ABSTRACT
BACKGROUND: Headache is as old as human history and has been able to report, and the first descriptions were found in Greece and Mesopotamia. OBJECTIVE: Our objective was to know the date of the first description of ICHD-3 headaches, with their respective author. METHODS: We searched for articles that addressed the historical aspects of primary and secondary headaches and painful cranial neuropathies. RESULTS: Twenty-seven different headaches were analyzed according to the occurrence of their first description, with the respective author and country of origin. CONCLUSIONS: The knowledge of the first description of ICHD-3 headaches, with their respective author, showed us how and when the different headaches appeared over the years.
Subject(s)
Cranial Nerve Diseases/history , Headache Disorders, Primary/history , Headache Disorders, Secondary/history , Headache/history , Neuralgia/history , Cranial Nerve Diseases/classification , Headache/classification , Headache Disorders, Primary/classification , Headache Disorders, Secondary/classification , History, 17th Century , History, 19th Century , History, 20th Century , History, Ancient , History, Medieval , Humans , Neuralgia/classificationABSTRACT
Nitroglycerin (NTG) (glyceryl trinitrate) was synthesized by the Italian chemist Ascanio Sobrero in Paris in 1846. A very unstable explosive, Alfred Nobel while working on explosives, combined it with Kiselguhr and patented it as dynamite in 1867. NTG was introduced in 1879 in medicine in the treatment of angina pectoris by the English doctor William Murrell. NTG-induced headache was quickly recognized as an important adverse event both in the industrial use of NTG, where it was used to produce dynamite, as well as in the use of NTG as drug. This review traces the evolution of our understanding of NTG headache.
Subject(s)
Headache Disorders, Primary/chemically induced , Headache Disorders, Primary/history , Nitroglycerin/adverse effects , Vasodilator Agents/adverse effects , History, 19th Century , History, 20th Century , History, 21st Century , HumansABSTRACT
Over the past two decades, the development of new functional neuroimaging techniques has improved our understanding of the brain events underlying several primary headache disorders. In migraine and cluster headache, the advent of these techniques has shifted the emphasis in pathophysiological research away from the vessel and back to the brain.
