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1.
Clin Exp Rheumatol ; 35(4): 674-677, 2017.
Article in English | MEDLINE | ID: mdl-28339366

ABSTRACT

OBJECTIVES: Jaccoud's arthropathy (JA) is a deforming, non-erosive arthritis, occurring in 2-35% of systemic lupus erythematosus (SLE) patients. We aimed to evaluate JA patients in a wide monocentric SLE cohort in terms of clinical, serological and ultrasonographic features. METHODS: Consecutive SLE patients (ACR criteria 1997) were evaluated. The JA index was applied for patients with reducible deformities. Patients with a JA index ≥5 underwent physical examination, blood testing and ultrasound (US) assessment. Detection of anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) was performed. A single rheumatologist performed the US assessment of bilateral wrist and hands. RESULTS: Four hundred and eighty SLE patients were evaluated: 17 (3.5%) showed a JA index ≥5 (M:F 1:16; mean age±SD 50.7±11.1 years; mean disease duration±SD 247.8±116.2 months). Four patients (23.5%) showed ACPA positivity. Fifteen patients (88.2%) showed at least one US abnormality. Bone erosions were found in 10 patients (58.8%). ACPA+ve patients showed erosive damage more frequently in at least one joint compared with ACPA-ve (75% vs. 53.8%, p=0.002). CONCLUSIONS: JA should no longer be considered a non-erosive condition since bone damage can occur in more than half of patients. Moreover, the erosive damage seems to be associated with the presence of ACPA.


Subject(s)
Bone Diseases/diagnostic imaging , Hand Deformities, Acquired/diagnostic imaging , Joint Diseases/diagnostic imaging , Lupus Erythematosus, Systemic/complications , Wrist Joint/diagnostic imaging , Adult , Autoantibodies/immunology , Bone Diseases/etiology , Female , Hand Deformities, Acquired/etiology , Hand Deformities, Acquired/immunology , Hand Joints/diagnostic imaging , Humans , Joint Diseases/etiology , Joint Diseases/immunology , Lupus Erythematosus, Systemic/immunology , Male , Middle Aged , Peptides, Cyclic/immunology , Rheumatoid Factor/immunology
3.
J Clin Rheumatol ; 22(1): 1-7, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26693619

ABSTRACT

OBJECTIVE: The aim of this study was to determine the prevalence, spectrum, and clinical, radiological, and serologic findings as well as hand functions among Thai systemic lupus erythematosus (SLE) patients with deforming arthropathy. METHODS: All SLE patients attending the rheumatology clinic between January and December 2012 were interviewed, with their complete history and a physical examination being taken. Those with hand deformities were invited to join the study. RESULTS: Forty (8.7%) of 458 SLE patients had deforming arthropathy, with 13 (2.8%) of them having erosive arthritis (EA group) and 27 nonerosive arthropathy (NEA group) (8 [1.8%] with Jaccoud arthropathy [JA subgroup] and 19 [4.1%] with mild deforming arthropathy [MDA subgroup]). Three of 13 EA patients (0.7% of all SLE patients) had high titer of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies that might represent true overlapping between rheumatoid arthritis and SLE. There were no statistically significant differences in autoantibodies, RF, or anti-CCP between the EA and NEA groups or the JA and MDA subgroups, except for discoid rash that was seen more commonly in the MDA subgroup. Rheumatoid factor and anti-CCP were not present in the JA subgroup. Hand joint destruction and deformities were seen more commonly in the EA group and JA subgroup. The hand grip and palmar pinch strength decreased moderately, with hand functions quite well preserved in all groups. CONCLUSIONS: Deforming arthropathy was not uncommon in Thai SLE patients, but true overlapping between rheumatoid arthritis and SLE was rare. Despite significant hand joint deformities and moderately decreased hand grip and palmar pinch strength, preservation of hand functions was generally apparent.


Subject(s)
Arthritis, Rheumatoid/epidemiology , Hand Deformities, Acquired/epidemiology , Lupus Erythematosus, Systemic/complications , Adult , Arthritis, Rheumatoid/complications , Arthritis, Rheumatoid/immunology , Autoantibodies/blood , Female , Follow-Up Studies , Hand Deformities, Acquired/etiology , Hand Deformities, Acquired/immunology , Humans , Incidence , Lupus Erythematosus, Systemic/blood , Lupus Erythematosus, Systemic/epidemiology , Male , Middle Aged , Peptides, Cyclic/blood , Peptides, Cyclic/immunology , Prevalence , Retrospective Studies , Rheumatoid Factor/blood , Thailand/epidemiology
4.
Int J Rheum Dis ; 19(3): 312-20, 2016 Mar.
Article in English | MEDLINE | ID: mdl-25293362

ABSTRACT

BACKGROUND: Anti-topoisomerase I antibody (ATA) carries an increased risk of systemic sclerosis (SSc) internal organ involvement. There have been no published comparisons of the clinical characteristics of patients positive and negative for ATA in Thailand, where the positive rate for ATA is higher than among Caucasians. OBJECTIVE: To define the clinical differences between SSc, positive versus negative, for ATA. METHODS: A retrospective cohort study was performed among SSc patients over 18 at Srinagarind Hospital, Khon Kaen University, Thailand, during January 2006-December 2013. SSc-overlap syndrome was excluded. RESULTS: Two hundred and ninety-four SSc patients were included (female : male 2.5 : 1). The majority (68.6%) were the diffuse cutaneous SSc subset (dcSSc). ATA was positive in 252 patients (85.7%), among whom 71.7% had dcSSc and 28.2% limited cutaneous SSc (lcSSc). Using a multivariate analysis, hand deformity had a significantly positive association with ATA (odds ratio [OR] 7.01; 95% CI 1.02-48.69), whereas being anti-centromere (ACA) positive had a negative association (OR 0.17; 95% CI 0.03-0.92). After doing a subgroup analysis of the SSc subset, the median duration of disease at time of pulmonary fibrosis detection among ATA positive dcSSc was significantly shorter than the ATA negative group (1.05 vs. 6.77 years, P = 0.01). Raynaud's phenomenon (RP) at onset was significantly more frequent in lcSSc sufferers who were ATA negative than those who were ATA positive (90.5% vs. 56.9%, P = 0.005). CONCLUSIONS: A high prevalence of ATA positivity was found among Thai SSc patients and this was associated with a high frequency of hand deformity, ACA negativity, a short duration of pulmonary fibrosis in dcSSc and a lower frequency of RP in lcSSc.


Subject(s)
Autoantibodies/blood , DNA Topoisomerases, Type I/immunology , Scleroderma, Diffuse/immunology , Scleroderma, Limited/immunology , Adolescent , Adult , Aged , Biomarkers/blood , Chi-Square Distribution , Female , Hand Deformities, Acquired/epidemiology , Hand Deformities, Acquired/immunology , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Odds Ratio , Predictive Value of Tests , Prevalence , Pulmonary Fibrosis/epidemiology , Pulmonary Fibrosis/immunology , Raynaud Disease/epidemiology , Raynaud Disease/immunology , Retrospective Studies , Risk Factors , Scleroderma, Diffuse/blood , Scleroderma, Diffuse/diagnosis , Scleroderma, Diffuse/epidemiology , Scleroderma, Limited/blood , Scleroderma, Limited/diagnosis , Scleroderma, Limited/epidemiology , Serologic Tests , Thailand/epidemiology , Young Adult
5.
J Dtsch Dermatol Ges ; 13(12): 1257-66, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26612796

ABSTRACT

BACKGROUND: A genetic blistering skin disease, recessive dystrophic epidermolysis bullosa (RDEB), is marked by severe wound healing defects and finger contractures. The purpose of this investigation was to elucidate the mechanisms of impaired wound healing and pseudosyndactyly occurring in RDEB patients by studying the role of known inflammation and fibrosis markers in RDEB pseudosyndactyly tissue. PATIENTS AND METHODS: We studied the expression of the fibrosis and/or inflammation markers tenascin-C, α-smooth muscle actin, transforming growth factor-ß1, interleukin-1ß, and interleukin-6 in scarring and nonscarring tissue from healthy donors and RDEB patients by semiquantitative real time-PCR and, where applicable, by immunoblots. Furthermore, the distribution pattern of α-smooth muscle actin and tenascin-C were assessed by immunofluorescence microscopy. RESULTS: Based on mRNA and protein analysis, we found upregulation of tenascin-C, interleukin-1ß, and interleukin-6 - but not of transforming growth factor-ß1 - in recessive dystrophic epidermolysis bullosa scar samples taken from pseudosyndactyly hands. Unexpectedly, α-smooth muscle actin was not upregulated. CONCLUSIONS: Our results confirm inflammation and fibrosis in recessive dystrophic epidermolysis bullosa, especially in scars, suggesting major roles for these processes in pseudosyndactyly. Our data therefore suggests the potential use of antiinflammatory and antifibrotic drugs in the prevention of pseudosyndactyly.


Subject(s)
Dermatitis/immunology , Epidermolysis Bullosa Dystrophica/immunology , Hand Deformities, Acquired/immunology , Skin/immunology , Skin/pathology , Wound Healing/immunology , Adolescent , Adult , Aged , Cytokines/immunology , Dermatitis/pathology , Epidermolysis Bullosa Dystrophica/pathology , Female , Fibrosis/immunology , Fibrosis/pathology , Humans , Immunologic Factors/immunology , Male , Middle Aged , Young Adult
6.
J Rheumatol Suppl ; 89: 90-3, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22751603

ABSTRACT

OBJECTIVE: To assess longer-term outcomes, including enthesitis and dactylitis, in patients with active psoriatic arthritis (PsA), in a study of golimumab treatment. METHODS: Adult patients with active PsA were randomized to receive subcutaneous injections of placebo (n = 113), golimumab 50 mg (n = 146), or golimumab 100 mg (n = 146) every 4 weeks through Week 20. All patients received golimumab 50 mg or 100 mg from Week 24 onward. Entheses tenderness was scored in 15 body sites using the PsA-modified Maastricht Ankylosing Spondylitis Enthesitis Score (MASES). Dactylitis was assessed in 20 digits of the hands and feet. RESULTS: Among the 405 randomized patients, 77% presented with enthesitis and 34% dactylitis at baseline. At Week 24 of the placebo-controlled study phase, significant differences were observed between golimumab 50 mg and/or 100 mg and placebo for mean percent improvement in the PsA-modified MASES [46% (p < 0.001) and 52% (p < 0.001) vs 13%, respectively] and the dactylitis score [66% (p = 0.09) and 82% (p < 0.001) vs 28%, respectively]. By Week 52, improvements were maintained among patients randomized to receive golimumab (mean improvements of 54% for PsA-modified MASES and 77% for the dactylitis score). Those given placebo who had enthesitis or dactylitis at baseline and who crossed over to golimumab at Week 16 or 24 had somewhat less improvement at Week 52 (i.e., 39% for the PsA-modified MASES, 57% for dactylitis score). CONCLUSION: Treatment of PsA patients with the TNF inhibitor golimumab was effective across all components of disease, including enthesitis and dactylitis, and efficacy was maintained over longer-term followup.


Subject(s)
Anti-Inflammatory Agents/therapeutic use , Antibodies, Monoclonal/therapeutic use , Arthritis, Psoriatic/drug therapy , Foot Deformities, Acquired/drug therapy , Hand Deformities, Acquired/drug therapy , Joints/drug effects , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Adult , Anti-Inflammatory Agents/administration & dosage , Antibodies, Monoclonal/administration & dosage , Arthritis, Psoriatic/diagnosis , Arthritis, Psoriatic/immunology , Canada , Cross-Over Studies , Double-Blind Method , Europe , Female , Foot Deformities, Acquired/diagnosis , Foot Deformities, Acquired/immunology , Hand Deformities, Acquired/diagnosis , Hand Deformities, Acquired/immunology , Humans , Injections, Subcutaneous , Joints/pathology , Male , Middle Aged , Placebos , Severity of Illness Index , Time Factors , Treatment Outcome , Tumor Necrosis Factor-alpha/metabolism , United States
7.
Lupus ; 17(9): 837-41, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18755866

ABSTRACT

We describe a female Japanese patient with concomitant hypocomplementemic urticarial vasculitis, Jaccoud's arthropathy and valvular heart disease. In 1996, she developed arthritis with swelling of both proximal interphalangeal joints and urticarial vasculitis on both arms that was resolved by administration of glucocorticoid (prednisolone 30 mg/day). Tests for antineutrophil cytoplasmic antibodies, antinuclear antibody and rheumatoid factor gave negative results. The findings of a skin biopsy examination were consistent with 'leukocytoclastic vasculitis'. During 10 years of observation, the patient manifested polyarthritis leading to progressive deformity of the joints of the hands and feet (without loss of cartilage or erosion of bone), persistent urticaria exacerbated by cold and accompanied by hypocomplementemia and progressive cardiac valvular disease with mitral valve regurgitation. There are only three reports described previously documenting five patients with this rare combination of manifestations.


Subject(s)
Complement System Proteins/deficiency , Joint Diseases/complications , Mitral Valve Insufficiency/complications , Urticaria/complications , Vasculitis, Leukocytoclastic, Cutaneous/complications , Adult , Anti-Inflammatory Agents/therapeutic use , Drug Therapy, Combination , Female , Finger Joint/diagnostic imaging , Finger Joint/immunology , Hand Deformities, Acquired/complications , Hand Deformities, Acquired/diagnostic imaging , Hand Deformities, Acquired/immunology , Histamine Antagonists/therapeutic use , Humans , Immunosuppressive Agents/therapeutic use , Joint Diseases/drug therapy , Joint Diseases/immunology , Methotrexate/therapeutic use , Mitral Valve Insufficiency/immunology , Mitral Valve Insufficiency/surgery , Prednisolone/therapeutic use , Radiography , Ribonucleosides/therapeutic use , Urticaria/drug therapy , Urticaria/immunology , Vasculitis, Leukocytoclastic, Cutaneous/drug therapy , Vasculitis, Leukocytoclastic, Cutaneous/immunology
8.
Lupus ; 17(4): 300-4, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18413411

ABSTRACT

The objective was to study the association of antibodies against cyclic citrullinated peptides (anti-CCP) in patients with lupus articular damage. We studied 34 systemic lupus erythematosus patients (30 women) with (n = 14) or without (n = 20) deforming arthropathy. Anti-DNA and arthritis were mandatory inclusion criteria for both groups. As controls, 34 patients with rheumatoid arthritis and nine patients with rheumatoid arthritis and systemic lupus erythematosus (rhupus) were included. Anti-CCP and rheumatoid factor were determined by ELISA and nephelometry respectively. All patients had recent x-ray films of the hands that were evaluated according to Sharp's method. Systemic lupus erythematosus patients had a mean 6.50 +/- 0.86 (SD, range 5-8) American College of Rheumatology (ACR) criteria, rheumatoid arthritis patients met 5.38 +/- 0.60 (range 4-6) ACR criteria for rheumatoid arthritis and rhupus patients had 5.78 +/- 0.44 (range 5-6) criteria for rheumatoid arthritis and 5.11 +/- 0.78 (range 4-6) for systemic lupus erythematosus. Systemic lupus erythematosus patients, with or without deforming arthropathy, had normal serum anti-CCP concentrations. In contrast, rheumatoid arthritis and rhupus patients had 30- and 23-fold higher than normal amounts of anti-CCP (p < 0.001, both comparisons). Rheumatoid arthritis (97%) and rhupus (100%) patients were more frequently positive for anti-CCP than SLE patients with (7%) or without (5%) deforming arthropathy (p < 0.001, both comparisons). Patients with lupus deforming arthropathy were more frequently positive for rheumatoid factor (65%) than patients with non-deforming arthritis (15%) (p = 0.005). Patients with lupus deforming arthropathy had similar frequency of erosions and mean Sharp's score than rhupus patients. Anti-CCP antibodies do not associate with lupus arthropathy, whether deforming, non-deforming or erosive.


Subject(s)
Antibodies/immunology , Arthritis, Rheumatoid/immunology , Hand Deformities, Acquired/immunology , Lupus Erythematosus, Systemic/immunology , Peptides, Cyclic/immunology , Adult , Aged , Aged, 80 and over , Arthritis, Rheumatoid/complications , Arthritis, Rheumatoid/diagnosis , Diagnosis, Differential , Enzyme-Linked Immunosorbent Assay , Female , Follow-Up Studies , Hand Deformities, Acquired/diagnosis , Hand Deformities, Acquired/etiology , Humans , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/diagnosis , Male , Middle Aged , Rheumatoid Factor/metabolism
9.
Int J Lepr Other Mycobact Dis ; 67(3): 250-8, 1999 Sep.
Article in English | MEDLINE | ID: mdl-10575404

ABSTRACT

A vaccine based on autoclaved Mycobacterium w was administered, in addition to standard multidrug therapy (MDT), to 157 bacteriologically positive, lepromin-negative, multibacillary leprosy patients supported by a well-matched control group of 147 patients with similar type of disease who received a placebo injection in addition to MDT. The MDT was given for a minimum period of 2 years and continued until skin-smear negativity, while the vaccine/placebo was given at 3-month intervals up to a maximum of 8 doses in the initial 2 years. The overall incidence of type 1 and type 2 reactions and neuritis during treatment and follow up was nearly equal in the patients in the vaccine and placebo groups; the differences were not statistically significant. The occurrence of disabilities, such as anesthesia, trophic ulcers, claw hand and grade 3 deformities, were not different statistically in the vaccine and placebo groups, an observation valid both for deformities present at induction and for those which developed during the course of therapy and surveillance. A statistically significant difference was observed in the recovery of newly developed trophic ulcers; recovery was quicker in the vaccine group. The recovery rate for motor deformities was marginally higher in the vaccine group, although not significant (p = 0.068) statistically. There was a statistically significant reduction in the incidence of grade 3 deformities following MDT with and without immunotherapy. To conclude, the addition of vaccine to MDT did not precipitate neuritis or deformities over and above that encountered with MDT alone, although it did accelerate bacteriological clearance, histopathological upgrading, conversion to lepromin positivity, and clinical improvement.


Subject(s)
Bacterial Vaccines/therapeutic use , Disabled Persons/statistics & numerical data , Leprostatic Agents/therapeutic use , Leprosy/drug therapy , Mycobacterium leprae/immunology , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Bacterial Vaccines/administration & dosage , Bacterial Vaccines/immunology , Clofazimine/therapeutic use , Double-Blind Method , Drug Therapy, Combination , Hand Deformities, Acquired/epidemiology , Hand Deformities, Acquired/immunology , Hand Deformities, Acquired/prevention & control , Humans , Immunotherapy/methods , Incidence , Leprosy/complications , Leprosy/immunology , Mycobacterium leprae/pathogenicity , Neuritis/epidemiology , Neuritis/prevention & control , Prednisolone/therapeutic use , Ulcer/drug therapy , Ulcer/epidemiology , Ulcer/immunology , Virulence
10.
Lupus ; 3(5): 419-22, 1994 Oct.
Article in English | MEDLINE | ID: mdl-7841997

ABSTRACT

Thirteen patients with systemic lupus erythematosus and deforming arthropathy (DA) of the hands were compared with 111 patients with SLE without deforming arthropathy. Clinical features were comparable in the two groups. Patients fulfilling criteria for mixed connective tissue disease (MCTD) were not included in the present study. A higher prevalence of antibodies to SSA/Ro (P < 0.0125) and SSB/La (P < 0.004) were found in the SLE-DA group. The detection of antibodies to SSA/Ro and SSB/La was even more strictly associated with DA in SLE antibodies to SSA/Ro alone (P < 0.002). Regarding the fine specificity of anti-SSA/Ro, a prevalent response to the 52 kD protein of the Ro antigen was found. We conclude that patients with SLE developing deformities of the hands belong to a subset of patients with circulating antibodies to SSA/Ro, particularly to the 52 kD component, and to SSB/La.


Subject(s)
Antibodies, Antinuclear/physiology , Hand Deformities, Acquired/etiology , Joint Diseases/etiology , Lupus Erythematosus, Systemic/complications , Adolescent , Adult , Aged , Antibodies, Antinuclear/analysis , Antibodies, Antinuclear/immunology , Child , Female , Hand Deformities, Acquired/immunology , Hand Deformities, Acquired/pathology , Humans , Immunoblotting , Joint Diseases/immunology , Joint Diseases/pathology , Lupus Erythematosus, Systemic/immunology , Male , Middle Aged
11.
Clin Rheumatol ; 8(3): 381-5, 1989 Sep.
Article in English | MEDLINE | ID: mdl-2805613

ABSTRACT

We describe a 63-year-old female who developed the CREST syndrome within two years. Even though she was anticentromere antibody positive, her illness followed a very aggressive course and was associated with severe polyarthritis, renal impairment, hypocomplementaemia and mixed cryoglobulinaemia.


Subject(s)
Antibodies, Antinuclear/analysis , Arthritis/complications , Calcinosis/immunology , Centromere/immunology , Chromosomes/immunology , Cryoglobulinemia/complications , Esophageal Motility Disorders/immunology , Hand Deformities, Acquired/immunology , Raynaud Disease/immunology , Telangiectasis/immunology , Acute Disease , Arthritis/immunology , Cryoglobulinemia/immunology , Female , Humans , Middle Aged , Syndrome
12.
J Rheumatol ; 15(1): 65-9, 1988 Jan.
Article in English | MEDLINE | ID: mdl-3258386

ABSTRACT

Forty-one of 858 patients with systemic lupus erythematosus (SLE) developed clinical deformity of their hands. This deformity was clinically and radiologically different from that found in 40 patients with classical or definite rheumatoid arthritis (RA), and tended to appear early in the course of disease. Characteristics of this arthropathy included nonerosive carpal collapse; exceptional erosion of the styloid processes; Z deformity of the thumb; nonerosive ulnar deviation and subluxation of MCP joints; parametacarpophalangeal joint hook formation; scant and asymmetric joint erosions; and swan neck deformity of the fingers. Most of these changes seemed to be due to involvement of the ligaments rather than to the destructive effect of synovitis. Patients with SLE with deforming arthropathy had a higher frequency of rheumatoid factor positivity, sicca symptoms and antibodies to native DNA, whereas they had lower incidence of facial rash and photosensitivity than did those without. Other manifestations did not differ. We propose that most patients with SLE with deforming arthropathy belong to a subset of SLE rather than representing the coexistence of SLE and RA.


Subject(s)
Hand Deformities, Acquired/etiology , Joint Diseases/etiology , Lupus Erythematosus, Systemic/complications , Adolescent , Adult , Aged , Antibodies, Antinuclear/analysis , Arthritis, Rheumatoid , Female , Hand Deformities, Acquired/diagnostic imaging , Hand Deformities, Acquired/immunology , Humans , Joint Diseases/diagnostic imaging , Joint Diseases/immunology , Male , Metacarpophalangeal Joint/diagnostic imaging , Metacarpophalangeal Joint/pathology , Middle Aged , Radiography , Rheumatoid Factor/analysis
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