Subject(s)
Ascorbic Acid/pharmacology , Erythrocyte Aging , Erythrocytes/metabolism , Ferricyanides/pharmacology , Glucosephosphate Dehydrogenase Deficiency/blood , Glucosephosphate Dehydrogenase/blood , Oxidation-Reduction/drug effects , Drug Resistance , Erythrocytes/drug effects , Glucosephosphate Dehydrogenase Deficiency/congenital , Humans , In Vitro Techniques , NADP/biosynthesis , NADP/bloodABSTRACT
Clinical and immunological characteristics of the tuberculosis process in patients with mental diseases and congenital deficiency of glucose-6-phosphate dehydrogenase were investigated. Enzymopathy was detected in 34 (8.9 per cent) out of 382 patients subjected to the investigation. It was shown that among the carriers of the anomalous gene, the proportion of patients with chronic destructive tuberculosis was high. The patients (91.2%) showed more frequent bacterial isolation. Despite immunotherapy, no positive changes in the immunological indices were observed in the carriers, which was attributable to decreased activity of the enzyme in the immunocompetent cells.
Subject(s)
Glucosephosphate Dehydrogenase Deficiency/complications , Mental Disorders/complications , Tuberculosis, Pulmonary/complications , Adolescent , Adult , Aged , Female , Glucosephosphate Dehydrogenase Deficiency/congenital , Glucosephosphate Dehydrogenase Deficiency/immunology , Humans , Male , Mental Disorders/immunology , Middle Aged , Tuberculosis, Pulmonary/immunologySubject(s)
Hemolysis/drug effects , Absorption , Acute Kidney Injury/complications , Disseminated Intravascular Coagulation/complications , Disulfides/metabolism , Erythrocyte Membrane/metabolism , Female , Globins/metabolism , Glucosephosphate Dehydrogenase Deficiency/congenital , Hemoglobinopathies/chemically induced , Hemoglobins/metabolism , Humans , Infant, Newborn , Lipid Metabolism , Male , Methemoglobin/metabolism , Methemoglobinemia/complications , Oxidation-Reduction , Phenacetin/adverse effects , Sulfhemoglobin/metabolism , Sulfonamides/adverse effectsSubject(s)
Glucosephosphate Dehydrogenase Deficiency/congenital , Heroin Dependence , Infant, Newborn, Diseases , Methadone/adverse effects , Pregnancy Complications , Substance Withdrawal Syndrome , Adult , Drug Antagonism , Female , Humans , Infant, Newborn , Infant, Newborn, Diseases/chemically induced , Jaundice, Neonatal/chemically induced , Jaundice, Neonatal/etiology , PregnancySubject(s)
Glucosephosphate Dehydrogenase Deficiency/epidemiology , Child , Child, Preschool , Favism/complications , Female , Glucosephosphate Dehydrogenase Deficiency/congenital , Glucosephosphate Dehydrogenase Deficiency/etiology , Humans , Infant , Infant, Newborn , Italy , Male , Mass ScreeningABSTRACT
Deficiency of red cell glucose-6-phosphate dehydrogenase was found in a native Danish family, in which 2 boys suffered from severe haemolytic anaemia. The mother and 3 sisters of the boys were heterozygotes for G-6-PD deficiency. The biochemical investigations indicate that this deficient G-6-PD is very similar to the Mediterranean variant; however, this variant gene may represent another example of G-6-PD 'Helsinki' or an unique variant with properties similar to G-6-PD B(--).
Subject(s)
Anemia, Hemolytic, Congenital/genetics , Glucosephosphate Dehydrogenase Deficiency/genetics , Adult , Anemia, Hemolytic, Congenital/enzymology , Child , Child, Preschool , Denmark , Erythrocytes/enzymology , Female , Glucosephosphate Dehydrogenase Deficiency/congenital , Heterozygote , Humans , Male , PedigreeSubject(s)
Anemia, Hemolytic, Congenital/complications , Glucosephosphate Dehydrogenase Deficiency/complications , Hyperbilirubinemia/complications , Infant, Newborn, Diseases , Jaundice, Neonatal/complications , Female , Glucosephosphate Dehydrogenase Deficiency/congenital , Humans , Hyperbilirubinemia, Hereditary , Infant, Newborn , MaleABSTRACT
A total of 889 cord blood samples collected from newborn infants of both sexes and 563 samples of venous blood collected from adult males in Iraq were examined for evidence of glucose-6-phosphate dehydrogenase (G6PD) deficiency. The deficiency was proved to exist in all ethnic groups in Iraq and in both adult males and infants. The overall incidence of the deficiency was 8.9% in the adults and 8.4% in the infants. The difference is not statistically significant. Evidence is given to suggest that favism ("khsaissa") is known to the people of southern Iraq.
