ABSTRACT
La indicación en la cirugía de sustitución protésica del hombro ha cambiado de una forma drástica en los últimos años, hemos pasado del tratamiento con prótesis parciales para fracturas agudas al uso de prótesis inversas, la prótesis anatómica ha perdido terreno hasta el punto de que en muchos hospitales la prótesis invertida ha superado con creces a la prótesis anatómica. También podemos decir que las indicaciones de prótesis han variado, así hemos ampliado el uso de la prótesis inversa que fue desarrollada para el tratamiento de las artropatías por manguito rotador. Estos implantes en la actualidad se usan además como recurso para fracturas y recambios. En este artículo intentamos hacer una puesta al día de los problemas más frecuentes de las artroplastias y además se hace una revisión de lo publicado en los últimos años haciendo mayor hincapié en los artículos publicados en el JSES, JBJS y los ICL de la AAOS. De forma resumida se valoran las complicaciones que afectan a las prótesis de hombro
Changes in replacement surgery in the shoulder have happened recently: reverse shoulder prosthesis for acute fractures, and more indications for reverse shoulder arthroplasty than before. In this paper an update of most frequent concepts in shoulder surgery during 2015 is performed
Subject(s)
Humans , Male , Female , Arthroplasty/methods , Arthroplasty/standards , Prostheses and Implants/classification , Prostheses and Implants/standards , Joint Instability/complications , Joint Instability/pathology , Glenoid Cavity/injuries , Osteoarthritis/diagnosis , Osteoarthritis/pathology , Arthritis, Rheumatoid/pathology , Arthroplasty/classification , Arthroplasty/rehabilitation , Prostheses and Implants/supply & distribution , Prostheses and Implants , Joint Instability/rehabilitation , Joint Instability/therapy , Glenoid Cavity/metabolism , Osteoarthritis/rehabilitation , Osteoarthritis/therapy , Arthritis, Rheumatoid/metabolismABSTRACT
The role of short stature homeobox 2 (shox2) in the development and homeostasis of the temporomandibular joint (TMJ) has been well documented. Shox2 is known to be expressed in the progenitor cells and perichondrium of the developing condyle. A previous study by our group reported that overexpression of shox2 leads to congenital dysplasia of the TMJ via downregulation of the Indian hedgehog (Ihh) signaling pathway, which is essential for embryonic disc primordium formation and mandibular condylar growth. To determine whether overexpression of Ihh may rescue the overexpression of shox2 leading to congenital dysplasia of the TMJ, a mouse model in which Ihh and shox2 were overexpressed (Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice) was utilized to assess the consequences of this overexpression on TMJ development during post-natal life. The results showed that the developmental process and expression levels of runt-related transcription factor 2 and sex determining region Y-box 9 in the TMJ of the Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice were similar to those in wildtype mice. Overexpression of Ihh rescued shox2 overexpression-associated reduction of extracellular matrix components. However, overexpression of Ihh did not inhibit the shox2 overexpression-associated increase of matrix metalloproteinases (MMPs) MMP9, MMP13 and apoptosis in the TMJ. These combinatory cellular and molecular defects appeared to account for the observed congenital dysplasia of TMJ, suggesting that overexpression of Ihh partially rescued shox2 overexpressionassociated congenital dysplasia of the TMJ in mice.
Subject(s)
Bone Diseases, Developmental/pathology , Hedgehog Proteins/metabolism , Homeodomain Proteins/metabolism , Temporomandibular Joint Disorders/pathology , Animals , Apoptosis , Bone Diseases, Developmental/congenital , Bone Diseases, Developmental/metabolism , Core Binding Factor Alpha 1 Subunit/metabolism , Glenoid Cavity/metabolism , Hedgehog Proteins/genetics , Homeodomain Proteins/genetics , Matrix Metalloproteinase 13/metabolism , Matrix Metalloproteinase 9/metabolism , Mice , Mice, Transgenic , SOX9 Transcription Factor/metabolism , Temporomandibular Joint Disorders/congenital , Temporomandibular Joint Disorders/metabolism , Up-RegulationABSTRACT
PURPOSE: Failures in total shoulder replacements are often due to aseptic loosening of the glenoid component; the subchondral bone plate is an important factor governing primary fixation of implant materials. Therefore, we investigated characteristic mineralisation patterns of the subchondral bone plate, which demonstrate long-term stress on articular surfaces, age-related changes, postsurgical biomechanical situations and regions of fixation. Using computed tomography osteo-absorptiometry (CT-OAM), these distribution patterns can be demonstrated in vivo. The aim of this study was to investigate the relationship between subchondral bone-plate mineralisation measured with CT-OAM and the mechanical strength measured by indentation. METHODS: A total of 32 cadaverous glenoid cavities were evaluated by CT-OAM and indentation testing. Linear regression was used to compare mineralisation and strength of the subchondral bone plate. RESULTS: Results showed two patterns of mineralisation distribution. Twenty-eight cavities were related to bicentric distribution pattern and four showed a single maximum. The correlation coefficient between CT-OAM density and subchondral bone-plate strength was determined to be between 0.62 and 0.96 (P < 0.02). CONCLUSIONS: Long-term stress affects not only the subchondral but also the underlying cancellous bone. It therefore can be assumed that mineralisation patterns of the subchondral bone plate continue in cancellous bone. Areas of high density could serve as anchoring locations for orthopaedic implants in resurfacing the glenoid cavity.
