Systematic Review: Puberty suppression with GnRH analogues in adolescents with gender incongruity.

CONTEXT: Gender incongruence is defined as disharmony between assigned gender and gender identity. Several interventions are liable in this case including genital affirming surgery among other surgical interventions such as harmonization, and also the use of gonadotropin-releasing hormone agonists (GnRHa) for gonadal shielding. This aids in preventing the development of secondary sexual characteristics related to the genetic sex. OBJECTIVE: Systematically review the treatment of gender incongruity with GnRHa analogues. DATA SOURCES: The data source of this research is from Pubmed-Medline and Embase. STUDY SELECTION: Articles published between 2009 and 2019 which studied transgender adolescents treated with GnRHa were carefully selected. DATA EXTRACTION: Were extracted: design, sample size, study context, targeted subjects of intervention, outcome measures, and results. RESULTS: Eleven studies were included. The use of GnRHa seems to be well tolerated by the studied population. When started in pubertal transition, it was associated with a more distinct resemblance to body shape than to the affirmed sex. In addition to preventing the irreversible phenotypic changes that occur in cross-hormonal therapy, the use of GnRHa can equally contribute to the mental health of these adolescents. LIMITATION: There are few consistent studies on the use of GnRHa for gender incongruence. CONCLUSION: As the population of transgender children and adolescents grows, they acquire knowledge and greater access to the various forms and stages of treatment for sex reassignment. The medical community needs to be adequately prepared to better serve this population and offer the safest resources available.

Fertility preservation options for transgender and gender-nonconforming individuals.

PURPOSE OF REVIEW: To provide an overview of the current state of knowledge of fertility risks of gender-affirming therapy, review fertility preservation options for transgender individuals and ways to minimize gender dysphoria during fertility treatment, and identify gaps in knowledge. RECENT FINDINGS: Recent studies have corroborated older data that gender-affirming hormone therapy creates histopathological changes in the gonads; however, the newer data suggests that some function of the gametes may be preserved. One study in transgender men reported successful in-vitro maturation of testosterone-exposed oocytes with normal spindle structures, and recent studies in transgender women reveal early spermatogenesis in estradiol-exposed testes and some recovery of semen parameters following cessation of hormones. Particular attention has recently been given to fertility preservation in transgender adolescents, revealing unmet informational needs in this population and very few are actually pursuing fertility preservation, even with counseling. SUMMARY: There is currently a paucity of data on the fertility effects of gender-affirming hormones, necessitating fertility preservation counseling prior to initiation of therapy. Several modifications can be made to fertility preservation protocols and procedures to decrease gender dysphoria or distress in transgender individuals, but outcome data is still lacking. Achieving high-quality data collection will likely require cooperation across multiple institutions.

Trends in the use of puberty blockers among transgender children in the United States.

BACKGROUND: The objective of the study was to identify national trends in the utilization of histrelin acetate implants among transgender children in the United States. METHODS: We analyzed demographic, diagnostic and treatment data from 2004 to 2016 on the use of histrelin acetate reported to the Pediatric Health Information System (PHIS) to determine the temporal trends in its use for transgender-related billing diagnoses, e.g. "gender identity disorder". Demographic and payer status data on this patient population were also collected. RESULTS: Between 2004 and 2016, the annual number of implants placed for a transgender-related diagnosis increased from 0 to 63. The average age for placement was 14 years. Compared to natal females, natal males were more likely to receive implants (57 vs. 46) and more likely to have implants placed at an older age (62% of natal males vs. 50% of natal females were ≥;13 years; p<0.04). The majority of children were White non-Hispanic (White: 60, minority: 21). When compared to the distribution of patients treated for precocious puberty (White: 1428, minority: 1421), White non-Hispanic patients were more likely to be treated with a histrelin acetate implant for a transgender-related diagnosis than minority patients (p<0.001). This disparity was present even among minority patients with commercial insurance (p<0.001). CONCLUSIONS: Utilization of histrelin acetate implants among transgender children has increased dramatically. Compared to natal females, natal males are more likely to receive implants and also more likely to receive implants at an older age. Treated transgender patients are more likely to be White when compared to the larger cohort of patients being treated with histrelin acetate for central precocious puberty (CPP), thus identifying a potential racial disparity in access to medically appropriate transgender care.

Características de los menores de edad con disforia de género que acuden a la unidad de tratamiento de identidad de género / Caracteristics of adolescents with gender dysphoria referred to the gender identity treatment unit

Fundamentos. La demanda de atención a menores con disforia de género se ha incrementado en los últimos años. El objetivo de la presente investigación fue describir el perfil de adolescentes que solicitaron consulta en la Unidad de Tratamiento de la Identidad de Género del Principado de Asturias (UTIGPA) por presentar quejas de disforia de género.Método. La muestra se compuso de 20 menores de 18 años que fueron atendidos entre marzo de 2007 y diciembre de 2015. Se hizo uso de la historia clínica para recoger la información. Se llevaron a cabo análisis de estadísticos descriptivos y se utilizó la razón sexo/género. Resultados. Los 20 adolescentes representaron el 14,6% de la muestra total (137 personas). Tuvieron una media de edad de 15,20 (DT=1,473) y un rango entre 12 y 17. La razón sexo/género fue de 1/1 (10 pertenecieron al grupo de hombre a mujer y 10 al grupo de mujer a hombre). Cuando llegaron a la unidad el 100% convivía con su familia nuclear o extensa y en el 60% sus padres estuvieron separados. El 70% fue derivado desde salud mental. El 10% no presentó antecedentes asistenciales y al 35% se le prescribió tratamiento psicofarmacológico. El 95% no realizó autotratamiento hormonal. El 100% se definió como heterosexual. El 25% realizó una demanda exclusiva de intervenciones psicológicas y el 75% de tratamientos médicos. Conclusiones. El perfil del menor es un adolescente aproximadamente de 15 años derivado mayoritariamente desde salud mental. La razón sexo/género es la misma para ambos sexos. Presentan antecedentes asistenciales y realiza una demanda prioritaria de tratamientos médicos, tanto hormonales como quirúrgicos (AU)

Background. The demand for treatment among people with gender dysphoria has increased during the last years. The aim of the present research was to carry out an analysis of the demand of the teenagers that requested consultation at the UTIGPA (Gender Identity Treatment Unit of Principality of Asturias) as they presented complains of gender dysphoria. Method. The sample included 20 minors that were treated between March 2007 and December 2015. The clinical history was made to collect information. It was made descriptive analysis and the reason sex/gender was used. Results. The 20 teenagers represented the 14,6% of the whole sample (of 137 demands). The age average was 15,20 years (SD=1,473) and the range of years was between 12-17. The reason sex/gender was 1/1 (10 into the man to woman group and 10 into the woman to man group). At the arrival at the Treatment Unit, 100% of the individuals lived with their nuclear or extended family and in the 60% of the cases, their parents were separated. 70% of the cases were referred from mental health services. 10% hadn ́t got any past medical history and 35% had never received any prescription for a psychopharmacological treatment. 95% hadn’t done any hormonal self-treatment. 100% defined themselves as heterosexual. 25% requested exclusively for psychological interventions and 75% asked for medical treatments. Conclusions. The profile of the minor was a teenager of approximately 15 years old that was referred from mental health services. Contrary to the findings of other national and international researches, the rate sex/gender was equated in our research. The minor had got a past medical history and their priority request was for medical treatments, both hormonal and surgical therapies (AU)

Rasgos psicopatológicos en personas con disforia de género / Psychopathological traits in people with gender dysphoria

Objetivos. En primer lugar, el objetivo es evaluar los rasgos psicopatológicos en personas con disforia de género y, en segundo lugar, establecer si existen diferencias entre los grupos de hombre a mujer y de mujer a hombre. Participantes y método. Se aplicó el Inventario clínico multiaxial de Millon (MCMI-II) a 32 sujetos con disforia de género, de los cuales 20 pertenecen al grupo de hombre a mujer y 12 al de mujer a hombre. Los participantes fueron seleccionados de forma intencional. Resultados. No se encuentran alteraciones psicopatológicas significativas. Las puntuaciones más elevadas se obtuvieron en los rasgos esquizoide, paranoide y delirante. Hay diferencias estadísticamente significativas entre los grupos de hombre a mujer y de mujer a hombre en los patrones clínicos de la personalidad esquizoide (p = 0,012), compulsiva (p = 0,047) y autodestructiva (p = 0,040) y en el síndrome clínico de gravedad moderada abuso de alcohol (p = 0,000). Conclusiones. Las personas con disforia de género no se caracterizan por alteraciones psicopatológicas. Los rasgos con puntuaciones más elevadas se corresponden con los señalados en estudios anteriores. Se aprecian diferencias por grupos, aunque solo en determinadas escalas (AU)

Objectives. Firstly, the aim is to evaluate psychopathological traits in people with gender dysphoria, and secondly, to establish if there are differences between groups of male to female and female to male. Participants and method. The Millon clinical multiaxial inventory (MCMI-II) was applied to 32 subjects with gender dysphoria, of which 20 belong to the group of male to female and 12 to the group female to male. Participants were selected intentionally. Results. No significant psychopathological alterations are found. The highest scores were obtained in the schizoid, paranoid and delusional traits. There are statistically significant differences between the male to female and female to male in clinical patterns of schizoid (P=.012), compulsive (P=.047) and self-destructive personality (P=.040), and in moderate clinical syndrome, abuse of alcohol (P=.000). Conclusions. People with gender dysphoria are not characterized by psychopathological alterations. The traits with higher scores correspond with those pointed out in previous studies. Differences were appreciated between groups, but only in certain scales (AU)

Comentarios sobre las diferencias de disforia de identidad de género entre niños y adolescentes / Comments on differences of gender dysphoria between children and teenagers

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