ABSTRACT
OBJECTIVE: The aim of this review is to describe the "hot points" of current clinical governance for oral HPV comprising the use of new diagnostic molecular procedures, namely, Pyrosequencing and Next Generation Sequencing. MATERIALS AND METHODS: The data on oral HPV was collected through two levels of research. First for all, we used the canonical medical search engines, PubMed, and Medline, followed by the study of current commercial tools for HPV diagnosis, particularly within commercial companies involved in the molecular procedures for HPV detecting and genotyping. RESULTS: Different medical procedures are now described and used throughout the world in HPV diagnosis and treatment. However, the laboratory methods are often validated and used for genital infections, and, in these cases, data are missing in the literature as regards the clinical approach for oral lesions. CONCLUSIONS: Dental care units are often the front line for a clinical evaluation of a possible HPV lesion in the oral cavity, which means that correct clinical governance could avoid a viral neoplastic progression of this disease with great advantages for the patient. In this case, the problem is due to the difficulty in lesion recognition but also and more especially the absence of correct laboratory diagnosis and subsequent treatment in the clinical course.
Subject(s)
Mouth Diseases/diagnosis , Mouth Diseases/therapy , Papillomavirus Infections/diagnosis , Papillomavirus Infections/therapy , Carcinoma, Verrucous/diagnosis , Carcinoma, Verrucous/therapy , Carcinoma, Verrucous/virology , Cryosurgery , Focal Epithelial Hyperplasia/diagnosis , Focal Epithelial Hyperplasia/therapy , Focal Epithelial Hyperplasia/virology , Humans , Laser Therapy , Leukoplakia, Oral/diagnosis , Leukoplakia, Oral/therapy , Leukoplakia, Oral/virology , Lichen Planus, Oral/diagnosis , Lichen Planus, Oral/therapy , Lichen Planus, Oral/virology , Mouth Diseases/virology , Mouth Neoplasms/diagnosis , Mouth Neoplasms/therapy , Mouth Neoplasms/virology , Papilloma/diagnosis , Papilloma/therapy , Papilloma/virology , Papillomaviridae/genetics , Papillomavirus Infections/virology , Photochemotherapy , Squamous Cell Carcinoma of Head and Neck/diagnosis , Squamous Cell Carcinoma of Head and Neck/therapy , Squamous Cell Carcinoma of Head and Neck/virology , Warts/diagnosis , Warts/therapy , Warts/virologyABSTRACT
Focal epithelial hyperplasia (FEH) or Heck's disease is a rare, benign and asymptomatic mucosal proliferation associated with human papillomavirus (HPV) infection, mainly with genotypes 13 and 32. We report a florid case of FEH in an 11-year-old Haitian girl with systemic lupus erythematosus receiving immunosuppressive therapy. Cryotherapy was previously performed on numerous occasions with no results. We decided to prescribe a non-invasive and more comfortable treatment. A combination of topical retinoid and imiquimod cream was well tolerated and led to an important improvement. The evidence of infection by HPV-16 detected by polymerase chain reaction (PCR) technique, prompted us to prescribe the quadrivalent HPV vaccine (types 6, 11,16 and 18). Subsequent PCR sequencing with generic primers GP5-GP6 and further BLAST comparative analysis confirmed that genomic viral sequence in our case truly corresponded with HPV-32. This molecular misdiagnosis can be explained by the similarity between genomic sequences of both HPV-16 and -32 genotypes. At the 1-year follow up, we observed total clinical improvement and no recurrences of the disease. Complete healing in this case may correspond to a potential action of topical retinoid, imiquimod and the cross-protection mechanism of the quadrivalent HPV vaccine.
Subject(s)
Focal Epithelial Hyperplasia/diagnosis , Human papillomavirus 16 , Papillomaviridae , Papillomavirus Infections/diagnosis , Papillomavirus Infections/therapy , Adjuvants, Immunologic/administration & dosage , Aminoquinolines/administration & dosage , Child , Combined Modality Therapy , Diagnostic Errors , Female , Focal Epithelial Hyperplasia/therapy , Focal Epithelial Hyperplasia/virology , Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18/administration & dosage , Human papillomavirus 16/genetics , Human papillomavirus 16/isolation & purification , Humans , Imiquimod , Papillomaviridae/classification , Papillomaviridae/genetics , Papillomaviridae/isolation & purification , Papillomavirus Infections/virology , Retinoids/administration & dosageABSTRACT
Focal epithelial hyperplasia or Heck's disease is an infrequent asymptomatic condition caused by human papillomavirus types 13 or 32 affecting the mucous membrane of the mouth and is commonly seen in young individuals. Firstly, it was described in Indians and Eskimos, but it exists in various populations. We present three cases of Heck's disease in an Afghan immigrant family group living in Iran that seem to have familial predominance. The disease was identified as oral focal epithelial hyperplasia on the basis of histopathologic and clinical findings. The lesions were reduced significantly after 4 months of good oral hygiene. Dentists should be familiar with the clinical manifestations of these types of lesions that affect the oral cavity. In fact, histopathologic assessment and clinical observation are necessary to establish the diagnosis.
Subject(s)
Focal Epithelial Hyperplasia/pathology , Mouth Mucosa/pathology , Papillomavirus Infections/pathology , Adult , Biopsy , Child , Child, Preschool , Female , Focal Epithelial Hyperplasia/therapy , Focal Epithelial Hyperplasia/virology , Humans , Male , Mouth Mucosa/virology , Oral Hygiene , Papillomavirus Infections/therapy , Papillomavirus Infections/virology , Remission Induction , Time Factors , Treatment OutcomeABSTRACT
La hiperplasia epitelial focal (HEF) o enfermedad de Heck es una patolog¡a poco frecuente de la mucosa oral, caracterizada por una proliferaci¢n benigna del epitelio debida a la infecci¢n por el papilomavirus humano (PVH) tipos 13 y 32. El nombre enfermedad de Heck deriva del nombre del mdico que evalu¢ al primer paciente, en Mxico, en 1961. Sin embargo, una revisi¢n de la literatura latinoamericana revela publicaciones previas realizadas por Estrada, en 1956, quien observ¢ esta entidad en indios colombianos. Algunos a¤os despus, Soneira y Fonseca realizaron la primera descripci¢n completa de la enfermedad, y se¤alaron sus caracter¡sticas cl¡nicas e histol¢gicas y, adem s, sugirieron el posible origen viral. Finalmente, en 1965, Archard y col. la denominaron HEF, aunque en la actualidad se sugiere utilizar el nombre de hiperplasia multifocal del epitelio, que describe mejor las caracter¡sticas cl¡nicas y microsc¢picas de la enfermedad. La HEF, aunque.
The focal epithelial hyperplasia (HEF) or Heck's disease is a rare disease of the oral mucosa, characterized by benign epithelial proliferation due to infection with human papillomavirus (HPV) ttypes 13 and 32. The disease name derives Heck the name of the doctor who evaluated the first patient in Mexico in 1961. However, a review of Latin American literature reveals previous publications by Estrada, in 1956, who observed this entity in Colombian Indians. Some years later, Soneira and Fonseca made the first complete description of the disease, noting their clinical and histological features and also suggested the possible viral origin. Finally in 1965, Archard et al. HEF called it, although at present it is suggested to use the name multifocal epithelial hyperplasia, which best describes the clinical and microscopic features of the disease. The HEF is presented with a clear predominance of Americans, Eskimos and Indians some communities in South Africa, although isolated cases in other ethnic groups. In South America it is more common in the Amazon basin of Peru, Venezuela, Colombia, Bolivia, Brazil and Paraguay.
Subject(s)
Focal Epithelial Hyperplasia , Focal Epithelial Hyperplasia/diagnosis , Focal Epithelial Hyperplasia/etiology , Focal Epithelial Hyperplasia/pathology , Focal Epithelial Hyperplasia/therapyABSTRACT
La hiperplasia epitelial multifocal es una enfermedad benigna que se caracteriza por la presencia de múltiples pápulas en la mucosa de la cavidad bucal, asociada con el virus del papiloma humano 13 y 32. En el presente trabajo se describen tres casos con características clínicas similares, donde se evidencian múltiples pápulas no dolorosas localizadas en mucosa bucal y lengua, mostrando un curso lento y benigno las cuales no habían sido diagnosticadas previamente por dentistas de práctica general. Se llevó a cabo el diagnóstico basado en las características clínicas patognomónicas de las lesiones, historia familiar y evolución; se les dio información a los pacientes acerca de su padecimiento y se mantienen periódicamente en observación. El objetivo de este trabajo es mostrar las características clínicas de la hiperplasia epitelial multifocal y hacer una revisión de la literatura en cuanto a la etiología de las lesiones su evolución, diagnóstico diferencial y tratamiento.
Multifocal epithelial hyperplasia is a benign disease characterized by the presence of multiple papules in oral cavity mucosa. It is as-sociated with HPV 13 and 32. In this paper, we describe three cases with similar clinical features, involving the presence of multiple painless papules localized in the oral mucosa and on the tongue, and displaying a slow and benign course. The condition had not been previously diagnosed by general dental practitioners. We made our diagnosis based on the pathognomonic clinical features of the lesions, family history, and evolution of the condition. The patients concerned were provided with information about their disease and kept under regular observation. The aim of this article is to describe the clinical features of multifocal epithelial hyperplasia and present a review of the literature on the etiology of the lesions, their evolution, differential diagnosis, and treatment.
Subject(s)
Humans , Male , Adolescent , Adult , Female , Child , Focal Epithelial Hyperplasia/diagnosis , Focal Epithelial Hyperplasia/etiology , Focal Epithelial Hyperplasia/therapy , Papillomavirus Infections/pathology , Schools, Dental , Follow-Up Studies , Focal Epithelial Hyperplasia/pathology , Mexico , Mouth Mucosa/injuries , PrognosisABSTRACT
Focal epithelial hyperplasia (FEH) is an asymptomatic benign mucosal disease, which is mostly observed in specific groups in certain geographical regions. FEH is usually a disease of childhood and adolescence and is generally associated with people who live in poverty and of low socioeconomic status. Clinically, FEH is typically characterized by multiple, painless, soft, sessile papules, plaques or nodules, which may coalesce to give rise to larger lesions. Human papillomavirus (HPV), especially genotypes 13 and 32, have been associated and detected in the majority of FEH lesions. The clinical examination and social history often allow diagnosis, but histopathological examination of lesional tissue is usually required to confirm the exact diagnosis. FEH sometimes resolves spontaneously however, treatment is often indicated as a consequence of aesthetic effects or any interference with occlusion. There remains no specific therapy for FEH, although surgical removal, laser excision or possibly topical antiviral agents may be of benefit. There remains no evidence that FEH is potentially malignant.
Subject(s)
Focal Epithelial Hyperplasia/diagnosis , Alphapapillomavirus/isolation & purification , Diagnosis, Differential , Focal Epithelial Hyperplasia/therapy , Humans , Risk FactorsABSTRACT
La hiperplasia epitelial focal (HEF) o enfermedad de Heck, es una afección de la mucosa bucal poco frecuente, producida por el virus del papiloma humano (HPV) subtipos 13 y 32, en un sujeto genéticamente predispuesto. Se presenta en indígenas americanos, afecta a ambos sexos y a edades tempranas. Se caracteriza por pápulas o nódulos múltiples en la cavidad bucal, especialmente en la mucosa labial, yugal y lingual. La evolución es variable y la transformación maligna es posible, pero excepcional. Comunicamos el caso de un paciente de padres bolivianos, con lesiones de un año de evolución, que fue tratado con terapia láser, con buenos resultados
Subject(s)
Humans , Male , Adult , Focal Epithelial Hyperplasia , Focal Epithelial Hyperplasia/pathology , Focal Epithelial Hyperplasia/virology , Oral Manifestations , Amifostine , Argentina , Genetic Predisposition to Disease , Focal Epithelial Hyperplasia/therapy , Indigenous Peoples , Lasers , Mouth Mucosa/radiation effects , Papillomaviridae/pathogenicityABSTRACT
La hiperplasia epitelial focal es una enfermedad poco frecuente de la mucosa oral producida por el virus del papiloma humano. Aparece una proliferación epitelial benigna de predominio en la mucosa del labio inferior. Se asocia fundamentalmente a los serotipos 13 y 32 y existe un claro predominio racial, en indios americanos y esquimales. Presentamos el caso de una chica de 17 años ecuatoriana, con múltiples lesiones papulosas en labio inferior y superior compatibles clínica e histológicamente con hiperplasia epitelial focal. En el estudio por reacción en cadena de la polimerasa se detectó el virus del papiloma humano serotipo 13
Focal epithelial hyperplasia is a rare disease of the oral mucosa caused by the human papilloma virus (HPV). It appears as a benign epithelial growth, usually in the mucosa of the lower lip. It is mainly associated with HPV serotypes 13 and 32 and there is a clear racial predilection for the disease in Native Americans and Eskimos. We describe the case of a 17-year-old girl from Ecuador with multiple papular lesions in both lips that were clinically and histologically consistent with focal epithelial hyperplasia. Analysis by polymerase chain reaction detected HPV serotype 13
Subject(s)
Female , Adult , Humans , Focal Epithelial Hyperplasia/diagnosis , Focal Epithelial Hyperplasia/therapy , Mouth Mucosa/injuries , Mouth Mucosa/physiopathology , Diagnosis, Differential , Mouth/microbiology , Mouth/pathologyABSTRACT
La hiperplasia epitelial focal (HEF) es una proliferación benigna de la mucosa oral con características clínicas e histológicas bien definidas. Se ha asociado a la infección de la mucosa oral por los tipos 13 y 32 del virus del papiloma humano (VPH) y, con menor frecuencia, a otros tipos. Su evolución clínica es variable, aunque suele persistir durante unos meses o años. Se han descrito de resolución espontánea y otros de persistencia prolongada. Se presenta el caso de un niño ecuatoriano que consultó por unas lesiones en la mucosa oral compatibles con el diagnóstico de HEF, que fueron confirmadas en el estudio histológico y en las que se identificó ADN del VPH tipo 13
Focal epithelial hyperplasia (FEH) is a benign proliferation of the oral mucosa with well defined clinical and histological characteristics. It has been associated with infection of the oral mucosa by types 13 and 32 of the human papillomavirus (HPV), and to a lesser extent, with other types. Its clinical course is variable, although it usually persists for months or years; cases with spontaneous resolution have been described, as have others with prolonged persistence. We present the case of an Ecuadorian boy whose visit was motivated by lesions in the oral mucosa consistent with a diagnosis of FEH, which were confirmed in the histological study, and in which HPV type 13 DNA was identified
Subject(s)
Child , Male , Humans , Focal Epithelial Hyperplasia/diagnosis , Focal Epithelial Hyperplasia/therapy , Mouth Mucosa/injuries , Mouth Mucosa/pathology , Papilloma/complications , Keratosis/complications , Immunosuppression Therapy/methods , Electrocoagulation/methods , Cryotherapy/methods , Interferons/therapeutic use , Retinoids/therapeutic use , Focal Epithelial Hyperplasia/complications , Leukoplakia, Oral/complicationsABSTRACT
La hiperplasia multifocal del epitelio (HME) conocida tambiéncomo hiperplasia epitelial focal, enfermedad de Heck ó hiperplasiamultifocal del epitelio por papiloma virus, se caracterizapor la aparición de lesiones múltiples en la mucosa de la cavidadbucal en población pediátrica y se asocia a la presencia del viruspapiloma humano. El objetivo de este estudio fue conocer lascaracterísticas clínico-patológicas de los casos diagnosticadosde esta enfermedad en el Servicio de Dermatología del HospitalManuel Gea González. Se revisaron los archivos de estainstitución y se seleccionaron los casos diagnosticados comoHME. Se encontraron 9 casos. La mayoría de los pacientesfueron menores de 20 años (67%) y del sexo femenino (78%),todos los casos presentaron lesiones múltiples y siempre huboparientes directos con lesiones similares. Los lugares que seafectaron con mayor frecuencia fueron: mucosa bucal, labioinferior, paladar y comisuras. La HME es una condición de lamucosa de la cavidad bucal que solamente necesita tratamientode aquellas lesiones que representan un problema cosmético óaquellas que se traumatizan secundariamente. Las demás remitiránconforme avanza la edad del paciente. Se sugiere usarel nombre de hiperplasia multifocal del epitelio pues describemejor las características clínico-patológicas y microscópicasde la enfermedad
Multifocal epithelial hyperplasia (MEH) is also known as focalepithelial hyperplasia, Hecks disease or multifocal papillomavirus-induced epithelial hyperplasia. It is characterised by thepresence of multiple lesions in the oral mucosa of children andit has been associated with the presence of the human papillomavirus.The aim of this study was to determine the clinicopathologicalfeatures of the cases diagnosed as MEH in theService of Dermatology of the Hospital Manuel Gea González(SDHMGG). The files of the SDHMGG were reviewed and allcases diagnosed as MEH were retrieved. Nine MEH cases werefound. Most of the patients were 20 year-old or younger (67%)and females were more commonly affected (78%). All patientspresented multiple lesions and always, close relatives with similarlesions were found. Lesions were located most commonly inthe buccal mucosa, lower lip and comissures. MEH is a soft tissueintraoral condition that needs treatment solely of the traumatisedlesions or those with cosmetic problems. Remaining lesions willdisappear with the age of the patients. It is suggested that thisentity should be named multifocal epithelial hyperplasia sincethis name describes better the clinico-pathological and microscopicfeatures of the disease
Subject(s)
Male , Female , Child , Adult , Adolescent , Humans , Focal Epithelial Hyperplasia/pathology , Age Factors , Cryotherapy , Family Health , Focal Epithelial Hyperplasia/therapy , Focal Epithelial Hyperplasia/virology , Nitrogen/therapeutic use , Poverty , Retrospective Studies , Sex Ratio , Papillomaviridae/pathogenicityABSTRACT
Multifocal epithelial hyperplasia (MEH) is also known as focal epithelial hyperplasia, Heck's disease or multifocal papillomavirus-induced epithelial hyperplasia. It is characterised by the presence of multiple lesions in the oral mucosa of children and it has been associated with the presence of the human papillomavirus. The aim of this study was to determine the clinico-pathological features of the cases diagnosed as MEH in the Service of Dermatology of the Hospital Manuel Gea González (SDHMGG). The files of the SDHMGG were reviewed and all cases diagnosed as MEH were retrieved. Nine MEH cases were found. Most of the patients were 20 year-old or younger (67%) and females were more commonly affected (78%). All patients presented multiple lesions and always, close relatives with similar lesions were found. Lesions were located most commonly in the buccal mucosa, lower lip and commissures. MEH is a soft tissue intraoral condition that needs treatment solely of the traumatised lesions or those with cosmetic problems. Remaining lesions will disappear with the age of the patients. It is suggested that this entity should be named multifocal epithelial hyperplasia since this name describes better the clinico-pathological and microscopic features of the disease.
Subject(s)
Focal Epithelial Hyperplasia/pathology , Adolescent , Adult , Age Factors , Child , Cryotherapy , Family Health , Female , Focal Epithelial Hyperplasia/therapy , Focal Epithelial Hyperplasia/virology , Humans , Male , Nitrogen/therapeutic use , Papillomaviridae/pathogenicity , Poverty , Retrospective Studies , Sex RatioABSTRACT
La hiperplasia focal del epitelio se caracteriza por la presencia de elevaciones papulares o nodulares, sésiles, de aspecto liso o rugoso, múltiples, de la misma coloración de la mucosa (Neville et al., 1998). Estrada (1956) describió la presencia de verrugas intraorales y lesiones papilomatosas en indios Caramantas en Colombia en 1956. El mismo autor verificó la presencia de esas mismas lesiones en indios Kátios, también colombianos, en el año de 1960. Reyes (1962) notó esa misma condición clínica en Guatemala. Soneira y Fonseca (1964) describieron la lesión con sus variaciones clínicas, desde una pápula a múltiples lesiones papilomatosas en la mucosa oral, labios, entre otras regiones de la mucosa bucal. Estos autores estudiaron 160 niñas indias en Venezuela y observaron la enfermedad en 54 de ellas (33,75 por ciento). Ellos también sugieren que la enfermedad tenga una etiología viral. A pesar de que esta entidad haya sido descrita por otros autores latinoamericanos antes de 1965, a ella se la reconoció internacionalmente ese año a través de Archard, Heck y Stanley. Estos autores relataron casos aislados en 15 indios norteamericanos del estado de Nuevo México; un Xavante, del estado de Mato Grosso (Brasil) y un caso en un niño esquimal de Alaska y pasaron a denominar la entidad Hiperplasia Focal del Epitelio. El epónimo "Enfermedad de Heck" se deriva del Dr. Heck, que identificó a un paciente con esta enfermedad en Gallup, en Nuevo México, en 1961. Practorius-Clausen y Willis (1971) fueron los primeros a demostrar partículas del HPV en la hiperplasia focal del epitelio. Con referencia a las publicaciones anteriores a aquella de Archard, Heck y Stanley (1965), los autores sugieren que el epónimo Enfermedad de Heck sea abandonado, pues esa denominación además de no dar crédito a los autores que la describieron anteriormente a la comunicación de 1965, no suministra ninguna idea con relación a la naturaleza y característica de la entidad. Los autores también relatan un caso de hiperplasia focal del epitelio en paciente del sexo masculino, 13 años, leucodemia (AU)
The focal epithelial hyperplasia is characterized by the presence of papular and nodular elevations, flat or rough multiple sessiles, with the same color of the mucous membrane (Neville et al., 1998). Estrada (1956) described the presence of intra-oral warts and papillary lesions in Caramantas natives in Colombia, in 1956. IN 1960, the same author identified the presence of the same lesions in Kátios natives, from Colombia. Reyes (1962) noticed the same clinical conditions in Guatemala. Soneira and Fonseca (1964) have described the lesion with its clinical variations, from a single papula to multiple papillary lesions in the oral mucosa, lips, and other oral regions. These authors studied 160 native girls in Venezuela and noticed the disease in 54 of them (33.75%). They also suggest that the disease has a viral etiology. In spite of the fact the disease was described by other Latin American authors before 1965, it was worldwide recognized only in this year, due to Aechard, Heck and Stanley. These authors have reported isolated cases in 15 North American natives in the State of New Mexico; one Xavante in the state of Mato Grosso (Brazil) and a Eskimo boy in Alaska, and named the disease as Focal Epithelial Hyperplasia. The eponym "Heck Disease" is derived from Dr. Heck, who identified one patient with this disease in Gallup, New Mexico in 1961. Praetorius-Clausen and WiIlis (1971) were the first to show HPV particles in the focal epithelial hyperplasia. Concerning the publishing prior to Archard, Heck and Stanley (1965), the authors suggest to discard that the eponym "Heck Disease", since this denomination does not add any relation to the nature and characteristics of the disease, and also does not recognize the authors who had described it before 1965. The authors also report a focal epithelial hyperplasia in a male 13 year old patient, leukoderma (AU)
Subject(s)
Adolescent , Adult , Female , Male , Child , Humans , Focal Epithelial Hyperplasia/diagnosis , Papillomaviridae/genetics , Focal Epithelial Hyperplasia/therapy , Mouth Mucosa/physiopathology , Indians, South American/genetics , Carbon Dioxide/therapeutic useSubject(s)
Focal Epithelial Hyperplasia/pathology , Papillomaviridae/isolation & purification , Biopsy, Needle , Child , Combined Modality Therapy , Female , Focal Epithelial Hyperplasia/therapy , Focal Epithelial Hyperplasia/virology , Humans , Immunohistochemistry , Lip/pathology , Mouth Mucosa/pathology , Polymerase Chain Reaction , PrognosisABSTRACT
Niña de 10 años de edad, de raza indo-americana, con placas verrugosas orales de siete meses de evolución. El diagnóstico clínico de hiperplasia epitelial focal fue confirmado por microscopía electrónica. Se realiza la descripción de esta patología frecuente en comunidades indígenas de bajo nivel socioeconómico y su diagnóstico diferencial con otras patologías orales clínicamente similares
Subject(s)
Humans , Female , Focal Epithelial Hyperplasia/diagnosis , Dry Ice/therapeutic use , Focal Epithelial Hyperplasia/pathology , Focal Epithelial Hyperplasia/therapyABSTRACT
Niña de 10 años de edad, de raza indo-americana, con placas verrugosas orales de siete meses de evolución. El diagnóstico clínico de hiperplasia epitelial focal fue confirmado por microscopía electrónica. Se realiza la descripción de esta patología frecuente en comunidades indígenas de bajo nivel socioeconómico y su diagnóstico diferencial con otras patologías orales clínicamente similares (AU)
Subject(s)
Humans , Female , Focal Epithelial Hyperplasia/diagnosis , Focal Epithelial Hyperplasia/pathology , Focal Epithelial Hyperplasia/therapy , Dry Ice/therapeutic useABSTRACT
Presentamos el caso de un paciente con lesiones típicas de hiperplasia eplitelial focal. Dada la escasa frecuencia de esta patología, se realiza una revisión bibliográfica del tema
Subject(s)
Humans , Female , Adult , Focal Epithelial Hyperplasia/history , Focal Epithelial Hyperplasia/physiopathology , Focal Epithelial Hyperplasia/therapy , Diagnosis, Differential , Mouth Mucosa/pathology , Mouth Mucosa/surgeryABSTRACT
Presentamos el caso de un paciente con lesiones típicas de hiperplasia eplitelial focal. Dada la escasa frecuencia de esta patología, se realiza una revisión bibliográfica del tema(AU)
Subject(s)
Humans , Female , Adult , Focal Epithelial Hyperplasia/history , Focal Epithelial Hyperplasia/physiopathology , Focal Epithelial Hyperplasia/therapy , Mouth Mucosa/pathology , Mouth Mucosa/surgery , Diagnosis, DifferentialABSTRACT
We report the first three patients diagnosed with focal epithelial hyperplasia (Heck's disease) in Kenya. Clinically they presented as focal or diffuse papillomatous lesions in the oral mucosa. Histopathological features rule out other similar lesions inter alia multiple fibro-epithelial and viral warts.
