measurements were similar in the two groups (day 3: 144 +/- 109, day 5: 142 +/- 63, not statistically significant). CONCLUSION(S): Initial beta-hCG concentrations in pregnancies resulting from day 5 transfers were lower than those from day 3 transfers when assessed at equivalent intervals from fertilization. This suggests that embryo development or implantation may be impaired by the additional 2 days in culture.
Subject(s)
Chorionic Gonadotropin, beta Subunit, Human/blood , Embryo Transfer/classification , Oocytes/cytology , Adult , Biomarkers/blood , Embryonic and Fetal Development/physiology , Female , Fertilization in Vitro/methods , Humans , Pregnancy , Pregnancy Outcome , Pregnancy, Multiple/statistics & numerical data , Reproducibility of Results , Retrospective Studies , Time Factors , Triplets , TwinsABSTRACT
OBJECTIVE: To evaluate whether different doses of exogenous LH affect IVF outcome. DESIGN: Retrospective analysis of two consecutive trials. SETTING: Infertility Unit of 1st Department of Obstetrics and Gynecology, University of Milan, Italy. PATIENTS: Two groups of 40 eumennorrheic patients matched for age and indications for in vitro fertilization. INTERVENTION: After suppression with a GnRH analogue, both groups received equal amounts of FSH in the first five days of stimulation; after this, the proportions of LH administered were doubled in one group because a different preparation was in use. MAIN OUTCOME MEASURES: The following observations were compared: number of scans (days to hCG), number of oocytes retrieved, fertilization rate, quality and number of embryos transferred, pregnancy and abortion rate. RESULTS: Doubling the amount of LH administered does not affect any outcome measure except the number of days of stimulation needed prior to hCG administration. CONCLUSIONS: No significant difference was seen in terms of number of oocytes, embryo number and quality, pregnancy and abortion rate. The only difference was the length of the stimulation phase.
