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1.
PLoS One ; 17(1): e0261318, 2022.
Article in English | MEDLINE | ID: mdl-34986191

ABSTRACT

Assistive exoskeletons can reduce the metabolic cost of walking, and recent advances in exoskeleton device design and control have resulted in large metabolic savings. Most exoskeleton devices provide assistance at either the ankle or hip. Exoskeletons that assist multiple joints have the potential to provide greater metabolic savings, but can require many actuators and complicated controllers, making it difficult to design effective assistance. Coupled assistance, when two or more joints are assisted using one actuator or control signal, could reduce control dimensionality while retaining metabolic benefits. However, it is unknown which combinations of assisted joints are most promising and if there are negative consequences associated with coupled assistance. Since designing assistance with human experiments is expensive and time-consuming, we used musculoskeletal simulation to evaluate metabolic savings from multi-joint assistance and identify promising joint combinations. We generated 2D muscle-driven simulations of walking while simultaneously optimizing control strategies for simulated lower-limb exoskeleton assistive devices to minimize metabolic cost. Each device provided assistance either at a single joint or at multiple joints using massless, ideal actuators. To assess if control could be simplified for multi-joint exoskeletons, we simulated different control strategies in which the torque provided at each joint was either controlled independently or coupled between joints. We compared the predicted optimal torque profiles and changes in muscle and total metabolic power consumption across the single joint and multi-joint assistance strategies. We found multi-joint devices-whether independent or coupled-provided 50% greater metabolic savings than single joint devices. The coupled multi-joint devices were able to achieve most of the metabolic savings produced by independently-controlled multi-joint devices. Our results indicate that device designers could simplify multi-joint exoskeleton designs by reducing the number of torque control parameters through coupling, while still maintaining large reductions in metabolic cost.


Subject(s)
Exoskeleton Device/economics , Exoskeleton Device/trends , Adult , Animals , Ankle/physiology , Ankle Joint/physiology , Biomechanical Phenomena/physiology , Computer Simulation , Electromyography , Energy Metabolism/physiology , Humans , Male , Muscle, Skeletal/physiology , Self-Help Devices , Walking/physiology
2.
Proc Inst Mech Eng H ; 235(5): 530-545, 2021 May.
Article in English | MEDLINE | ID: mdl-33588634

ABSTRACT

In this work, the design, modeling, and development of a low-cost lower limb exoskeleton (LLES) system are presented for paediatric rehabilitation (age: 8-12 years, mass: 25-40 kg, height: 115-125 cm). The exoskeleton system, having three degrees-of-freedom (DOFs) for each limb, is designed in the SolidWorks software. A wheel support module is introduced in the design to ensure the user's stability and safety. The finite element analysis of the hip joint connector along with the wheel support module is realized for maximum loading conditions. The holding torque capacity of exoskeleton joints is estimated using an affordable spring-based experimental setup. A working prototype of the LLES is developed with holding torque rated actuators. Thereafter, the dynamic analysis for the human-exoskeleton coupled system is carried out using the Euler-Lagrange principle and SimMechanics model. The simulation results of estimating joint actuator torques are obtained for two paraplegic subjects (Case I: 10 years age, 30 kg mass, 120 cm height and Case II: 12 years age, 40 kg mass, 125 cm height). The details of input parameters such as body mass, link lengths, joint angles, and contact forces are discussed. The simulation results of dynamic analysis have shown the potential of estimating the torques of joint actuators for the developed prototype during motion assistance and gait rehabilitation.


Subject(s)
Equipment Design , Exoskeleton Device/economics , Gait , Leg , Pediatrics , Rehabilitation , Biomechanical Phenomena , Child , Equipment Design/economics , Hip Joint , Humans , Male , Torque
3.
BMC Health Serv Res ; 20(1): 955, 2020 Oct 15.
Article in English | MEDLINE | ID: mdl-33059683

ABSTRACT

BACKGROUND: Falls may lead to hip fractures, which have a detrimental effect on the prognosis of patients as well as a considerable impact on healthcare expenditures. Since a secondary hip fracture (SHF) may lead to even higher costs than primary fractures, the development of innovative services is crucial to limit falls and curb costs in high-risk patients. An early economic evaluation assessed which patients with a second hip fracture could benefit most from an exoskeleton preventing falls and whether its development is feasible. METHODS: The life-course of hip fractured patients presenting with dementia or cardiovascular diseases was simulated using a Markov model relying on the United Kingdom administrative data and complemented by published literature. A group of experts provided the exoskeleton parameters. Secondary analyses included a threshold analysis to identify the exoskeleton requirements (e.g. minimum impact of the exoskeleton on patients' quality of life) leading to a reimbursable incremental cost-effectiveness ratio. Similarly, the uncertainty around these requirements was modelled by varying their standard errors and represented alongside population Expected Value of Perfect Information (EVPI). RESULTS: Our base-case found the exoskeleton cost-effective when providing a statistically significant reduction in SHF risk. The secondary analyses identified 286 cost-effective combinations of the exoskeleton requirements. The uncertainty around these requirements was explored producing further 22,880 scenarios, which showed that this significant reduction in SHF risk was not necessary to support the exoskeleton adoption in clinical practice. Conversely, a significant improvement in women quality of life was crucial to obtain an acceptable population EVPI regardless of the cost of the exoskeleton. CONCLUSIONS: Our study identified the exoskeleton requisites to be cost-effective and the value of future research. Decision-makers could use our analyses to assess not only whether the exoskeleton could be cost-effective but also how much further research and development of the exoskeleton is worth to be pursued.


Subject(s)
Exoskeleton Device/economics , Hip Fractures/prevention & control , Aged , Aged, 80 and over , Cost-Benefit Analysis , Female , Humans , Male , Markov Chains , Quality of Life , Uncertainty , United Kingdom
4.
J Neuroeng Rehabil ; 17(1): 4, 2020 01 10.
Article in English | MEDLINE | ID: mdl-31924224

ABSTRACT

BACKGROUND: We know little about the budget impact of integrating robotic exoskeleton over-ground training into therapy services for locomotor training. The purpose of this study was to estimate the budget impact of adding robotic exoskeleton over-ground training to existing locomotor training strategies in the rehabilitation of people with spinal cord injury. METHODS: A Budget Impact Analysis (BIA) was conducted using data provided by four Spinal Cord Injury (SCI) Model Systems rehabilitation hospitals. Hospitals provided estimates of therapy utilization and costs about people with spinal cord injury who participated in locomotor training in the calendar year 2017. Interventions were standard of care walking training including body-weight supported treadmill training, overground training, stationary robotic systems (i.e., treadmill-based robotic gait orthoses), and overground robotic exoskeleton training. The main outcome measures included device costs, training costs for personnel to use the device, human capital costs of locomotor training, device demand, and the number of training sessions per person with SCI. RESULTS: Robotic exoskeletons for over-ground training decreased hospital costs associated with delivering locomotor training in the base case analysis. This analysis assumed no difference in intervention effectiveness across locomotor training strategies. Providing robotic exoskeleton overground training for 10% of locomotor training sessions over the course of the year (range 226-397 sessions) results in decreased annual locomotor training costs (i.e., net savings) between $1114 to $4784 per annum. The base case shows small savings that are sensitive to parameters of the BIA model which were tested in one-way sensitivity analyses, scenarios analyses, and probability sensitivity analyses. The base case scenario was more sensitive to clinical utilization parameters (e.g., how often devices sit idle and the substitution of high cost training) than device-specific parameters (e.g., robotic exoskeleton device cost or device life). Probabilistic sensitivity analysis simultaneously considered human capital cost, device cost, and locomotor device substitution. With probabilistic sensitivity analysis, the introduction of a robotic exoskeleton only remained cost saving for one facility. CONCLUSIONS: Providing robotic exoskeleton for over-ground training was associated with lower costs for the locomotor training of people with SCI in the base case analyses. The analysis was sensitive to parameter assumptions.


Subject(s)
Exoskeleton Device/economics , Neurological Rehabilitation/economics , Neurological Rehabilitation/instrumentation , Spinal Cord Injuries/rehabilitation , Adult , Female , Hospital Costs , Humans , Male , Middle Aged , Models, Economic
5.
IEEE Trans Neural Syst Rehabil Eng ; 26(12): 2376-2386, 2018 12.
Article in English | MEDLINE | ID: mdl-30387735

ABSTRACT

Improvement in hand function to promote functional recovery is one of the major goals of stroke rehabilitation. This paper introduces a newly developed exoskeleton for hand rehabilitation with a user-centered design concept, which integrates the requirements of practical use, mechanical structure, and control system. The paper also evaluated the function with two prototypes in a local hospital. Results of functional evaluation showed that significant improvements were found in ARAT (P = 0.014), WMFT (P = 0.020), and FMA_WH (P = 0.021). Increase in the mean values of FMA_SE was observed but without significant difference (P = 0.071). The improvement in ARAT score reflects the motor recovery in hand and finger functions. The increased FMA scores suggest there is a motor improvement in the whole upper limb, and especially in the hand after the training. The product met patients' requirements and has practical significance. It is portable, cost-effective, easy to use and supports multiple control modes to adapt to different rehabilitation phases.


Subject(s)
Exoskeleton Device , Hand , Stroke Rehabilitation/instrumentation , Aged , Algorithms , Biomechanical Phenomena , Cost-Benefit Analysis , Electromyography , Equipment Design , Exoskeleton Device/economics , Female , Fingers , Hand Strength , Humans , Male , Middle Aged , Pilot Projects , Psychomotor Performance , Range of Motion, Articular , Recovery of Function , Stroke Rehabilitation/economics , Upper Extremity
6.
Acta Neurochir Suppl ; 124: 211-215, 2017.
Article in English | MEDLINE | ID: mdl-28120076

ABSTRACT

The ReAbility Project is a solution that provides an alternative to wheelchair mobility for people with serious disabilities of the lower limbs, such as paraplegics, allowing them to stand and walk once again. This solution is achieved by utilizing an instrument called an "exoskeleton".The ReAbility device is a robotic-assisted system designed to improve the quality of life of people with a movement disability and/or reduced movement; it is meant both for daily domestic use and for rehabilitation therapy in hospitals and rehabilitation centers.The principal characteristics of the device are its modularity, manageability, and wearability for the patient, who is actively involved and has full control of all the movement functions. Its light weight (16 kg) renders it easy to wear for the patient and competitive on the market. From an esthetic perspective it can be worn under clothes, with obvious and important psychological and social advantages. Its cost is also well contained.With the use of this device, there is also a very real positive effect on healthcare costs.


Subject(s)
Exoskeleton Device , Paraplegia/rehabilitation , Spinal Cord Injuries/rehabilitation , Exoskeleton Device/economics , Health Care Costs , Humans
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