Subject(s)
Epiglottis/microbiology , Epiglottitis/diagnosis , Mycobacterium tuberculosis , Tuberculosis, Laryngeal/diagnosis , Aged, 80 and over , Diagnosis, Differential , Epiglottitis/microbiology , Humans , Laryngeal Neoplasms/diagnosis , Male , Medical Illustration , Tuberculosis, Laryngeal/microbiologyABSTRACT
Histoplasmosis is an endemic disease mainly occurring in North America and is rare in China. Confirmation of histoplasmosis should be based on a compatible clinical scenario and a positive culture or histopathology. However, there are still many cases that are misdiagnosed or missed, especially in individuals from non-endemic areas. In recent years, metagenomic next-generation sequencing (mNGS) has led to the accurate and timely diagnosis of some rare and complicated infectious diseases. We describe the case of a 27-year-old Chinese man who had chronic progressive pulmonary lesions without any symptoms for more than 1year, until the lesions reached the epiglottis and led to progressive pharyngeal pain. There were no positive results from bronchoalveolar lavage fluid (BALF) and epiglottis tissue cultures, or from epiglottis and lung pathological examinations, but mNGS was able to identify Histoplasma capsulatum in the epiglottis tissues and BALF as the cause of the lesions. The patient was treated successfully with itraconazole.
Subject(s)
Epiglottis/microbiology , Histoplasma/isolation & purification , Histoplasmosis/microbiology , Lung/microbiology , Adult , Asian People , Bronchoalveolar Lavage Fluid , Epiglottis/pathology , High-Throughput Nucleotide Sequencing , Humans , Itraconazole/therapeutic use , Lung/pathology , Male , MetagenomicsSubject(s)
Epiglottis/pathology , Larynx/pathology , Syphilis , Aged , Epiglottis/microbiology , Humans , Larynx/microbiology , MaleSubject(s)
Central Nervous System Fungal Infections/physiopathology , Histoplasmosis/physiopathology , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Central Nervous System Fungal Infections/drug therapy , Central Nervous System Fungal Infections/pathology , Diagnostic Errors , Epiglottis/microbiology , Epiglottis/pathology , Female , Granuloma/microbiology , Granuloma/pathology , Histoplasmosis/drug therapy , Histoplasmosis/pathology , Humans , Middle Aged , Recurrence , Spinal Cord/microbiology , Spinal Cord/pathology , Tuberculosis, Meningeal/pathology , Tuberculosis, Meningeal/physiopathologyABSTRACT
The case of a 29-year-old patient with active laryngeal tuberculosis predominantly involving the epiglottis, without pulmonary disease, is presented. The predominant symptoms are dysphagia, odynophagia, and hoarseness. Laryngeal carcinoma, which shares almost the same symptoms and signs, should be ruled out immediately. Laryngeal tuberculosis is discussed with a brief literature review.
Subject(s)
Antitubercular Agents/therapeutic use , Epiglottis/microbiology , Tuberculosis, Laryngeal/diagnosis , Adult , Humans , Male , Mycobacterium tuberculosis , Tuberculosis, Laryngeal/drug therapy , Tuberculosis, Laryngeal/microbiologySubject(s)
Candidiasis/diagnosis , Candidiasis/drug therapy , Emergencies , Epiglottis/microbiology , Epiglottitis/diagnosis , Epiglottitis/drug therapy , Immunocompromised Host , Aged , Antifungal Agents/therapeutic use , Candidiasis/etiology , Diagnosis, Differential , Epiglottitis/etiology , Epiglottitis/microbiology , Fluconazole/therapeutic use , Humans , Male , Middle Aged , Treatment OutcomeABSTRACT
We present a 40-year-old woman with pulmonary tuberculosis and epiglottic involvement that was initially misdiagnosed as laryngeal carcinoma. The differential diagnosis and management of epiglottic tuberculosis is reviewed and discussed. Although epiglottic tuberculosis is rare, otorhinolaryngologists should keep in mind the possibility of tuberculosis in the differential diagnosis of laryngeal tumors. Constitutional symptoms and mild chest symptoms should not always be attributed to carcinoma and smoking.
Subject(s)
Antitubercular Agents/therapeutic use , Epiglottis/microbiology , Tuberculosis, Laryngeal/diagnosis , Tuberculosis, Laryngeal/drug therapy , Adult , Diagnosis, Differential , Female , HumansABSTRACT
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is emerging as an important pathogen. However, MRSA rarely causes epiglottitis. We report an adult with epiglottitis due to a CA-MRSA isolate of the USA300 lineage with Panton-Valentine leukocidin. Maintaining vigilance for CA-MRSA as a cause of an expanding spectrum of severe infections is warranted.
Subject(s)
Epiglottis/microbiology , Methicillin Resistance , Staphylococcal Infections/complications , Staphylococcal Infections/diagnosis , Staphylococcus aureus/isolation & purification , Adult , Humans , Male , Staphylococcal Infections/therapySubject(s)
Epiglottitis/microbiology , Streptococcal Infections/surgery , Streptococcus pyogenes , Tonsillitis/complications , Adult , Anti-Bacterial Agents/administration & dosage , Cefuroxime/administration & dosage , Clindamycin/administration & dosage , Drug Therapy, Combination , Epiglottis/microbiology , Epiglottitis/etiology , Female , Humans , Recurrence , Tongue/microbiology , Tonsillectomy , Tonsillitis/microbiology , Tonsillitis/surgeryABSTRACT
An important arousal of tuberculosis has been observed in the last years, together with a change in it's clinical patterns, specially the extrapulmonar form, among wich is this laryngeal tuberculosis. This two facts and the marked polymorphism and mimetism proper of this condition may suggest that the Mycobacterium tuberculosis should be included in the differential diagnosis of any atypical lesion of the larynx, in order to obtain an earlier diagnosis excluding carcinoma and instaurate a chimotherapic protocol for minimizing or even avoiding any sequelae. Tuberculous epiglotittis is one of these atypical and unusual forms. The authors report a case of a 67 year-old male and provide a discussion on the diagnostic problems of this condition.
Subject(s)
Epiglottis/microbiology , Tuberculosis, Laryngeal/microbiology , Aged , Antitubercular Agents/therapeutic use , Epiglottis/diagnostic imaging , Humans , Laryngoscopy , Male , Mycobacterium tuberculosis/isolation & purification , Neck , Radiography, Thoracic , Tomography, X-Ray Computed , Tuberculosis, Laryngeal/diagnosis , Tuberculosis, Laryngeal/drug therapyABSTRACT
Estamos asistiendo en los últimos años a un resurgir de la tuberculosis, con especial mención a las formas extrapulmonares, entre las que se encuentra la tuberculosis laríngea, a la vez que a un cambio en los patrones típicos de presentación recogidos históricamente en la literatura médica. Estos dos hechos, unidos al conocido polimorfismo y mimetismo de esta enfermedad, hacen que sea importante pensar en el Mycobacterium tuberculosis como el causante de lesiones atípicas objetivadas en la laringe del paciente, para lograr realizar un diagnóstico precoz de la misma que, por un lado, descarte la existencia de carcinoma, y, por otro, permita la instauración inmediata de un protocolo quimioterápico antituberculoso que impida o minimice las posibles secuelas de la misma. La epiglotitis tuberculosa es una de estas formas atípicas e infrecuentes de presentación. Los autores presentan un caso de un varón de 67 años y realizan una discusión de los problemas diagnósticos que presenta esta entidad
An important arousal of tuberculosis has been observed in the last years, together with a change in it's clinical patterns, specially the extrapulmonar form, among wich is this laryngeal tuberculosis. This two facts and the marked polymorphism and mimetism proper of this condition may suggest that the Mycobacterium tuberculosis should be included in the differential diagnosis of any atypical lesion of the larynx, in order to obtain an earlier diagnosis excluding carcinoma and instaurate a chimotherapic protocol for minimizing or even avoiding any sequelae.Tuberculous epiglotittis is one of these atypical and unusual forms. The authors report a case of a 67 year-old male and provide a discussion on the diagnostic problems of this condition
Subject(s)
Male , Aged , Humans , Epiglottis/microbiology , Mycobacterium tuberculosis/isolation & purification , Tuberculosis, Laryngeal/microbiology , Antitubercular Agents/therapeutic use , Epiglottis , Laryngoscopy , Radiography, Thoracic , Tomography, X-Ray Computed , Tuberculosis, Laryngeal/diagnosis , Tuberculosis, Laryngeal/drug therapySubject(s)
Epiglottis/microbiology , Histoplasmosis/epidemiology , Aged , Endemic Diseases , Humans , MaleSubject(s)
Mycobacterium/isolation & purification , Tuberculosis, Laryngeal , Acetylcysteine/therapeutic use , Adult , Antitubercular Agents/therapeutic use , Epiglottis/microbiology , Epiglottis/pathology , Ethambutol/therapeutic use , Female , Granuloma, Laryngeal/pathology , Humans , Isoniazid/therapeutic use , Rifampin/therapeutic use , Tuberculosis, Laryngeal/drug therapy , Tuberculosis, Laryngeal/pathologyABSTRACT
Invasive fungal infections are associated with high morbidity and mortality in immunocompromised patients. We describe an unusual case of concomitant invasive candidiasis and zygomycosis of the tongue and epiglottis that occurred in a young patient with neutropenia during chemotherapy for acute myelogenous leukemia and was successfully treated medically.