ABSTRACT
Este es un análisis prospectivo endocrinológico de la respuesta al ejercicio físico agudo/crónico combinado con el estrés emocional de una población militar de 14 aspirantes a ingresar al Batallón de Fusileros Paracaidistas del Ejército Nacional Mexicano, con patrón de sueño, conducta sexual y dieta controlados. En cada individuo se determinó hormona estimulante del folículo, hormona luteinizante, testosterona, estradiol, prolactina y progesterona plasmáticos. Estas hormonas se relacionaron con elementos del semen. El estudio se dividió en cuatro etapas: fase I: control; fase II: 4.5 horas de ejercicio de calentamiento + 10 km de caminata-trote al día durante seis semanas y primer salto en paracaídas; fase III: 2 horas de ejercicio de calentamiento + 5 km de trote diariamente por seis semanas + salto en paracaídas; y fase IV: similar a la fase III en actividades físicas pero con una duración de doce semanas. De ese análisis la respuesta más inesperada fue una elevación del estradiol sin cambios en la testosterona, hormona luteinizante, hormona estimulante del folículo ni prolactina en la fase II; mientras que en las fases III y IV se detectó incremento de la testosterona a la elevación de la hormona luteinizante y prolactina. Estos cambios hormonales no originaron efectos deletéreos en el semen. El hallazgo de la respuesta estrógenica podría se un índice de utilidad para valorar la respuesta fisiológica/clínica al estrés físico emocional en el varón
Subject(s)
Humans , Male , Adult , Semen/physiology , Exercise/physiology , Exercise/psychology , Estrogens, Conjugated (USP)/analysis , Estrogens, Conjugated (USP)/metabolism , Stress, Psychological/physiopathology , Stress, Psychological/psychologyABSTRACT
The relation conjugated/unconjugated estrogens associated with reproductive processes has brought about the interest to study the biological role and regulation of the estrogen sulfotransferase and estrogen sulfatase which participate in the formation and hydrolysis of estrogen 3-sulfates, respectively. In this paper, both activities were measured through the reciprocal conversion of 3H-estrone sulfate and 3H-unconjugated estrogen during in vitro incubation with implantation sites (SI) and non-implanted sites (SNI) from the rat uterus, during the process of embryo implantation. Contrasting enzyme activities were found in these tissues. While sulfotransferase activity was higher in SI than in SNI (0.205 vs 0.144 pmol of E1S formed/mg protein/h, the inverse was found for the sulfatase (1.470 vs 1.977 pmol of E1 formed/mg protein/h). These results indicate the presence of both enzymes in the rat uterus and suggest the existence of a mechanism in SI that locally regulate the concentration of free and sulfoconjugated estrogens in which these enzymes participate.
Subject(s)
Embryo Implantation/physiology , Sulfatases/physiology , Sulfotransferases/physiology , Uterus/enzymology , Animals , Estrogens/metabolism , Estrogens, Conjugated (USP)/metabolism , Estrone/analogs & derivatives , Estrone/metabolism , Female , Hydrolysis , In Vitro Techniques , Pregnancy , Rats , Sulfates/metabolism , Uterus/metabolismABSTRACT
Estrogen conjugates are generally considered as inactivated forms devoid of any estrogenic activity. In some therapies, such as that used during menopause, high dose of estrogen sulfate are currently used as non estrogenic agent. However, precaution should be taken since a considerable amount of this conjugate can be converted into estradiol-17 beta (E2), the most biologically active hormone. In vitro, estrone sulfate (E1S), is converted into estrone (E1) and E2 by the action of estrogen sulfatase and 17 beta-oxydoreductase enzymes. Since the half life E1S in plasma is much higher than that of other estrogens, this conjugate could provide a continuous supply of E2 to estrogen target cells, which may be biologically important. It is the purpose of this review to point out the important role of estrogen sulfates in breast carcinoma.