ABSTRACT
Cascade filtration (CF) was applied to patients with advanced cancers. To selectively remove immunosuppressive factors with molecular weight lower than albumin, adsorbents combined with CF were examined. Among 11 kinds of adsorbents, glassbead adsorbents with pore size 100A were the most effective in adsorbing such substances. Clinically, a column packed with glassbead adsorbents was concomitantly used with CF. The second filtrate was passed through the column and returned to the patient. The removal rate of immunosuppressive substances with molecular weight lower than albumin was only 20% by CF alone, but more than 50% by CF combined with glassbead adsorbents. Clinical symptoms such as severe back pain and general malaise were drastically improved during and after therapy. These results suggest that CF combined with glassbead adsorbents is an effective adjunctive modality to cancer therapy.
Subject(s)
Immune Tolerance , Neoplasms/therapy , Adsorption , Filtration/instrumentation , Filtration/methods , Glass/therapeutic use , HumansABSTRACT
The tolerance of the inner ear to fibrin tissue adhesive was tested. In experimental surgery on thirty-four chinchilla ears, Fibrin Sealant was applied to the inner ear contents by closing the oval window with a connective tissue graft dipped in the adhesive and gluing a Macor glass ceramic strut between this graft and tympanic membrane. No inner ear changes or tissue damage were found. The loss in auditory sensitivity monitored by auditory brain stem response thresholds was commensurate with the amount of loss to be expected with ossicular chain replacement. The findings suggest that this tissue glue can be safely applied to the labyrinth.
Subject(s)
Factor XIII/therapeutic use , Fibrinogen/therapeutic use , Fibronectins/therapeutic use , Glass/therapeutic use , Oval Window, Ear/surgery , Thrombin/therapeutic use , Tissue Adhesives/therapeutic use , Vestibule, Labyrinth/surgery , Animals , Audiometry, Evoked Response , Chinchilla , Connective Tissue/transplantation , Drug Combinations/therapeutic use , Ear, Inner/anatomy & histology , Ear, Inner/drug effects , Fibrin Tissue Adhesive , Prostheses and Implants , Stapes Surgery/methodsABSTRACT
The newly developed bioactivated bone cement Palavital is composed of polymethylmethacrylate, glass fibers and bioactive glass ceramic. The superficially located glass ceramic particles offer the possibility of true bonding of the bone cement to the bony implantation bed. Reconstruction of the frontal sinuses and the skull was performed on 9 dogs. The follow up was 14 days to 5 years. The implants were checked by tomography and histology. All implants were tolerated without any inflammatory reaction. The bond between bone and implant was demonstrated. Palavital seems to be an improvement on bone cement on a polymethylmethacrylate base.
