ABSTRACT
Two autoimmune diseases that can negatively affect kidney function are systemic lupus erythematosus (SLE) and immunoglobulin A (IgA) nephropathy. Autoimmune diseases occur when autoantibodies attack intrinsic tissue and generate inflammation in multiple body tissues, sometimes targeting specific organs. There is no cure for either SLE or IgA nephropathy, but both disorders may be medically managed.
Subject(s)
Glomerulonephritis, IGA/drug therapy , Lupus Erythematosus, Systemic/complications , Cyclophosphamide/therapeutic use , Glomerulonephritis, IGA/complications , Glomerulonephritis, IGA/nursing , Glucocorticoids/therapeutic use , Humans , Mycophenolic Acid/therapeutic useABSTRACT
La nefropatía por IgA, cuya incidencia en la población pediátrica oscila entre 1.5 y 56.21 según reportes publicados en el sur de Europa, Australia y Japón, se reporta como primera causa de glomerulonefritis primaria en niños. La nefropatía por IgA puede ser primaria o secundaria, se diagnostica por demostración de IgA predominantemente mesangial o IgA codominante en el glomérulo sin evidencia de lupus eritematoso. La mayoría de los pacientes presenta hematuria macroscópica y el pronóstico depende de los marcadores genéticos y la severidad de la lesión histológica renal. A continuación presentamos el reporte de un caso de una paciente con evidencia de hipotiroidismo primario autoinmune y nefropatía por IgA.
Subject(s)
Humans , Child , Female , Glomerulonephritis, IGA/diagnosis , Glomerulonephritis, IGA/drug therapy , Glomerulonephritis, IGA/epidemiology , Glomerulonephritis, IGA/etiology , Glomerulonephritis, IGA/genetics , Glomerulonephritis, IGA/history , Glomerulonephritis, IGA/nursing , Glomerulonephritis, IGA/physiopathology , Hypothyroidism/congenital , Hypothyroidism/drug therapy , Hypothyroidism/etiology , Hypothyroidism/genetics , Hypothyroidism/nursingABSTRACT
Berger's disease or IgA nephropathy is a common form of glomerulonephritis that falls under the broad diagnostic category of primary glomerulonephritis. Diagnosis is made by clinical presentation and morphological changes noted on a biopsy of renal tissue. The exact cause is not known. The literature does implicate an immune-complex mediated syndrome and/or a defect in mucosal immunity as possible pathogenic mechanisms. With the advances made in diagnostic techniques, IgA nephropathy is now recognized as the most common type of glomerulonephritis in the world.
