Subject(s)
Pulmonary Eosinophilia/chemically induced , Valproic Acid/adverse effects , Adrenal Cortex Hormones/therapeutic use , Adult , Anti-Bacterial Agents/therapeutic use , Anxiety Disorders/drug therapy , Bronchoalveolar Lavage Fluid/cytology , Combined Modality Therapy , Depressive Disorder/drug therapy , Diagnosis, Differential , Dyspnea/etiology , Dyspnea/therapy , Female , General Adaptation Syndrome/drug therapy , Humans , Impulsive Behavior/drug effects , Oxygen Inhalation Therapy , Pleural Effusion/chemically induced , Pleural Effusion/pathology , Pulmonary Eosinophilia/diagnosis , Pulmonary Eosinophilia/drug therapy , Respiratory Tract Infections/diagnosis , Suicide, AttemptedABSTRACT
CONTEXT: The anxiety epidemic and its corollary, the widespread prescription of anxiolytics, present a public health problem in view of the risk of addiction to these drugs. OBJECTIVE: To assess the level of anxiety and addiction in the borderline population at risk of addiction. DESIGN: The study analyzed a series of patients in the third month of their first prescription for anxiolytics. It used two validated scales: the Hospital Anxiety and Depression scale (HAD), and a French scale measuring addiction (the "Echelle Cognitive d'Attachement aux Benzodiazepines" or ECAB). RESULT: 83% of patients were still anxious at the third month of treatment. 23% had become addicted. DISCUSSION: There is a contradiction between the prolonged prescription and use of anxiolytics, which are associated with a risk of addiction, and professional guidelines that recommend short treatment for outpatients using these drugs for the first time.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Anxiety Disorders/classification , Substance-Related Disorders/diagnosis , Adult , Aged , Alprazolam/adverse effects , Alprazolam/therapeutic use , Anti-Anxiety Agents/adverse effects , Anxiety Disorders/drug therapy , Benzodiazepines/therapeutic use , Bromazepam/adverse effects , Bromazepam/therapeutic use , Cardiovascular Diseases/complications , Chronic Disease , Depression/classification , Depression/drug therapy , Drug Prescriptions , Female , Follow-Up Studies , France , General Adaptation Syndrome/classification , General Adaptation Syndrome/drug therapy , Humans , Male , Mental Disorders/complications , Middle Aged , Phobic Disorders/classification , Phobic Disorders/drug therapy , Psychometrics , Risk FactorsABSTRACT
The dynamics of total protein biosynthesis and procollagen biosynthesis in skeletal muscle of injury tissues with the antioxidant BHT (dibunol) treatment and with common healing were studied. The obtained date indicate that the AO treatment reduce the rate of biosynthesis both the total proteins and procollagen at the 3th day of healing. Dibunol also considerably reduce the protein biosynthesis in adrenals and brake of corticosteroids biogenesis as measured by ESR-signals intensity of reduced adrenodoxine. AO treatment also reduce the protein biosynthesis in thymus, spleen and bone marrow. The lowering of functional activity of endocrine and immune systems indicate that the AO significantly inhibit the systemic reactions of organism induced by acute wound affect. It was suggested that as "primary mediator" of stress-reaction may be considered lipoperoxide radicals and decay products of lipohydroperoide.
Subject(s)
Antioxidants/pharmacology , Butylated Hydroxytoluene/pharmacology , General Adaptation Syndrome/metabolism , Protein Biosynthesis/drug effects , Wounds, Gunshot/metabolism , Animals , Endocrine System/drug effects , Endocrine System/metabolism , Free Radicals/metabolism , General Adaptation Syndrome/drug therapy , Immune System/drug effects , Immune System/metabolism , Lipid Peroxidation/drug effects , Organ Specificity/drug effects , Rats , Rats, Wistar , Wound Healing/drug effects , Wounds, Gunshot/drug therapyABSTRACT
Radioimmunoassay was used to measure the blood plasma content of endogenous opioid peptides (beta-andorphine, methionin- and leucine-enkephalins), R substance, calcium-regulating hormones (parathyroid hormone and carcitonin), ionized calcium and cortisol in 152 children aged 6 months to 12 years with atopic dermatitis. The data obtained were compared to those obtained in healthy children. The stress-activating and stress-limiting systems were established to be activated in all the patients. It is concluded that the intensity of the adaptation compensatory process depends on the clinical form, disease standing, and spreading of skin impairment.
Subject(s)
Dermatitis, Atopic/blood , General Adaptation Syndrome/blood , Neuropeptides/blood , Child , Child, Preschool , Dermatitis, Atopic/drug therapy , Dermatitis, Atopic/immunology , Drug Therapy, Combination , General Adaptation Syndrome/drug therapy , General Adaptation Syndrome/immunology , Humans , Infant , RadioimmunoassayABSTRACT
Hereby is stated the data of the necessity of the differential approach to the therapy of stress-syndrome taking into consideration the stages of the process. Pharmacological corrections of the oscillations of the antioxidation system of protection during stress is carried out in the stage of quick adaptation and its conversion into long acting, i.e. into the period, when oscillations of biochemical indexes of the antiradical system of protection are compensated. In this an important role is played by using psychotropic substances, which have a quality of the antiradical protection.