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4.
Article in English | MEDLINE | ID: mdl-37573256

ABSTRACT

OBJECTIVE: To report the prevalence of initial shockable cardiac arrest rhythms (I-SHKR), incidence of subsequent shockable cardiac arrest rhythms (S-SHKR), and factors associated with I-SHKRs and S-SHKRs and explore their association with return of spontaneous circulation (ROSC) rates in dogs and cats undergoing CPR. DESIGN: Multi-institutional prospective case series from 2016 to 2021, retrospectively analyzed. SETTING: Eight university and eight private practice veterinary hospitals. ANIMALS: A total of 457 dogs and 170 cats with recorded cardiac arrest rhythm and event outcome reported in the Reassessment Campaign on Veterinary Resuscitation CPR registry. MEASUREMENTS AND MAIN RESULTS: Logistic regression was used to evaluate association of animal, hospital, and arrest variables with I-SHKRs and S-SHKRs and with patient outcomes. Odds ratios (ORs) were generated, and significance was set at P < 0.05. Of 627 animals included, 28 (4%) had I-SHKRs. Odds for I-SHKRs were significantly higher in animals with a metabolic cause of arrest (OR 7.61) and that received lidocaine (OR 17.50) or amiodarone (OR 21.22) and significantly lower in animals experiencing arrest during daytime hours (OR 0.22), in the ICU (OR 0.27), in the emergency room (OR 0.13), and out of hospital (OR 0.18) and that received epinephrine (OR 0.19). Of 599 initial nonshockable rhythms, 74 (12%) developed S-SHKRs. Odds for S-SHKRs were significantly higher in animals with higher body weight (OR 1.03), hemorrhage (OR 2.85), or intracranial cause of arrest (OR 3.73) and that received epinephrine (OR 11.36) or lidocaine (OR 18.72) and significantly decreased in those arresting in ICU (OR 0.27), emergency room (OR 0.29), and out of hospital (OR 0.38). Overall, 171 (27%) animals achieved ROSC, 81 (13%) achieved sustained ROSC, and 15 (2%) survived. Neither I-SHKRs nor S-SHKRs were significantly associated with ROSC. CONCLUSIONS: I-SHKRs and S-SHKRs occur infrequently in dogs and cats undergoing CPR and are not associated with increased ROSC rates.


Subject(s)
Cardiopulmonary Resuscitation , Cat Diseases , Dog Diseases , Emergency Medical Services , Heart Arrest , Humans , Cats , Dogs , Animals , Cardiopulmonary Resuscitation/veterinary , Retrospective Studies , Prevalence , Cat Diseases/epidemiology , Cat Diseases/therapy , Dog Diseases/epidemiology , Dog Diseases/therapy , Epinephrine , Lidocaine , Heart Arrest/epidemiology , Heart Arrest/therapy , Heart Arrest/veterinary , Registries
5.
Vet Clin North Am Exot Anim Pract ; 26(3): 737-750, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37516461

ABSTRACT

Evidence-based recommendations for performing cardiopulmonary resuscitation (CPR) in domestic species provide a foundation for application to nondomestic species. The exotic and zoo practitioner must consider human safety, species anatomy, physiology, and special techniques for performing CPR. Having the hospital and team prepared and trained for a CPR response can improve outcomes. Basic life support includes various techniques for chest compressions and ventilation support. Advanced life support includes means of intravascular and intraosseous access, rescue drug administration, and consideration of the patient presenting circumstances. Team debriefs and support for mental wellness are useful to optimize performance and maintain team resiliency through CPR events.


Subject(s)
Animals, Exotic , Cardiopulmonary Resuscitation , Heart Arrest , Humans , Animals , Cardiopulmonary Resuscitation/veterinary , Cardiopulmonary Resuscitation/methods , Heart Arrest/veterinary , Critical Care
6.
J Vet Sci ; 24(3): e47, 2023 May.
Article in English | MEDLINE | ID: mdl-37271514

ABSTRACT

Del-Nido cardioplegia (DNc) is a single-dose cardioplegia that is widely used in human medicine because of its long duration. In this report, we describe two cases of open-heart surgery with cardiopulmonary bypass (CPB) using DNc. One dog was diagnosed with partial atrioventricular septal defect, and the other dog was diagnosed with myxomatous mitral valve disease stage D. Both dogs were treated with open-heart surgery with DNc to induce temporary cardiac arrest. No complications from DNc were observed, and the patients were discharged. Veterinary heart surgeons should consider DNc as an option for temporary cardiac arrest during open-heart surgery with CPB.


Subject(s)
Cardiac Surgical Procedures , Dog Diseases , Heart Arrest , Humans , Dogs , Animals , Cardioplegic Solutions , Heart Arrest, Induced/veterinary , Cardiac Surgical Procedures/veterinary , Heart Arrest/veterinary , Retrospective Studies , Dog Diseases/surgery
7.
J Vet Intern Med ; 37(4): 1428-1437, 2023.
Article in English | MEDLINE | ID: mdl-37316975

ABSTRACT

BACKGROUND: Global hypoxic-ischemic brain injury (GHIBI) results in variable degrees of neurological dysfunction. Limited data exists to guide prognostication on likelihood of functional recovery. HYPOTHESIS: Prolonged duration of hypoxic-ischemic insult and absence of neurological improvement in the first 72 hours are negative prognostic indicators. ANIMALS: Ten clinical cases with GHIBI. METHODS: Retrospective case series describing 8 dogs and 2 cats with GHIBI, including clinical signs, treatment, and outcome. RESULTS: Six dogs and 2 cats experienced cardiopulmonary arrest or anesthetic complication in a veterinary hospital and were promptly resuscitated. Seven showed progressive neurological improvement within 72 hours of the hypoxic-ischemic insult. Four fully recovered and 3 had residual neurological deficits. One dog presented comatose after resuscitation at the primary care practice. Magnetic resonance imaging confirmed diffuse cerebral cortical swelling and severe brainstem compression and the dog was euthanized. Two dogs suffered out-of-hospital cardiopulmonary arrest, secondary to a road traffic accident in 1 and laryngeal obstruction in the other. The first dog was euthanized after MRI that identified diffuse cerebral cortical swelling with severe brainstem compression. In the other dog, spontaneous circulation was recovered after 22 minutes of cardiopulmonary resuscitation. However, the dog remained blind, disorientated, and ambulatory tetraparetic with vestibular ataxia and was euthanized 58 days after presentation. Histopathological examination of the brain confirmed severe diffuse cerebral and cerebellar cortical necrosis. CONCLUSIONS AND CLINICAL IMPORTANCE: Duration of hypoxic-ischemic insult, diffuse brainstem involvement, MRI features, and rate of neurological recovery could provide indications of the likelihood of functional recovery after GHIBI.


Subject(s)
Brain Injuries , Cardiopulmonary Resuscitation , Dog Diseases , Heart Arrest , Dogs , Animals , Retrospective Studies , Cardiopulmonary Resuscitation/veterinary , Heart Arrest/therapy , Heart Arrest/veterinary , Brain/pathology , Brain Injuries/pathology , Brain Injuries/veterinary , Dog Diseases/diagnosis , Dog Diseases/therapy , Dog Diseases/pathology
8.
Article in English | MEDLINE | ID: mdl-36815742

ABSTRACT

OBJECTIVE: To describe the clinical signs, electroencephalographic (EEG) findings, treatment, and outcome in a dog after successful resuscitation from out-of-hospital cardiopulmonary arrest (OHCA) induced by pentobarbital intoxication. CASE SUMMARY: A 10-year-old, male intact Jack Russell Terrier was referred for management of refractory status epilepticus and presented dead on arrival. After 7 minutes of cardiopulmonary resuscitation, return of spontaneous circulation was achieved, but the dog remained comatose, apneic, and lacked brainstem reflexes on neurological examination 6 hours following resuscitation. Magnetic resonance imaging showed polioencephalomalacia consistent with prolonged epileptiform activity, and EEG was initially concerning for electrocerebral inactivity. Following supportive care that included short-term mechanical ventilation, the dog made a full recovery and was discharged from the hospital alive 7 days postresuscitation. It was later revealed that the dog had been administered an unknown amount of pentobarbital during transportation, which likely contributed to the OHCA, clinical, and EEG findings. NEW INFORMATION PROVIDED: This is the first report to describe the full recovery and hospital discharge of a dog suffering OHCA and the first description of EEG findings in a clinical veterinary patient following cardiopulmonary arrest and successful resuscitation. Factors likely contributing to successful patient outcome and potential benefits and limitations of EEG in monitoring postcardiac arrest patients are discussed.


Subject(s)
Cardiopulmonary Resuscitation , Dog Diseases , Drug Overdose , Heart Arrest , Male , Dogs , Animals , Pentobarbital , Heart Arrest/chemically induced , Heart Arrest/therapy , Heart Arrest/veterinary , Cardiopulmonary Resuscitation/veterinary , Cardiopulmonary Resuscitation/methods , Drug Overdose/veterinary , Hospitals , Dog Diseases/chemically induced , Dog Diseases/therapy
9.
J Vet Emerg Crit Care (San Antonio) ; 33(2): 173-179, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36815755

ABSTRACT

OBJECTIVE: To determine if human automated external defibrillators (AEDs) could successfully record cardiac electrical activity in dogs, make appropriate recommendations regarding shock delivery, and characterize skin preparation required for a readable ECG based on dog haircoat characteristics. DESIGN: Prospective study of AED use in dogs conducted between January and March 2021. SETTING: University teaching hospital. ANIMALS: Three groups of client-owned dogs were evaluated. Group 1 consisted of 23 healthy dogs with sinus rhythms, group 2 consisted of 9 dogs with documented cardiac arrhythmias, and group 3 consisted of 9 dogs receiving CPR following naturally occurring cardiopulmonary arrest. MATERIALS AND METHODS: Haircoat characteristics and clipping or ECG paste required to obtain a readable ECG were recorded. The time interval from a readable ECG by the investigator until AED shock advisement was measured. Correctness of shock advice was recorded. Analyses were performed using commercial statistical software. P-values <0.05 were considered significant. RESULTS: The attending veterinarian judged the ECG on the AED to be readable in all dogs. Time to shock advisement in all dogs was median 18 (range: 7-180) seconds. Dogs with heavy, long, or double haircoats required clipping in 24 of 27 (89%) cases to obtain a readable ECG. ECG paste on the AED pad was required in 36 of 40 dogs (90%) in order to obtain a readable ECG. The AED advice for delivery of shock was appropriate in 51 of 52 (98%) queries of the machine across all groups. CONCLUSIONS: Human AEDs can successfully record cardiac electrical activity in dogs. AEDs appropriately recommend delivery of a shock most times, contingent on skin preparation. Dogs with double, long, or heavy haircoats should be clipped prior to pad application. ECG paste will aid AED reading in all haircoat types. Further investigation is warranted into AED use in dogs, particularly in general practices.


Subject(s)
Cardiopulmonary Resuscitation , Dog Diseases , Heart Arrest , Humans , Dogs , Animals , Prospective Studies , Defibrillators/veterinary , Heart Arrest/veterinary , Arrhythmias, Cardiac/veterinary , Cardiopulmonary Resuscitation/education , Cardiopulmonary Resuscitation/veterinary , Dog Diseases/therapy
10.
J Vet Emerg Crit Care (San Antonio) ; 33(2): 223-235, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36537864

ABSTRACT

OBJECTIVE: To investigate the association of point-of-care biochemical variables obtained during CPR or within 24 hours of return of spontaneous circulation (ROSC) with patient outcomes. DESIGN: Retrospective study. SETTING: University teaching hospital. ANIMALS: Ninety-four dogs and 27 cats undergoing CPR according to the Reassessment Campaign on Veterinary Resuscitation guidelines. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Blood gas, acid-base, electrolyte, glucose, and plasma lactate values obtained during CPR or within 24 hours of ROSC were retrospectively evaluated and are described. The blood sample type and collection time with respect to CPR initiation and ROSC were recorded. Measured variables, collection times, and species were included in a multivariable logistic regression model to estimate the odds ratio (OR) and 95% confidence interval of ROSC, sustained ROSC (≥20 min), and survival to hospital discharge. Significance was set at P < 0.05. Seventy-two venous blood samples obtained during CPR and 45 first venous and arterial blood samples obtained after ROSC were included in logistic regression analysis. During CPR, PvO2 (1.09 [1.036-1.148], P = 0.001) and venous standard base excess (SBE) (1.207 [1.094-1.331], P < 0.001) were associated with ROSC. PvO2 (1.075 [1.028-1.124], P = 0.002), SBE (1.171 [1.013-1.353], P = 0.032), and potassium concentration (0.635 [0.426-0.946], P = 0.026) were associated with sustained ROSC. Potassium concentration (0.235 [0.083-0.667], P = 0.007) was associated with survival to hospital discharge. Following ROSC, pH (69.110 [4.393-1087], P = 0.003), potassium concentration (0.222 [0.071-0.700], P = 0.010), and chloride concentration (0.805 [0.694-0.933], P = 0.004) were associated with survival to hospital discharge. CONCLUSIONS: Biochemical variables such as PvO2 , SBE, and potassium concentration during CPR and pH, potassium, and chloride concentration in the postarrest period may help identify dogs and cats with lower odds for ROSC or survival to hospital discharge following CPR.


Subject(s)
Cardiopulmonary Resuscitation , Cat Diseases , Dog Diseases , Heart Arrest , Cats , Dogs , Animals , Cardiopulmonary Resuscitation/veterinary , Cardiopulmonary Resuscitation/methods , Heart Arrest/therapy , Heart Arrest/veterinary , Retrospective Studies , Return of Spontaneous Circulation , Cat Diseases/therapy , Chlorides , Point-of-Care Systems , Dog Diseases/therapy
11.
J Vet Emerg Crit Care (San Antonio) ; 33(2): 143-155, 2023 Mar.
Article in English | MEDLINE | ID: mdl-36573548

ABSTRACT

OBJECTIVE: To introduce the Reassessment Campaign on Veterinary Resuscitation (RECOVER) CPR registry and report cardiopulmonary arrest (CPA) and CPR event data collected to date. DESIGN: International, multi-institutional veterinary CPR registry data report. SETTING: Veterinary private practice and university teaching hospitals. ANIMALS: Data from 514 dogs and 195 cats undergoing CPR entered in the RECOVER CPR registry between February 2016 and November 2021. INTERVENTIONS: The RECOVER CPR registry is an online medical database created for standardized collection of hospital, animal, arrest, and outcome information on dogs and cats undergoing CPR. Data were collected according to the veterinary Utstein-style guidelines for standardized reporting of in-hospital CPR in dogs and cats. Case records were downloaded, duplicate and incomplete cases were removed, and summary descriptive data were reported. MEASUREMENTS AND MAIN RESULTS: Sixteen hospitals in the United States, Europe, and Australia contributed data on 709 CPR events to the registry. One hundred and forty-two (28%) dogs and 58 (30%) cats attained return of spontaneous circulation (ROSC), 62 (12%) dogs and 25 (13%) cats had ROSC >20 minutes, and 14 (3%) dogs and 4 (2%) cats survived to hospital discharge. The reason for CPR discontinuation was reported as owner choice in 321 cases (63%). The most common suspected causes for CPA were respiratory failure (n = 142, 20%), heart failure (n = 86, 12%), and hemorrhage (n = 76, 11%). CONCLUSION: The RECOVER CPR registry contains the first multicenter data set on small animal CPR. It confirms poor outcomes associated with CPA, emphasizing the need for large-sized studies to gain adequate information on characteristics associated with favorable outcomes.


Subject(s)
Cardiopulmonary Resuscitation , Cat Diseases , Dog Diseases , Heart Arrest , Cats , Animals , Dogs , United States , Cardiopulmonary Resuscitation/veterinary , Cat Diseases/therapy , Dog Diseases/therapy , Heart Arrest/therapy , Heart Arrest/veterinary , Registries , Hospitals, Teaching
12.
J Small Anim Pract ; 64(4): 270-279, 2023 04.
Article in English | MEDLINE | ID: mdl-36562427

ABSTRACT

OBJECTIVES: To describe and compare cardiopulmonary resuscitation outcomes at a Swiss veterinary teaching hospital before and after publication of the Reassessment Campaign on Veterinary Resuscitation guidelines. MATERIALS AND METHODS: Between 2018 and 2020, hospital staff underwent various types of yearly Reassessment Campaign on Veterinary Resuscitation-based cardiopulmonary resuscitation trainings. Canine and feline cardiopulmonary resuscitation events during that period (post-Reassessment Campaign on Veterinary Resuscitation) and between 2010 and 2012 (pre-Reassessment Campaign on Veterinary Resuscitation) were identified and animal, arrest and outcome variables recorded retrospectively. RESULTS: Eighty-one animals were included in the pre-Reassessment Campaign on Veterinary Resuscitation group and 190 in the post-Reassessment Campaign on Veterinary Resuscitation group. Twenty-three percent in the pre-Reassessment Campaign on Veterinary Resuscitation group and 28% in the post-Reassessment Campaign on Veterinary Resuscitation group achieved return of spontaneous circulation and 1% and 4% survived to hospital discharge, respectively. Patients undergoing anaesthesia [odds ratio 4.26 (1.76 to 10.27)], elective [odds ratio 5.16 (1.06 to 25.02)] or emergent surgery [odds ratio 3.09 (1.20 to 8.00)], or experiencing cardiopulmonary arrest (CPA) due to arrhythmias [odds ratio 4.31 (1.44 to 12.93)] had higher odds of return of spontaneous circulation, while those with unknown cause of CPA [odds ratio 0.25 (0.08 to 0.78)] had lower odds. Undergoing cardiopulmonary resuscitation in the post-Reassessment Campaign on Veterinary Resuscitation period was not statistically significantly associated with return of spontaneous circulation [odds ratio 1.38 (0.68 to 2.79)]. CLINICAL SIGNIFICANCE: Unchanged odds of return of spontaneous circulation observed in this study could suggest that once-yearly cardiopulmonary resuscitation training is insufficient, effects of animal and tertiary referral hospital variables confounded results, guideline benefit is limited, or that compliance during clinical cardiopulmonary resuscitation efforts is too poor for guideline recommendations to have a positive impact.


Subject(s)
Cardiopulmonary Resuscitation , Cat Diseases , Dog Diseases , Heart Arrest , Cats , Animals , Dogs , Hospitals, Animal , Cat Diseases/therapy , Retrospective Studies , Hospitals, Teaching , Dog Diseases/therapy , Cardiopulmonary Resuscitation/veterinary , Cardiopulmonary Resuscitation/methods , Heart Arrest/therapy , Heart Arrest/veterinary
13.
Aust Vet J ; 100(9): 433-439, 2022 Sep.
Article in English | MEDLINE | ID: mdl-35656570

ABSTRACT

BACKGROUND: Global brain ischaemia following cardiopulmonary arrest is uncommonly reported in veterinary medicine yet neurologic injury after arrest is a known morbidity. CASE REPORT: An 18-week-old male entire Cavalier King Charles Spaniel-Poodle was referred following 3 days of neurologic abnormalities after cardiopulmonary arrest. After resuscitation, the animal had decerebrate rigidity, a stuporous mentation and intermittent episodes of vocalisation and apnoea. A brain magnetic resonance imaging (MRI) was undertaken 4 days after cardiopulmonary arrest, with standard sequences (T1-weighted, T2-weighted and fluid-attenuated inversion recovery) as well as diffusion-weighted imaging to better discern ischaemic injury and cytotoxic oedema for prognostic reasons. MRI findings were consistent with global brain ischaemia affecting the hippocampus, cerebellum and substantia nigra, the latter two not previously identified in canine cases of global brain ischaemia. The patient was euthanased on day eight post-cardiopulmonary arrest due to a lack of neurological improvement and developing sepsis as a complication. Ante-mortem identification of affected areas of the brain was confirmed on histological examination, with evidence of ischaemic injury seen in the cerebrum, hippocampus, cerebellum, basal nuclei and thalamus. CONCLUSION: This report describes ante-mortem MRI and postmortem findings in a dog with global brain ischaemia following cardiopulmonary arrest. A multimodal approach to neuroprognostication in patients recovering from cardiopulmonary arrest is recommended.


Subject(s)
Brain Ischemia , Dog Diseases , Heart Arrest , Animals , Brain/diagnostic imaging , Brain/pathology , Brain Ischemia/complications , Brain Ischemia/pathology , Brain Ischemia/veterinary , Diffusion Magnetic Resonance Imaging/adverse effects , Diffusion Magnetic Resonance Imaging/methods , Dog Diseases/diagnostic imaging , Dog Diseases/etiology , Dog Diseases/pathology , Dogs , Heart Arrest/veterinary , Magnetic Resonance Imaging/veterinary , Male
14.
BMC Vet Res ; 18(1): 184, 2022 May 16.
Article in English | MEDLINE | ID: mdl-35578237

ABSTRACT

BACKGROUND: Mitral valvuloplasty (MVP) has been widely recognized as a treatment option for myxomatous mitral valve disease (MMVD). However, postoperative complications such as thromboembolism, arrhythmia, and pancreatitis in some cases have resulted in death. We treated a dog with severe MMVD complicated by impaired sinus function with MVP and pacemaker implantation. Also, due to an intrinsic procoagulant state and severe arrhythmia after the MVP, left atrial appendage (LAA) closure was performed to reduce the postoperative risk of thrombosis. CASE PRESENTATION: An 11-year-old castrated 7.5-kg male Miniature Schnauzer with a history of congestive heart failure was brought to Shiraishi Animal Hospital for MMVD surgical treatment. Echocardiography revealed an enlarged left atrium and ventricle secondary to MMVD. Sinus arrest with 2 to 3-second periods of asystole was identified by electrocardiogram. Mitral valvuloplasty was performed with cardiopulmonary bypass to treat the MMVD. After coronary reperfusion, there was no spontaneous electrical activity. Cardiac arrest continued. Based on this surgical outcome, a permanent pacemaker was implanted. In addition, LAA closure with an AtriClip was performed to prevent intra-atrial thrombus formation. Cardiac remodeling and congestion were ameliorated after surgery. Sinus rhythm was restored 5 days postoperatively; however, the patient continued pacemaker dependent. All cardiac drugs were discontinued 3 months after surgery. The owner reported no postoperative complications (i.e., thrombosis), and the patient was brought for a check-up 4 months after the operation in good health. CONCLUSIONS: For surgical MMVD cases complicated with impaired sinus function, the chances of spontaneous sinus rhythm are low, requiring pacemaker implantation. LAA closure may be considered to protect against decreased atrial function after mitral valvuloplasty and prevent intra-atrial thrombus formation.


Subject(s)
Atrial Appendage/surgery , Atrial Fibrillation/veterinary , Dog Diseases/surgery , Mitral Valve Prolapse/veterinary , Pacemaker, Artificial/veterinary , Postoperative Complications/veterinary , Animals , Atrial Fibrillation/therapy , Cardiopulmonary Bypass/veterinary , Dog Diseases/diagnostic imaging , Dog Diseases/therapy , Dogs , Echocardiography/veterinary , Heart Arrest/prevention & control , Heart Arrest/veterinary , Male , Mitral Valve/surgery , Mitral Valve Prolapse/surgery , Postoperative Complications/surgery , Thrombosis/etiology , Thrombosis/veterinary
15.
J Vet Emerg Crit Care (San Antonio) ; 32(4): 491-499, 2022 Jul.
Article in English | MEDLINE | ID: mdl-35318792

ABSTRACT

OBJECTIVE: To describe circumstances and outcomes following cardiopulmonary arrest (CPA) in hospitalized birds. DESIGN: Retrospective case study. SETTING: Academic medical center. METHODS: The hospital medical records system was searched for avian cases that underwent CPR. Medical records were reviewed; data retrieved included association of CPA with anesthesia or handling, use of external compressions and intubation, drug administration, rates of return of spontaneous circulation (ROSC), and outcome. Cases with incomplete medical records were excluded. RESULTS: Forty-one cases of avian CPR were identified. Anesthesia-related arrest was reported in 26 of 41 cases. The remainder of CPA events occurred during an examination (6/41) or were observed during hospitalization for treatment of disease or injury (11/41). Compressions were performed in 14 birds and manual ventilation performed in 21 of 41 cases via intubation (19/21), tight-fitting face mask (1/21), or air sac cannulation (1/21). Vascular access was achieved in 24 of 41 cases. Emergency drug administration was documented in 22 of 41 cases and included epinephrine (20/22), atropine (19/22), glycopyrrolate (3/22), doxapram (2/22), dextrose (3/22), mannitol (1/22), and furosemide (1/22). Fluid therapy was administered in 24 of 41 cases. There were 3 documented cases of ROSC (7%), all in patients under general anesthesia, and 1 (2%) CPA survivor. CONCLUSIONS: There was no standardized approach to avian CPR in this study, and ROSC was rare. When ROSC was achieved, birds were under general anesthesia with direct monitoring by a clinician, were ventilated, and were administered anesthetic reversals and anticholinergic or catecholamine emergency medications. These poor outcomes suggest that further research and an updated standardized approach to avian CPR, with special consideration of the physiological differences from mammals, are needed.


Subject(s)
Cardiopulmonary Resuscitation , Heart Arrest , Animals , Birds , Cardiopulmonary Resuscitation/veterinary , Heart Arrest/therapy , Heart Arrest/veterinary , Hospitalization , Mammals , Retrospective Studies
16.
Equine Vet J ; 54(5): 927-933, 2022 Sep.
Article in English | MEDLINE | ID: mdl-34738246

ABSTRACT

A 10-year-old 466 kg mustang gelding presented to an equine referral hospital for surgical repair of nasal, frontal and lacrimal bone fractures from an unknown trauma. Surgical repair was performed under general anaesthesia, including a right-sided maxillary regional anaesthetic block with mepivacaine hydrochloride. Progressive hyperkalaemia was documented perianaesthetically (T-3 mins; 134 mins after induction; potassium 6.4 mmol/L (ref 3.5-5.1 mmol/L). Perianaesthetic bradycardia was attributed to alpha -2 agonist infusion administration, and other characteristic ECG changes (flattened P waves, narrow T waves of increased amplitude, prolonged QRS complex) were not documented. Asystole occurred 137 min after induction of anaesthesia; however, a review of the available literature suggests the degree of hyperkalaemia documented was unlikely to be the primary cause of asystole but may have been a contributing factor. It is hypothesised that a trigeminocardiac reflex was the primary contributory factor to asystole in the described case, and may represent a maxillomandibulocardiac reflex that has not been previously described in the horse.


Subject(s)
Heart Arrest , Horse Diseases , Hyperkalemia , Animals , Arrhythmias, Cardiac/veterinary , Blood Pressure , Heart Arrest/chemically induced , Heart Arrest/veterinary , Horse Diseases/chemically induced , Horses , Hyperkalemia/complications , Hyperkalemia/veterinary , Male , Reflex
17.
J Vet Emerg Crit Care (San Antonio) ; 32(1): 129-134, 2022 Jan.
Article in English | MEDLINE | ID: mdl-34499802

ABSTRACT

OBJECTIVE: To describe a case of successful return of spontaneous circulation in an anesthetized dog that developed spontaneous ventricular fibrillation during CPR that was refractory to multiple defibrillation attempts by utilizing pharmacological antiarrhythmic therapy. CASE SUMMARY: Cardiopulmonary arrest occurred during surgical preparation in a 1-year-old German Shepherd Dog under general anesthesia for fluoroscopic implantation of an Amplatz canine duct occluder for treatment of a patent ductus arteriosus. Pulseless electrical activity was initially diagnosed, and resuscitative efforts were immediately initiated, including basic cardiac life support, discontinuation of anesthesia with administration of reversal agents, and low-dose epinephrine administration (0.01 mg/kg, IV). After 10 minutes of CPR, the patient developed ventricular fibrillation and single-dose monophasic defibrillation attempts of escalating energy were performed. Despite these efforts, return of spontaneous circulation was unable to be achieved. However, administration of magnesium sulfate (20 mg/kg, IV) along with an additional single monophasic defibrillation attempt was successful in achieving return of spontaneous circulation. NEW OR UNIQUE INFORMATION PROVIDED: Under current advanced cardiac life support guidelines, the best resuscitation strategy for refractory ventricular fibrillation, in which the arrhythmia persists despite multiple defibrillation attempts, remains unclear. This is especially true for veterinary patients, where refractory ventricular fibrillation is an uncommon cardiac arrest rhythm. Although guidelines for the use of antiarrhythmic therapy during cardiac arrest are well established in human medicine, evidence-based guidelines to support best practices in companion animals do not exist due to sparse data gathered through experimental studies. Only a few case reports describe successful return of spontaneous circulation following prolonged ventricular fibrillation in clinical veterinary patients. Although the use of magnesium sulfate as an antiarrhythmic agent during refractory ventricular fibrillation has been previously reported in people, this is the first case to our knowledge of refractory ventricular fibrillation in a dog that responded to magnesium sulfate.


Subject(s)
Cardiopulmonary Resuscitation , Dog Diseases , Heart Arrest , Animals , Cardiopulmonary Resuscitation/veterinary , Dog Diseases/drug therapy , Dogs , Electric Countershock/veterinary , Epinephrine , Heart Arrest/therapy , Heart Arrest/veterinary , Humans , Ventricular Fibrillation/therapy , Ventricular Fibrillation/veterinary
19.
Sci Rep ; 11(1): 16138, 2021 08 09.
Article in English | MEDLINE | ID: mdl-34373497

ABSTRACT

To compare the effect on the recovery of spontaneous circulation (ROSC) of early endotracheal intubation (ETI) versus bag-mask ventilation (BMV), and expiratory real-time tidal volume (VTe) feedback (TVF) ventilation versus without feedback or standard ventilation (SV) in a pediatric animal model of asphyxial cardiac arrest. Piglets were randomized into five groups: 1: ETI and TVF ventilation (10 ml/kg); 2: ETI and TVF (7 ml/kg); 3: ETI and SV; 4: BMV and TVF (10 ml/kg) and 5: BMV and SV. Thirty breaths-per-minute guided by metronome were given. ROSC, pCO2, pO2, EtCO2 and VTe were compared among groups. Seventy-nine piglets (11.3 ± 1.2 kg) were included. Twenty-six (32.9%) achieved ROSC. Survival was non-significantly higher in ETI (40.4%) than BMV groups (21.9%), p = 0.08. No differences in ROSC were found between TVF and SV groups (30.0% versus 34.7%, p = 0.67). ETI groups presented lower pCO2, and higher pO2, EtCO2 and VTe than BMV groups (p < 0.05). VTe was lower in TVF than in SV groups and in BMV than in ETI groups (p < 0.05). Groups 1 and 3 showed higher pO2 and lower pCO2 over time, although with hyperventilation values (pCO2 < 35 mmHg). ETI groups had non significantly higher survival rate than BMV groups. Compared to BMV groups, ETI groups achieved better oxygenation and ventilation parameters. VTe was lower in both TVF and BMV groups. Hyperventilation was observed in intubated animals with SV and with 10 ml/kg VTF.


Subject(s)
Airway Management , Asphyxia , Cardiopulmonary Resuscitation , Heart Arrest , Animals , Airway Management/methods , Airway Management/veterinary , Asphyxia/physiopathology , Asphyxia/therapy , Asphyxia/veterinary , Cardiopulmonary Resuscitation/methods , Cardiopulmonary Resuscitation/veterinary , Disease Models, Animal , Heart Arrest/physiopathology , Heart Arrest/therapy , Heart Arrest/veterinary , Hemodynamics , Intubation, Intratracheal/veterinary , Linear Models , Respiration , Swine , Swine, Miniature , Tidal Volume
20.
J Vet Emerg Crit Care (San Antonio) ; 31(6): 718-726, 2021 Nov.
Article in English | MEDLINE | ID: mdl-34432941

ABSTRACT

OBJECTIVE: To describe the use of a postarrest debriefing tool (DBT) within a university teaching hospital and to evaluate user perceptions of the tool. DESIGN: Observational study over a 1-year period and associated hospital clinical personnel survey. SETTING: University teaching hospital. INTERVENTIONS: Qualitative data surrounding the use and utility of the DBT were analyzed, as well as survey results. MEASUREMENTS AND MAIN RESULTS: Forty-four arrests occurred during the study period. Debriefing was performed after 26 of 44 (59%) cardiopulmonary resuscitation (CPR) events, of which 22 of 26 (85%) were recorded using the DBT and four without the DBT. Return of spontaneous circulation did not significantly affect the use of the DBT (p = 0.753). Most events in which debriefing was not performed occurred outside of business hours (13/18; 72%). The most frequent positive debriefing comments related to cooperation/coordination within the team (22/167; 13%). The most frequent negative debriefing comments concerned equipment issues (36/167; 22%). Of the action points generated, 57% (34/60) were directed at equipment use/availability. Teams reported that emergency drugs were appropriately administered in 21 of 22 (95%) cases. In contrast, closed loop communication was reportedly only used during 6 of 22 (27%) events. The hospital survey response rate was 56 of 338 (17%) clinical staff, of whom 37 of 56 (66%) agreed or strongly agreed that debriefing had improved team performance during CPR. Overall, 33 of 56 (60%) staff felt that the DBT had improved the debriefing process at the hospital. However, 3 of 56 (5%) staff members felt that they were unable to state their opinions in a blame-free environment during debriefing. CONCLUSIONS: Implementation of a DBT enabled formal identification of strengths and training needs of resuscitation teams, and its implementation was viewed positively by the majority of hospital staff. However, further refinement of the tool and prospective studies evaluating its efficacy in improving outcome are warranted.


Subject(s)
Cardiopulmonary Resuscitation , Heart Arrest , Animals , Cardiopulmonary Resuscitation/veterinary , Heart Arrest/therapy , Heart Arrest/veterinary , Hospitals, University , Prospective Studies
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