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1.
J Vet Med Sci ; 86(4): 381-388, 2024 Apr 01.
Article in English | MEDLINE | ID: mdl-38369331

ABSTRACT

Sensorineural hearing loss (SNHL) induced by noise has increased in recent years due to personal headphone use and noisy urban environments. The study shows a novel model of gradually progressive SNHL induced by repeated exposure to moderate noise (8-kHz octave band noise, 90-dB sound pressure level) for 1 hr exposure per day in BALB/cCr mice. The results showed that the repeated exposure led to gradually progressive SNHL, which was dependent on the number of exposures, and resulted in permanent hearing loss after 5 exposures. Repeated exposure to noise causes a loss of synapses between the inner hair cells and the peripheral terminals of the auditory nerve fibers. Additionally, there is a reduction in the expression levels of c-fos and Arc, both of which are indicators of cochlear nerve responses to noise exposure. Oral administration of resveratrol (RSV, 50 mg/kg/day) during the noise exposure period significantly prevented the noise exposure-induced synapse loss and SNHL. Furthermore, the study found that RSV treatment prevented the noise-induced increase in the gene expression levels of the proinflammatory cytokine interleukin-1ß in the cochlea. These results demonstrated the potential usefulness of RSV in preventing noise-induced SNHL in the animal model established as gradually progressive SNHL.


Subject(s)
Hearing Loss, Noise-Induced , Hearing Loss, Sensorineural , Rodent Diseases , Mice , Animals , Resveratrol/therapeutic use , Noise/adverse effects , Hearing Loss, Sensorineural/prevention & control , Hearing Loss, Sensorineural/complications , Hearing Loss, Sensorineural/veterinary , Hearing Loss, Noise-Induced/prevention & control , Hearing Loss, Noise-Induced/etiology , Hearing Loss, Noise-Induced/veterinary , Cochlea
2.
J Acoust Soc Am ; 151(6): 4252, 2022 06.
Article in English | MEDLINE | ID: mdl-35778178

ABSTRACT

Intense sound sources, such as pile driving, airguns, and military sonars, have the potential to inflict hearing loss in marine mammals and are, therefore, regulated in many countries. The most recent criteria for noise induced hearing loss are based on empirical data collected until 2015 and recommend frequency-weighted and species group-specific thresholds to predict the onset of temporary threshold shift (TTS). Here, evidence made available after 2015 in light of the current criteria for two functional hearing groups is reviewed. For impulsive sounds (from pile driving and air guns), there is strong support for the current threshold for very high frequency cetaceans, including harbor porpoises (Phocoena phocoena). Less strong support also exists for the threshold for phocid seals in water, including harbor seals (Phoca vitulina). For non-impulsive sounds, there is good correspondence between exposure functions and empirical thresholds below 10 kHz for porpoises (applicable to assessment and regulation of military sonars) and between 3 and 16 kHz for seals. Above 10 kHz for porpoises and outside of the range 3-16 kHz for seals, there are substantial differences (up to 35 dB) between the predicted thresholds for TTS and empirical results. These discrepancies call for further studies.


Subject(s)
Hearing Loss, Noise-Induced , Phoca , Phocoena , Acoustic Stimulation , Animals , Auditory Fatigue , Hearing Loss, Noise-Induced/diagnosis , Hearing Loss, Noise-Induced/etiology , Hearing Loss, Noise-Induced/veterinary , Noise/adverse effects , Phocoena/physiology , Psychoacoustics , Sound Spectrography
3.
Top Companion Anim Med ; 37: 100362, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31837756

ABSTRACT

Three working dogs were diagnosed with noise-induced hearing loss following exposure to loud noise. Physical and neurologic examinations in each case revealed no significant findings. Brainstem auditory evoked response (BAER) demonstrated bilateral sensorineural deafness. One dog did not regain hearing but continued working with adjusted protocols utilizing hand signals. One dog was lost to follow-up. The last dog was treated with oral Vitamin B complex (daily), Vitamin E (400 IU daily), and N-acetyl-cystine (600 mg daily) and regained hearing 2 months later, based on repeat BAER testing.


Subject(s)
Dog Diseases/etiology , Hearing Loss, Noise-Induced/veterinary , Noise/adverse effects , Animals , Cystine/analogs & derivatives , Cystine/therapeutic use , Dog Diseases/drug therapy , Dogs , Evoked Potentials, Auditory, Brain Stem , Female , Firearms , Hearing Loss, Noise-Induced/drug therapy , Housing, Animal , Male , Vitamin B Complex/therapeutic use , Vitamin E/therapeutic use
4.
J Acoust Soc Am ; 138(3): 1702-26, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26428808

ABSTRACT

One of the most widely recognized effects of intense noise exposure is a noise-induced threshold shift­an elevation of hearing thresholds following cessation of the noise. Over the past twenty years, as concerns over the potential effects of human-generated noise on marine mammals have increased, a number of studies have been conducted to investigate noise-induced threshold shift phenomena in marine mammals. The experiments have focused on measuring temporary threshold shift (TTS)­a noise-induced threshold shift that fully recovers over time­in marine mammals exposed to intense tones, band-limited noise, and underwater impulses with various sound pressure levels, frequencies, durations, and temporal patterns. In this review, the methods employed by the groups conducting marine mammal TTS experiments are described and the relationships between the experimental conditions, the noise exposure parameters, and the observed TTS are summarized. An attempt has been made to synthesize the major findings across experiments to provide the current state of knowledge for the effects of noise on marine mammal hearing.


Subject(s)
Caniformia/physiology , Cetacea/physiology , Hearing Loss, Noise-Induced/veterinary , Animals , Auditory Fatigue/physiology , Auditory Threshold/physiology , Environmental Exposure , Female , Hearing Loss, Noise-Induced/etiology , Male , Noise , Sound
5.
Article in English | MEDLINE | ID: mdl-23850719

ABSTRACT

Impulsive pile driving sound can cause injury to fishes, but no studies to date have examined whether such injuries include damage to sensory hair cells in the ear. Possible effects on hair cells were tested using a specially designed wave tube to expose two species, hybrid striped bass (white bass Morone chrysops × striped bass Morone saxatilis) and Mozambique tilapia (Oreochromis mossambicus), to pile driving sounds. Fish were exposed to 960 pile driving strikes at one of three treatment levels: 216, 213, or 210dB re 1 µPa(2)·s cumulative Sound Exposure Level. Both hybrid striped bass and tilapia exhibited barotraumas such as swim bladder ruptures, herniations, and hematomas to several organs. Hybrid striped bass exposed to the highest sound level had significant numbers of damaged hair cells, while no damage was found when fish were exposed at lower sound levels. Considerable hair cell damage was found in only one out of 11 tilapia specimens exposed at the highest sound level. Results suggest that impulsive sounds such as from pile driving may have a more significant effect on the swim bladders and surrounding organs than on the inner ears of fishes, at least at the sound exposure levels used in this study.


Subject(s)
Ear, Inner/injuries , Fish Diseases/etiology , Hearing Loss, Noise-Induced/veterinary , Noise/adverse effects , Animals , Bass , Construction Industry , Ear, Inner/pathology , Environmental Exposure , Fish Diseases/pathology , Hair Cells, Auditory/pathology , Hearing Loss, Noise-Induced/etiology , Hearing Loss, Noise-Induced/pathology , Oceans and Seas , Tilapia
6.
Vet Clin North Am Small Anim Pract ; 42(6): 1209-24, 2012 Nov.
Article in English | MEDLINE | ID: mdl-23122177

ABSTRACT

Conductive deafness, caused by outer or middle ear obstruction, may be corrected, whereas sensorineural deafness cannot. Most deafness in dogs is congenital sensorineural hereditary deafness, associated with the genes for white pigment: piebald or merle. The genetic cause has not yet been identified. Dogs with blue eyes have a greater likelihood of hereditary deafness than brown-eyed dogs. Other common forms of sensorineural deafness include presbycusis, ototoxicity, noise-induced hearing loss, otitis interna, and anesthesia. Definitive diagnosis of deafness requires brainstem auditory evoked response testing.


Subject(s)
Deafness/veterinary , Dog Diseases/diagnosis , Ear Diseases/veterinary , Animals , Deafness/diagnosis , Deafness/etiology , Deafness/genetics , Dog Diseases/etiology , Dog Diseases/genetics , Dogs , Ear Diseases/complications , Ear Diseases/diagnosis , Ear Diseases/genetics , Hearing Loss, Noise-Induced/diagnosis , Hearing Loss, Noise-Induced/veterinary , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sensorineural/etiology , Hearing Loss, Sensorineural/genetics , Hearing Loss, Sensorineural/veterinary , Presbycusis/diagnosis , Presbycusis/veterinary
7.
Am J Vet Res ; 73(4): 482-9, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22452494

ABSTRACT

OBJECTIVE: To evaluate the degree of noise to which kenneled dogs were exposed in 2 typical kennels and to determine whether a measurable change in hearing might have developed as a result of exposure to this noise. ANIMALS: 14 dogs temporarily housed in 2 kennel environments. PROCEDURES: Noise levels were measured for a 6-month period in one environment (veterinary technical college kennel) and for 3 months in another (animal shelter). Auditory brainstem response testing was performed on dogs in the veterinary kennel 48 hours and 3 and 6 months after arrival. Temporal changes in the lowest detectable response levels for wave V were analyzed. RESULTS: Acoustic analysis of the kennel environments revealed equivalent sound level values ranging between 100 and 108 dB sound pressure level for the 2 kennels. At the end of 6 months, all 14 dogs that underwent hearing tests had a measured change in hearing. CONCLUSIONS AND CLINICAL RELEVANCE: Results of the noise assessments indicated levels that are damaging to the human auditory system. Such levels could be considered dangerous for kenneled dogs as well, particularly given the demonstrated hearing loss in dogs housed in the veterinary kennel for a prolonged period. Noise abatement strategies should be a standard part of kennel design and operation when such kennels are intended for long-term housing of dogs.


Subject(s)
Dog Diseases/etiology , Hearing Loss, Noise-Induced/veterinary , Housing, Animal/standards , Noise/adverse effects , Animal Welfare , Animals , Dogs , Evoked Potentials, Auditory, Brain Stem , Hearing Loss, Noise-Induced/etiology
9.
J Acoust Soc Am ; 129(1): 496-506, 2011 Jan.
Article in English | MEDLINE | ID: mdl-21303030

ABSTRACT

The potential for seismic airgun "shots" to cause acoustic trauma in marine mammals is poorly understood. There are just two empirical measurements of temporary threshold shift (TTS) onset levels from airgun-like sounds in odontocetes. Considering these limited data, a model was developed examining the impact of individual variability and uncertainty on risk assessment of baleen whale TTS from seismic surveys. In each of 100 simulations: 10000 "whales" are assigned TTS onset levels accounting for: inter-individual variation; uncertainty over the population's mean; and uncertainty over weighting of odontocete data to obtain baleen whale onset levels. Randomly distributed whales are exposed to one seismic survey passage with cumulative exposure level calculated. In the base scenario, 29% of whales (5th/95th percentiles of 10%/62%) approached to 1-1.2 km range were exposed to levels sufficient for TTS onset. By comparison, no whales are at risk outside 0.6 km when uncertainty and variability are not considered. Potentially "exposure altering" parameters (movement, avoidance, surfacing, and effective quiet) were also simulated. Until more research refines model inputs, the results suggest a reasonable likelihood that whales at a kilometer or more from seismic surveys could potentially be susceptible to TTS and demonstrate that the large impact uncertainty and variability can have on risk assessment.


Subject(s)
Acoustics , Geology , Hearing Loss, Noise-Induced/veterinary , Models, Statistical , Noise/adverse effects , Uncertainty , Whales , Animals , Computer Simulation , Hearing Loss, Noise-Induced/etiology , Risk Assessment , Risk Factors
10.
J Acoust Soc Am ; 128(2): 567-70, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20707425

ABSTRACT

Temporary threshold shift (TTS) was measured in a bottlenose dolphin (Tursiops truncatus) after exposure to 16-s tones at 3 and 20 kHz to examine the effects of exposure frequency on the onset and growth of TTS. Thresholds were measured approximately one-half octave above the exposure frequency using a behavioral response paradigm featuring an adaptive staircase procedure. Preliminary data provide evidence of frequency-specific differences in TTS onset and growth, and increased susceptibility to auditory fatigue after exposure to 3-kHz tones compared to data obtained two years earlier.


Subject(s)
Auditory Threshold , Bottle-Nosed Dolphin , Hearing Loss, Noise-Induced/veterinary , Noise/adverse effects , Acoustic Stimulation/veterinary , Animals , Female , Hearing Loss, Noise-Induced/etiology , Hearing Loss, Noise-Induced/physiopathology , Hearing Tests/veterinary , Time Factors
11.
J Am Assoc Lab Anim Sci ; 46(1): 23-7, 2007 Jan.
Article in English | MEDLINE | ID: mdl-17203912

ABSTRACT

The auditory system of rodents and other animals is affected by numerous genetic and environmental variables. These include genes that cause hearing loss, exposure to noise that induces hearing loss, ameliorative effects of an augmented acoustic environment on hearing loss, and effects of background noise on arousal. An understanding of genetic and environmental influences on hearing and auditory behavior is important for those who provide, use, and care for laboratory animals.


Subject(s)
Animals, Laboratory/physiology , Auditory Perception/physiology , Hearing/physiology , Mice/physiology , Rats/physiology , Animals , Cochlear Nucleus/chemistry , Electron Transport Complex IV/analysis , Environment , Hearing/genetics , Hearing Loss/genetics , Hearing Loss/veterinary , Hearing Loss, Noise-Induced/veterinary , Noise , Rodent Diseases/genetics
12.
Lab Anim Sci ; 30(2 Pt 2): 422-39, 1980 Apr.
Article in English | MEDLINE | ID: mdl-7052388

ABSTRACT

The preponderance of experimental evidence gathered over the past three decades indicates that exposure to intense noise can lead to a wide variety of functional and structural changes in laboratory animals. Although little information regarding noise effects at more moderate levels is available, the range of intensities at which such effects begin to be manifested in humans seems to be present in animal quarters. Fortunately, there is an assortment of techniques for reducing the noise exposure of both animals and animal care personnel. Because of serious deficiencies in our knowledge concerning actual long-term noise levels in animal housing facilities and the ways in which such noise affects different species, the imposition at this time of quantitative regulations governing exposure limits for laboratory animals would be premature.


Subject(s)
Animal Husbandry , Animals, Laboratory/physiology , Housing, Animal , Noise/adverse effects , Animals , Blood Pressure , Endocrine Glands/physiology , Hearing Loss, Noise-Induced/veterinary , Heart Rate , Legislation, Veterinary , Macaca mulatta/physiology , Noise/prevention & control
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