ABSTRACT
Before 1950, cases of necrotizing vasculitis were commonly published in journals of pathology. Most of these cases were designated as polyarteritis nodosa. In 1952, the pathologist Pearl Zeek critically reviewed and summarized the literature dealing with polyarteritis nodosa and first grouped the different types of necrotizing vasculitis. But she omitted some types of not well-characterized vasculitis, among them granulomatosis with polyangiitis (Wegener's granulomatosis).
Antes de 1950, los casos de vasculitis necrosantes comúnmente se publicaban en revistas de patología. La mayoría de los casos se designaban poliarteritis nodosa. En 1952, la patóloga Pearl Zeek revisó críticamente la literatura sobre poliarteritis nodosa y por primera vez agrupó los diferentes tipos de vasculitis necrosantes. Sin embargo, omitió algunos tipos de vasculitis, hasta entonces no bien caracterizadas, entre las cuales estaba la granulomatosis con poliangeítis (antes granulomatosis de Wegener).
Subject(s)
Granulomatosis with Polyangiitis/history , Germany , Granulomatosis with Polyangiitis/diagnosis , History, 20th Century , Humans , New YorkABSTRACT
In this essay we describe a number of the known and not so known experiences of the early anti-neutrophil cytoplasmic antibodies (ANCAs) days, explaining why and how we reached consensus on the standard indirect immunofluorescence (IIF) techniques, the naming of the two principal C- and P-ANCA patterns, why we chose to use IIF as the standard technique, how the solid phase assays have developed and where we stand today, the use of ANCA for diagnosis and the importance of using several techniques for that purpose, how ANCA titres are related to disease activity and the clinical impact of this, and finally the implications of ANCA being a natural, polyclonal antibody response against various epitopes in relation to diagnostics and disease patterns.
Subject(s)
Antibodies, Antineutrophil Cytoplasmic/history , Biomarkers , Fluorescent Antibody Technique, Indirect/history , Granulomatosis with Polyangiitis/history , Antibodies, Antineutrophil Cytoplasmic/blood , Autoantigens/history , Autoantigens/immunology , Fluorescent Antibody Technique, Indirect/standards , Granulomatosis with Polyangiitis/immunology , History, 20th Century , History, 21st Century , HumansSubject(s)
Granulomatosis with Polyangiitis/history , Germany , History, 20th Century , Humans , United StatesABSTRACT
This article describes the history and significance of the eponym 'Wegener'. After the American College of Chest Physicians awarded Wegener with the Master Clinician Award, discussion about his Nazi past arose. Should the eponym 'Wegener' be maintained?
Subject(s)
Granulomatosis with Polyangiitis/history , National Socialism/history , Germany , History, 20th CenturyABSTRACT
The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry, oral and maxillofacial medicine, oral and maxillofacial pathology and oral, oral and maxillofacial radiology and maxillofacial surgery) and particularly by hospital-centred practitioners. This series has selected some of the more recognized relevant eponymous conditions and presents them alphabetically. The information is based largely on data available from MEDLINE and a number of internet websites as noted below: the authors would welcome any corrections. This document summarizes data about Wegener granulomatosis.
