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Indian J Pathol Microbiol ; 66(2): 375-378, 2023.
Article in English | MEDLINE | ID: mdl-37077089

ABSTRACT

Pyogenic granulomas represent tumor-like lesions affecting the skin and the oral cavity. This classic definition can be somewhat misleading because such lesion is not associated with infection and lacks any clinical evidence of pus or histological evidence of actual granulation tissue. This case report describes a surgical excision of the growth to exclude angiomatous proliferation. The patient reported a chief complaint of localized gingival overgrowth since 4 months. Intraoral examination revealed an irregular, sessile exuberant growth in respect to labial aspect and interdental gingiva of 31, 32, and 33, measuring about 1.6 × 1.1 cm. Based on the clinical findings, the case was provisionally diagnosed as "pyogenic granuloma". A treatment was planned for the patient. A surgical excision was done irt 31, 32, 33, and the tissue was sent for histopathological examination, which was suggestive of a healing type of pyogenic granuloma.


Subject(s)
Gingival Diseases , Granuloma, Pyogenic , Vascular Neoplasms , Humans , Vascular Neoplasms/complications , Granuloma, Pyogenic/diagnosis , Granuloma, Pyogenic/surgery , Granuloma, Pyogenic/pathology , Gingival Diseases/diagnosis , Gingival Diseases/surgery , Skin/pathology
4.
BMC Oral Health ; 22(1): 154, 2022 04 29.
Article in English | MEDLINE | ID: mdl-35488268

ABSTRACT

BACKGROUND: Up to now, limited research has been done on a significant number of cases with all types of gingival lesion. Besides, the available literature does not provide reliable data on the epidemiology of gingival lesions, especially non-reactive lesions. Thus, the present study aimed to analyze the frequency and distribution of gingival lesions in an Iranian population. METHODS: This retrospective study was conducted on 1000 gingival biopsy samples during 22 years. All lesion types were evaluated in terms of location, clinical signs and symptoms, and patients' age and gender. The data were analyzed using descriptive statistics and chi-square test. RESULTS: Out of the 5284 oral lesions, 1000 (18.92%) gingival lesions were detected, with a female dominance (64.06%). The incidence peak (35.6%) was observed in the third and fourth decades. Non-neoplastic lesions accounted for 92.4% of the cases. The most common reports were related to reactive lesions (71.8%), with the highest prevalence being related to pyogenic granuloma. Additionally, oral squamous cell carcinoma (OSCC) was the most common neoplasm, and exophytic changes and color changes were the most frequent clinical signs. CONCLUSIONS: The study findings indicated the high prevalence of gingival pathological lesions. Although most biopsies were reactive in nature, a few cases were malignant, which must be considered by practitioners. Further research is needed to achieve a clear impression about non-neoplastic lesions so as to develop more helpful oral health planning.


Subject(s)
Carcinoma, Squamous Cell , Gingival Diseases , Mouth Neoplasms , Biopsy , Carcinoma, Squamous Cell/pathology , Female , Gingival Diseases/diagnosis , Humans , Iran , Mouth Neoplasms/epidemiology , Outpatients , Retrospective Studies , United States
7.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 38(6): 718-725, 2020 Dec 01.
Article in Chinese | MEDLINE | ID: mdl-33377354

ABSTRACT

Pregnancy epulis is a tumor-like lesion with high prevalence in China. The local lesion, the general condition of the pregnant patient, and the complications during treatment should be taken into consideration when making a treatment plan for pregnancy epulis. In this study, three representative pregnancy epulis cases were presented, and related studies at home and aboard were reviewed to summarize the etiology, differential diagnosis, treatment, and prevention of pregnancy epulis and share the clinical experience in the treatment of pregnancy epulis.


Subject(s)
Gingival Diseases , Gingival Neoplasms , China , Diagnosis, Differential , Female , Gingival Diseases/diagnosis , Humans , Pregnancy , Prevalence
8.
J Clin Pediatr Dent ; 44(6): 436-441, 2020 Dec 01.
Article in English | MEDLINE | ID: mdl-33378465

ABSTRACT

BACKGROUND: Plasma cell granuloma (PCG) is a rare benign pseudotumorous proliferation of unclear etiology that is mainly situated in the lungs. Gingival PCG is an even more peculiar lesion that usually occurs in middle-aged or elderly individuals and clinically manifests as a solitary entity. CASE REPORT: A 15-year-old male with no underlying medical conditions presented with multiple gingival masses in the right maxilla, which were initially thought to be epulis. The lesions were resected completely and the excisional biopsies sent for histological examination. Immunohistochemical (IHC) stain revealed dense polyclonal plasma cell infiltration with positive expression of both kappa and lambda light chains, confirming a diagnosis of gingival PCG. Subsequently, the affected gingiva healed uneventfully, with no sign of recurrence over 2 years of follow-up. CONCLUSIONS: The present report depicts an extremely unusual case of gingival PCG occurring in a juvenile with multiple lesions, which is worth attention in clinical pediatric dentistry. Excisional-biopsy and histological investigations are imperative for a confirmative diagnosis and to exclude potential aggressive conditions. Complete resection of lesions seems to be a valid treatment, while long-term clinical follow-up is still needed.


Subject(s)
Gingival Diseases , Granuloma, Plasma Cell , Adolescent , Aged , Child , Gingiva , Gingival Diseases/diagnosis , Gingival Diseases/surgery , Granuloma, Plasma Cell/diagnosis , Granuloma, Plasma Cell/surgery , Humans , Male , Middle Aged
9.
Rev. esp. cir. oral maxilofac ; 42(2): 87-90, abr.-jun. 2020. ilus
Article in English | IBECS | ID: ibc-189946

ABSTRACT

Peripheral giant cell granuloma (PGCG) is a benign reactive lesion of the oral cavity. Although PGCG is classified as a tumor-like lesion, it does not represent a true neoplasm, however it is often associated with a response of local irritation and trauma. Clinically, it appears as an exophytic growth with either sessile or pedunculated base, it can be located in gingiva or edentulous alveolar mucosa and usually does not exceed two cm in diameter. The following report describes the case of a 64-year-old female diagnosed with a PGCG of a particularly large size and rapidly evolving, located in the upper jaw area. The lesion was completely excised, and the diagnosis was confirmed by histopathology, there is no apparent recurrence in the area after 12 months of follow-up. A few cases of PGCG greater than 5 cm in diameter have been reported. Furthermore, exceptional cases might present an abnormal rapid growth as well. An opportune diagnosis based on clinical examination, radiographic and histopathological study are fundamental for a prompt and efficient treatment


El granuloma periférico de células gigantes (GPCG) es una lesión reactiva benigna de la cavidad oral en respuesta a una irritación local o a un traumatismo crónico. Si bien es una lesión de aspecto tumoral, no constituye una verdadera neoplasia. Se manifiesta como un crecimiento exofítico de base sésil o pediculada, localizado en encía o procesos alveolares edéntulos y no suele sobrepasar los 2 cm de diámetro. El presente reporte describe el caso de un GPCG de tamaño anormalmente grande y rápida evolución localizado en la zona del maxilar superior en un paciente femenino de 64 años. La biopsia escisional de la lesión confirmó el diagnóstico de GPCG y a 12 meses de seguimiento no se ha presentado recidiva. Se han reportado algunos casos de GPCG de más de 5 cm de diámetro. Además, casos excepcionales también pueden presentar un crecimiento rápido anormal. Un diagnóstico oportuno basado en el examen clínico, radiográfico e histopatológico es fundamental para un tratamiento rápido y eficaz


Subject(s)
Humans , Female , Middle Aged , Granuloma, Giant Cell/diagnosis , Gingival Diseases/diagnosis , Granuloma, Giant Cell/pathology , Granuloma, Giant Cell/surgery , Gingival Diseases/pathology , Gingival Diseases/surgery
11.
BMJ Case Rep ; 13(3)2020 Mar 10.
Article in English | MEDLINE | ID: mdl-32161073

ABSTRACT

Oral focal mucinosis (OFM) is an extremely rare, benign oral soft tissue condition; less than 10 documented cases have been reported in the literature in patients under 18 years old. OFM has an unknown aetiology and predominantly presents in the fourth and fifth decades. The pathogenesis of OFM may be due to fibroblast overproduction of hyaluronic acid. Clinically, it remains almost impossible to diagnose definitively, due to its lack of pathognomonic features, therefore such lesions may have multiple differential diagnoses and histological analysis is essential to confirm OFM. We present an unusual presentation of OFM in a 14-year-old female patient. Following excision, focal myxoid degeneration of the connective tissue was apparent. This case highlights this rare condition for consideration in differential diagnosis of clinically similar lesions.


Subject(s)
Gingival Diseases/diagnosis , Mucinoses/diagnosis , Adolescent , Diagnosis, Differential , Female , Gingival Diseases/pathology , Gingival Diseases/surgery , Humans , Mucinoses/pathology , Mucinoses/surgery
12.
J Cutan Pathol ; 47(3): 257-262, 2020 Mar.
Article in English | MEDLINE | ID: mdl-31568562

ABSTRACT

Bowenoid papulosis (BPap) is an uncommon skin disorder linked to human papillomavirus (HPV) infection and characterized clinically by the presence of scattered papules or small plaques, multiple and pigmented, that involve the stratified squamous epithelium. Bowen disease (BD) is recognized as the main differential diagnosis of BPap. An 80-year old white woman was referred for the evaluation of multiple, brown verrucous papules measuring 3 to 4 mm in diameter on the right maxillary gingiva. Histopathological analysis revealed disturbed epithelial maturation with papillary stratified squamous epithelium, koilocytic dysplasia, parakeratosis, acanthosis, basal double-layer, loss of cellular polarity, nuclear hyperchromatism and pleomorphism, scattered mitosoid bodies, and a high degree of cytologic atypia. An immunohistochemical investigation for p53 and Ki67 showed staining of the basal and suprabasal layer, while p16 was strongly expressed in the nuclei of epithelial cells and Bcl-2 was positive only in mitosoid bodies and the lymphocytic inflammatory infiltrate. In situ DNA hybridization was negative for HPV. Oral BPap is an uncommon lesion in which the diagnostic process includes clinical, histopathological, and molecular correlations due to the similarity to aggressive behavior lesions such as BD.


Subject(s)
Bowen's Disease/diagnosis , Gingival Diseases/diagnosis , Gingival Diseases/pathology , Skin Neoplasms/diagnosis , Aged, 80 and over , Diagnosis, Differential , Female , Humans
13.
J Med Primatol ; 49(1): 47-51, 2020 02.
Article in English | MEDLINE | ID: mdl-31595520

ABSTRACT

Gingival lesions as the sole manifestation of African histoplasmosis (Histoplasma capsulatum var. duboisii) have never been reported in baboons. Grossly, lesions can be indistinguishable from bacterial ulcerative gingivitis or gingival hyperplasia. Clinical outcomes of primary gingival histoplasmosis in baboons are unknown and may complicate colony management decisions.


Subject(s)
Gingival Diseases/veterinary , Histoplasma/isolation & purification , Histoplasmosis/veterinary , Monkey Diseases/diagnosis , Papio , Animals , Diagnosis, Differential , Gingival Diseases/diagnosis , Gingival Diseases/parasitology , Histoplasmosis/diagnosis , Histoplasmosis/parasitology , Male , Monkey Diseases/parasitology
14.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-878401

ABSTRACT

Pregnancy epulis is a tumor-like lesion with high prevalence in China. The local lesion, the general condition of the pregnant patient, and the complications during treatment should be taken into consideration when making a treatment plan for pregnancy epulis. In this study, three representative pregnancy epulis cases were presented, and related studies at home and aboard were reviewed to summarize the etiology, differential diagnosis, treatment, and prevention of pregnancy epulis and share the clinical experience in the treatment of pregnancy epulis.


Subject(s)
Female , Humans , Pregnancy , China , Diagnosis, Differential , Gingival Diseases/diagnosis , Gingival Neoplasms , Prevalence
15.
Turkiye Parazitol Derg ; 43(4): 213-215, 2019 Dec 23.
Article in English | MEDLINE | ID: mdl-31865659

ABSTRACT

The objective of the present study is to present a patient with oral myiasis caused by Calliphoridae larvae. The patient was a 63-year-old male who was transferred from Van Closed Prison to Yüzüncü Yil University, Faculty of Medicine Research and Application Hospital. Five alive larvae localized in different points of gingival region were observed during routine oral cleaning. These larvae belonged to Calliphoridae family. As a result, medical staff should be informed about this infestation and this parasite should be kept in mind especially in risky group of patients and necessary controls should be conducted.


Subject(s)
Diptera , Gingival Diseases/parasitology , Myiasis/parasitology , Animals , Cerebral Hemorrhage/complications , Cerebral Hemorrhage/diagnosis , Diptera/classification , Fatal Outcome , Gingiva/parasitology , Gingival Diseases/diagnosis , Humans , Hypertension/complications , Hypertension/diagnosis , Larva , Male , Middle Aged , Myiasis/diagnosis , Respiration, Artificial , Respiratory Insufficiency/complications , Respiratory Insufficiency/diagnosis , Respiratory Insufficiency/therapy , Turkey
16.
BMJ Case Rep ; 12(12)2019 Dec 17.
Article in English | MEDLINE | ID: mdl-31852693

ABSTRACT

Oral focal mucinosis (OFM) is the rare oral manifestation of cutaneous focal mucinosis. It is a diagnosis made histopathologically, as OFM remains clinically similar to other more common oral lesions, and radiographs do not provide any diagnostic information. This case is a report of a teenage female with left mandibular involvement of an elevated, rounded, asymptomatic, mucosa-coloured lesion in the facial and lingual gingiva between her left first and second mandibular molars. The cause was unclear, although the patient stated that she may have sustained a laceration in that area several months prior. An incisional biopsy revealed histopathological findings consistent with OFM, and complete surgical excision of the lesion was performed under a general anaesthetic, with no signs of recurrence for 2 months. The histological, clinical and accepted treatment methods on OFM will be discussed. Clinicians, including those serving paediatric populations, should consider OFM in their differential diagnoses when evaluating gingival lesions.


Subject(s)
Gingival Diseases/diagnosis , Mucinoses/diagnosis , Adolescent , Biopsy , Gingival Diseases/pathology , Gingival Diseases/surgery , Humans , Mucinoses/pathology , Mucinoses/surgery , Oral Surgical Procedures , Treatment Outcome
17.
BMJ Case Rep ; 12(8)2019 Aug 13.
Article in English | MEDLINE | ID: mdl-31413060

ABSTRACT

Quite a few lesions of the oral cavity specifically of the gingiva have a greater inclination towards women and mostly occur during the first four decades of life, the cause of which may be credited to the changing levels of sex hormones. Out of all such lesions, one lesion whose aetiology is still unclear and which originats from the periosteum or periodontal ligament is central giant cell granuloma. Repeatedly, it is has been described as a reactive lesion, the cause of which may be secondary to local irritants or trauma, specifically plaque or calculus, which is not considered to be a true neoplasm. Here we present a case of a 51-year-old female patient with aggressive gingival growth within 10-13 months of hormonal replacement therapy. The aetiology, histological features and appropriate treatment are discussed in the light of current literature.


Subject(s)
Gingival Diseases/diagnosis , Granuloma, Giant Cell/diagnosis , Diagnosis, Differential , Female , Gingival Diseases/diagnostic imaging , Gingival Diseases/pathology , Gingival Diseases/surgery , Granuloma, Giant Cell/diagnostic imaging , Granuloma, Giant Cell/pathology , Granuloma, Giant Cell/surgery , Hormone Replacement Therapy , Humans , Menopause , Middle Aged
18.
Int J Rheum Dis ; 22(8): 1538-1543, 2019 Aug.
Article in English | MEDLINE | ID: mdl-31062938

ABSTRACT

AIM: Rheumatoid arthritis (RA) and periodontal diseases (PD) are common chronic, inflammatory, destructive and progressive diseases that may have similar pathophysiological mechanisms and risk factors. RA affects more than 1.5% of the world's population, with a higher percentage of females than males. PD is present in around 20% of the population and has multifactorial etiology. The purpose of this study is to describe patients' self-reported oral health and the association with RA disease activity. METHOD: Three hundred patients under treatment for RA from the Division of Rheumatology, Clinical Medicine, North Jutland Region Hospital, Hjørring, Denmark and were eligible for the study. Questionnaires were emailed to the patients and 164 completed answers were received. RESULTS: The mean age of the group of 164 patients (61% female) was 65 ± 11 years. The average value of Disease Activity Score of 28 joints was 2.31 ± 0.83. Only 12% of responders were active smokers. Patients estimated their status of their teeth and gingiva respectively as poor in 13% and 11% of cases, good, in 46% and 49%, and excellent, both as 40%. Spontaneous and/or provoked gingival bleeding were experienced by 15% and 49% of patients. Only 14% of patients declared feelings of loose or movable teeth and 10% declared difficulties in biting or chewing. CONCLUSIONS: The status of oral cavity reported by Danish patients indicates a significant proportion with symptoms of gingival/periodontal disease, which may negatively influence RA activity and disease management. Cooperation between rheumatologists and dentists is important in oral health management in periodontal inflammation.


Subject(s)
Arthritis, Rheumatoid/epidemiology , Gingival Diseases/epidemiology , Oral Health , Periodontal Diseases/epidemiology , Aged , Arthritis, Rheumatoid/diagnosis , Arthritis, Rheumatoid/therapy , Denmark/epidemiology , Female , Gingival Diseases/diagnosis , Humans , Male , Middle Aged , Periodontal Diseases/diagnosis , Risk Factors , Self Report , Severity of Illness Index , Smoking/adverse effects , Smoking/epidemiology
19.
J Med Case Rep ; 13(1): 108, 2019 Apr 26.
Article in English | MEDLINE | ID: mdl-31023388

ABSTRACT

BACKGROUND: Oral focal mucinosis, the oral counterpart of cutaneous focal mucinosis, is a rare disease. As it has no characteristic clinical or radiological features, diagnosis is established by histopathological and immunohistological examination. We present three cases of oral focal mucinosis occurring in the retromolar (which is extremely rare) and gingival regions. CASE PRESENTATION: Case 1 involved a 26-year-old Japanese man with radiolucency in the right retromolar region on panoramic radiograph and computed tomography; no obvious protrusion was observed in the region. This finding was clinically diagnosed as a tumor of the retromolar region. Case 2 involved a 60-year-old Japanese woman. A tumor-like mass of tissue was identified on the buccal gingiva at the maxillary right canine and first premolar region. The lesion measured 7 × 6 mm and exhibited elastic hardness and healthy-colored mucosa. The lesion was diagnosed as an epulis. Case 3 involved a 47-year-old Japanese woman. A tumor-like mass of tissue was identified on the buccal gingiva at the maxillary right canine and first premolar region. The lesion measured 10 × 10 mm and exhibited elastic hardness and redness of the surface mucosa. This lesion was also diagnosed as an epulis. Resection was performed in all three cases, and the lesions were histopathologically diagnosed as oral focal mucinosis. Postoperative courses were uneventful and, thus far, there have been no recurrences. CONCLUSIONS: Although it is difficult to diagnose oral focal mucinosis based on clinical symptoms and imaging findings, the disease should be considered a possibility when diagnosing benign oral tumors. We believe that an emphasis on histopathologic study is essential to confirm the clinical suspicion.


Subject(s)
Gingiva/pathology , Gingival Diseases/diagnosis , Mouth Neoplasms/diagnosis , Mucinoses/pathology , Myxoma/pathology , Adult , Diagnosis, Differential , Female , Gingival Diseases/pathology , Gingival Diseases/therapy , Humans , Male , Middle Aged , Mucinoses/therapy , Myxoma/therapy , Orthognathic Surgical Procedures , Radiography , Treatment Outcome
20.
BMJ Case Rep ; 12(4)2019 Apr 24.
Article in English | MEDLINE | ID: mdl-31023740

ABSTRACT

Gingival pathology is a daily presentation, however a small number of systemic conditions can manifest similar to a common gingival condition and have fatal results. Dentist referred 56-year-old woman to Oral and Maxillofacial Surgery department with a 2-week medical history of gingival bleeding not responding to local measures. Biopsy showed eosinophilic infiltrate and vasculitis, and blood tests showed positive markers including cytoplasmic antineutrophil cytoplasmatic antibodies. Granulomatosis with polyangiitis is a rare disease affecting the respiratory tract, blood vessels and kidneys. Oral lesions are rarely the primary presenting feature. When left untreated, most cases are fatal within a year of diagnosis. The diagnosis can only be made when certain criteria are found, including granular oral lesions exhibiting an eosinophilic inflammatory infiltrate on biopsy. With 5% of cases showing intraoral lesions as the primary feature, it is essential that dentists have the knowledge of this rare disease to refer and not to treat as a common gingival condition.


Subject(s)
Dentists/education , Gingival Diseases/diagnosis , Granulomatosis with Polyangiitis/pathology , Oral Ulcer/etiology , Aftercare , Anti-Bacterial Agents/therapeutic use , Antibodies, Antineutrophil Cytoplasmic/metabolism , Biopsy , Diagnosis, Differential , Eosinophils/pathology , Female , Giant Cells, Foreign-Body/pathology , Gingival Diseases/pathology , Glucocorticoids/therapeutic use , Granulomatosis with Polyangiitis/blood , Granulomatosis with Polyangiitis/drug therapy , Hemorrhage/diagnosis , Hemorrhage/etiology , Humans , Middle Aged , Oral Ulcer/diagnosis , Oral Ulcer/drug therapy , Prednisolone/administration & dosage , Prednisolone/therapeutic use , Rare Diseases , Treatment Outcome , Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosage , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
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