1.
Cancer Treat Rep
; 61(5): 841-7, 1977 Aug.
Article
in English
| MEDLINE
| ID: mdl-890693
ABSTRACT
The distribution of iv administered 3H-dianhydrogalactitol (DAG) in the plasma, cerebrospinal fluid (CSF), brain, and tumor tissue was studied in 11 patients. DAG entered the CSF and was slowly eliminated, with a half-life of 20 hours. Unchanged DAG accounted for about 6%-30% of the total radioactivity in the CSF. All the tumors accumulated the drug to a higher extent than the intact white matter, except the one meningioma studied. The highest uptake was observed in the relatively benign astrocytic tumors.
Subject(s)
Galactitol/metabolism , Glioma/metabolism , Nerve Tissue/metabolism , Sugar Alcohols/metabolism , Adult , Brain/metabolism , Ethers, Cyclic/cerebrospinal fluid , Ethers, Cyclic/metabolism , Galactitol/analogs & derivatives , Galactitol/cerebrospinal fluid , Half-Life , Humans , Middle Aged , Time Factors
2.
Clin Pharmacol Ther
; 13(4): 563-72, 1972.
Article
in English
| MEDLINE
| ID: mdl-5042371
