Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 5 de 5
Filter
Add more filters










Database
Language
Publication year range
1.
Biochem Soc Trans ; 39(5): 1334-40, 2011 Oct.
Article in English | MEDLINE | ID: mdl-21936811

ABSTRACT

N-glycans are key players mediating cell-cell communication in the immune system, interacting with glycan-binding proteins. In the present article, we discuss key themes that are emerging from the structural analysis of complex-type N-linked glycans from human and murine immune cell lines, employing high-sensitivity MALDI (matrix-assisted laser desorption ionization)-TOF (time-of-flight) MS technology. Particular focus is given to terminal epitopes, the abundance of multiply branched N-glycans and how glycosylation can affect human health in diseases such as congenital neutropenia and glycogen storage disease.


Subject(s)
Glycomics/methods , Immune System/physiology , Polysaccharides/chemistry , Animals , Carbohydrate Conformation , Carbohydrate Sequence , Cell Line , Epitopes/chemistry , Glycogen Storage Disease/immunology , Glycosylation , Humans , Molecular Sequence Data , Neutropenia/congenital , Neutropenia/immunology , Neutrophils/chemistry , Neutrophils/immunology , Sensitivity and Specificity , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
3.
Acta Pathol Jpn ; 37(6): 941-6, 1987 Jun.
Article in English | MEDLINE | ID: mdl-2442960

ABSTRACT

Antisera against Lafora bodies were made in rabbits by subcutaneous injection of the myocardium from a patient died of Lafora disease. Using this antisera, immunohistochemistry revealed that corpora amylacea, the basophilic degeneration of myocardium and deposits of type IV glycogenosis contained the materials which were antigenically common to Lafora bodies.


Subject(s)
Amyloid/analysis , Epilepsies, Myoclonic/immunology , Glycogen Storage Disease Type IV/immunology , Glycogen Storage Disease/immunology , Inclusion Bodies/immunology , Liver/ultrastructure , Myocardium/pathology , Epilepsies, Myoclonic/pathology , Glycogen Storage Disease Type IV/pathology , Histocytochemistry , Humans , Immune Sera/immunology , Myocardium/ultrastructure , Staining and Labeling
SELECTION OF CITATIONS
SEARCH DETAIL
...