Subject(s)
Brain Diseases/drug therapy , Consciousness Disorders/drug therapy , Coronavirus Infections/therapy , Endarteritis/drug therapy , Glucocorticoids/administration & dosage , Methylprednisolone/administration & dosage , Pneumonia, Viral/therapy , Respiratory Distress Syndrome/therapy , Betacoronavirus , Brain Diseases/cerebrospinal fluid , Brain Diseases/diagnostic imaging , Brain Diseases/etiology , COVID-19 , Cerebral Angiography , Consciousness Disorders/etiology , Coronavirus Infections/complications , Endarteritis/cerebrospinal fluid , Endarteritis/diagnostic imaging , Endarteritis/etiology , Endothelium, Vascular/diagnostic imaging , Glasgow Coma Scale , Humans , Inflammation/diagnostic imaging , Inflammation/drug therapy , Magnetic Resonance Angiography , Magnetic Resonance Imaging , Oligoclonal Bands/cerebrospinal fluid , Pandemics , Pneumonia, Viral/complications , Recovery of Function , Respiration, Artificial , Respiratory Distress Syndrome/etiology , SARS-CoV-2Subject(s)
Betacoronavirus/genetics , Coronavirus Infections/diagnosis , Infarction/diagnosis , Intestinal Mucosa/metabolism , Intestine, Small/blood supply , Mesenteric Ischemia/diagnosis , Pneumonia, Viral/diagnosis , Betacoronavirus/metabolism , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques , Coronavirus Infections/complications , Coronavirus Infections/pathology , Endarteritis/etiology , Endarteritis/pathology , Fatal Outcome , Humans , Infarction/etiology , Infarction/pathology , Infarction/surgery , Intestinal Mucosa/virology , Intestine, Small/metabolism , Intestine, Small/surgery , Male , Mesenteric Ischemia/etiology , Mesenteric Ischemia/pathology , Mesenteric Ischemia/surgery , Middle Aged , Pandemics , Pneumonia, Viral/complications , Pneumonia, Viral/pathology , RNA, Messenger/metabolism , SARS-CoV-2 , Shock, Septic/etiology , Spike Glycoprotein, Coronavirus/genetics , Thrombosis/etiology , Thrombosis/pathology , Tomography, X-Ray ComputedABSTRACT
An 11-year-old boy presented with Staphylococcus aureus infective endarteritis and mycotic pseudoaneurysms within the context of a previously undiagnosed aortic coarctation. He had an urgent resection of the pseudoaneurysm and coarctation repair. Nuances to his initial diagnosis and key learning points related to the complication of pseudoaneurysm are discussed.
Subject(s)
Aneurysm, False/etiology , Aneurysm, Infected/etiology , Aortic Aneurysm, Thoracic/etiology , Aortic Coarctation/complications , Endarteritis/etiology , Staphylococcal Infections/etiology , Staphylococcus aureus/isolation & purification , Aneurysm, False/diagnosis , Aneurysm, False/microbiology , Aneurysm, Infected/diagnosis , Aneurysm, Infected/microbiology , Aortic Aneurysm, Thoracic/diagnosis , Aortic Aneurysm, Thoracic/microbiology , Aortic Coarctation/diagnosis , Child , Diagnosis, Differential , Endarteritis/diagnosis , Endarteritis/microbiology , Humans , Imaging, Three-Dimensional , Male , Staphylococcal Infections/diagnosis , Staphylococcal Infections/microbiology , Tomography, X-Ray ComputedABSTRACT
Isolated endarteritis of kidney transplants is increasingly recognized. Notably, microarray studies revealed absence of immunologic signatures of rejection in most isolated endarteritis biopsy samples. We investigated if isolated endarteritis responds to rejection treatment and affects kidney transplant survival. We retrospectively enrolled recipients of kidney transplant who underwent biopsies between 1999 and 2011 at seven American and Canadian centers. Exclusion criteria were recipients were blood group-incompatible or crossmatch-positive or had C4d-positive biopsy samples. After biopsy confirmation, patients were divided into three groups: isolated endarteritis (n=103), positive controls (type I acute T cell-mediated rejection with endarteritis; n=101), and negative controls (no diagnostic rejection; n=103). Primary end points were improved kidney function after rejection treatment and transplant failure. Mean decrease in serum creatinine from biopsy to 1 month after rejection treatment was 132.6 µmol/L (95% confidence interval [95% CI], 78.7 to 186.5) in patients with isolated endarteritis, 96.4 µmol/L (95% CI, 48.6 to 143.2) in positive controls (P=0.32), and 18.6 µmol/L (95% CI, 1.8 to 35.4) in untreated negative controls (P<0.001). Functional improvement after rejection treatment occurred in 80% of patients with isolated endarteritis and 81% of positive controls (P=0.72). Over the median 3.2-year follow-up period, kidney transplant survival rates were 79% in patients with isolated endarteritis, 79% in positive controls, and 91% in negative controls (P=0.01). In multivariate analysis, isolated endarteritis was associated with an adjusted 3.51-fold (95% CI, 1.16 to 10.67; P=0.03) risk for transplant failure. These data indicate that isolated endarteritis is an independent risk factor for kidney transplant failure.
Subject(s)
Endarteritis/etiology , Kidney Transplantation/adverse effects , Adult , Biopsy , Endarteritis/pathology , Endarteritis/therapy , Female , Graft Rejection/therapy , Graft Survival , Humans , Kidney/pathology , Male , Middle Aged , Retrospective StudiesSubject(s)
Ductus Arteriosus, Patent/complications , Endarteritis/etiology , Pseudomonas Infections/etiology , Pseudomonas aeruginosa , Pulmonary Artery , Ductus Arteriosus, Patent/diagnostic imaging , Echocardiography, Doppler, Color , Echocardiography, Transesophageal , Endarteritis/diagnostic imaging , Endocarditis, Bacterial/diagnostic imaging , Endocarditis, Bacterial/etiology , Female , Humans , Middle Aged , Pseudomonas Infections/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
The study included 107 patients with distal lesions of limb arteries treated with the use of thoracoscopic sympathectomy. The best results in the early postoperative period were obtained in patients with Raynaud's disease. Modifications introduced into the methods of its treatment permitted to retain effectiveness of sympathectomy till the late postoperative period in 90% of the patients. Surgery for obliterative endarteritis and atherosclerosis was viewed as a possibility to preserve the supporting function of the limb. This purpose was attained in 73.2 and 62.5% of the patients respectively in the early and in 62 and 25% in the late postoperative periods.
Subject(s)
Arteriosclerosis Obliterans/surgery , Endarteritis/surgery , Raynaud Disease/surgery , Sympathectomy , Thoracoscopy/methods , Arteriosclerosis Obliterans/diagnosis , Arteriosclerosis Obliterans/etiology , Arteriosclerosis Obliterans/physiopathology , Endarteritis/diagnosis , Endarteritis/etiology , Endarteritis/physiopathology , Extremities/blood supply , Ganglionectomy/adverse effects , Ganglionectomy/standards , Humans , Raynaud Disease/diagnosis , Raynaud Disease/physiopathology , Risk Factors , Secondary Prevention , Sympathectomy/adverse effects , Sympathectomy/methods , Sympathectomy/standards , Thoracic Nerves/surgery , Time , Transcutaneous Electric Nerve Stimulation , Treatment OutcomeSubject(s)
Ductus Arteriosus, Patent/diagnosis , Endarteritis/diagnosis , Respiratory Tract Infections/diagnosis , Contrast Media , Diagnosis, Differential , Ductus Arteriosus, Patent/complications , Ductus Arteriosus, Patent/therapy , Echocardiography, Doppler , Endarteritis/etiology , Endarteritis/therapy , Female , Humans , Middle Aged , Respiratory Tract Infections/etiology , Respiratory Tract Infections/therapy , Tomography, X-Ray ComputedABSTRACT
In the modern age of cancer therapy, advances in the multidisciplinary management of cancer have resulted in increased rates of survivorship. Radiation therapy (RT) toxicity must be tempered with the desire to achieve dose escalation to provide the best chance of long-term cure. This article is designed to acquaint emergency medicine physicians with common, expected, and potential acute and late complications of RT.
Subject(s)
Neoplasms/radiotherapy , Radiation Injuries/etiology , Emergency Service, Hospital , Endarteritis/diagnosis , Endarteritis/etiology , Endarteritis/physiopathology , Humans , Radiation Injuries/diagnosis , Radiation Injuries/physiopathology , Radiation Pneumonitis/diagnosis , Radiation Pneumonitis/etiology , Radiation Pneumonitis/physiopathology , Radiotherapy/adverse effectsABSTRACT
The experience of examination and treatment of about 3000 patients having chronic arterial ischemia of extremities allowed to determine that such a clinical presentation appears as a result of functional organic diseases of arteries of extremities: arterial vasoconstriction and obliterating disease of arteries (obliterating atherosclerosis, obliterating endoarteritis, diabetic angiopathy). Chronic ischemia of extremities develops from arterial vasoconstriction of central genesis and then obliterating disease of arteries joins the process. The paper is devoted to the first phase of development of chronic arterial ischemia of extremities: vertebragenous angiospastic disease of arteries of extremities and its treatment for patients of middle and old age.
Subject(s)
Arteriosclerosis Obliterans , Diabetic Angiopathies , Endarteritis , Ischemia , Leg/blood supply , Adult , Aged , Aged, 80 and over , Arteriosclerosis Obliterans/complications , Arteriosclerosis Obliterans/etiology , Arteriosclerosis Obliterans/physiopathology , Chronic Disease , Diabetic Angiopathies/complications , Diabetic Angiopathies/physiopathology , Endarteritis/complications , Endarteritis/etiology , Endarteritis/physiopathology , Female , Humans , Ischemia/diagnosis , Ischemia/etiology , Ischemia/surgery , Ischemia/therapy , Laser Therapy , Magnetic Resonance Imaging , Male , Middle Aged , VasoconstrictionABSTRACT
A 49-year-old man without heart murmur was admitted with fever because of bacteremia following a tooth extraction. Antibiotics rapidly alleviated the fever; however, a small nodule in the pulmonary artery was identified on computed tomography (CT). When the patient experienced chest discomfort with fever, CT demonstrated the absence of the nodule and the appearance of an abnormal lung opacity, and echocardiography showed turbulent retrograde flow in the pulmonary artery. We had the rare opportunity to follow a case of pulmonary bacterial endarteritis and subsequent pulmonary embolism with clinically silent patent ductus arteriosus (PDA) that was confirmed by 3-dimensional CT.
Subject(s)
Ductus Arteriosus, Patent/complications , Endarteritis/etiology , Pulmonary Embolism/etiology , Ductus Arteriosus, Patent/diagnosis , Ductus Arteriosus, Patent/pathology , Endarteritis/diagnosis , Endarteritis/pathology , Humans , Imaging, Three-Dimensional , Male , Middle Aged , Pulmonary Artery/pathology , Pulmonary Embolism/diagnosis , Pulmonary Embolism/pathology , Tomography, X-Ray ComputedABSTRACT
Pulmonary arterial endarteritis is a rare event even in patients with congenital heart disease. In this paper, the authors report two cases of pulmonary endarteritis diagnosed at autopsy. The first was a 3-month-old male infant with absence of congenital heart defect (who had had neonatal sepsis). This patient presented with pneumonia and succumbed within 36 hours of hospital stay despite appropriate antimicrobial therapy and supportive management. The second patient was a 13-month-old male child with previously undiagnosed tetralogy of Fallot who had clinical presentation of acute meningitis with convulsions and succumbed within 12 hours of hospital stay despite adequate treatment. The main autopsy findings were chronic arteritis of the pulmonary trunk and right pulmonary artery in the former and rupture of the pulmonary trunk in the latter.
Subject(s)
Endarteritis/complications , Endarteritis/etiology , Meningitis/complications , Pulmonary Artery/pathology , Sepsis/complications , Tetralogy of Fallot/complications , Acute Disease , Endarteritis/pathology , Fatal Outcome , Humans , Infant , Infant, Newborn , Male , Seizures/etiologyABSTRACT
The majority of older patients with uncorrected coarctation of the aorta die before the age of 50 years from many complications. We report our experience in treating this type of congenital malformation in a 40-year-old man who developed aortic endarteritis as a rare complication.
Subject(s)
Aortic Coarctation/complications , Endarteritis/etiology , Adult , Aorta, Thoracic , Aortic Coarctation/drug therapy , Aortic Coarctation/surgery , Echocardiography, Transesophageal , Endarteritis/drug therapy , Endarteritis/surgery , Humans , Male , Tomography, X-Ray ComputedABSTRACT
This is a case report of a femoral artery infection with fatal outcome after using a percutaneous suture mediated closure device: A 77-year old patient underwent diagnostic angiography of his thoracic and abdominal aortic aneurysm, the puncture site was closed with the Perclose system. He developed a staphylococcal femoral artery infection with groin abscess, requiring surgical intervention with debridement and removal of the Perclose suture. After stent graft exclusion of the thoracic and abdominal aortic aneurysm a staphylococcal sepsis occurred and the patient died of aneurysm rupture months later despite long term antibiotic therapy. Since the use of the Perclose device carries an increased risk of femoral artery infection with septic endarteritis and bacteremia, it should not be used in routine diagnostic angiography.
Subject(s)
Endarteritis/etiology , Endarteritis/pathology , Femoral Artery/pathology , Staphylococcal Infections/etiology , Staphylococcal Infections/pathology , Sutures/adverse effects , Aged , Angiography/adverse effects , Angiography/methods , Fatal Outcome , Humans , Male , Punctures/adverse effects , Wounds, Penetrating/complications , Wounds, Penetrating/therapyABSTRACT
The authors describe a case of pulmonary endarteritis and subsequent embolization to the lungs as a complication of a patent ductus arteriosus (PDA). Although 2-dimensional echocardiography has been shown to be of great value in the diagnosis of patients with infective endocarditis, echocardiographic detection of vegetation within the pulmonary artery and subsequent embolization to the lung is extremely rare and, to our knowledge, has been previously reported only in a few cases. In brief, our case not only shows the importance of echocardiography in making this rare diagnosis but also emphasizes the role of echocardiography as an effective means of following up such a case.