ABSTRACT
We report the case of a severe haemophilia A patient with an anti-factor VIII antibody who presented with a thigh haematoma and 1 year later with an elbow haemarthrosis infected by Salmonella enteritidis. These two infections were treated by antibiotics. The probable origin of these infections seems to be an anal fistula. The occurrence of a septic arthritis due to Salmonella is rare, and to our knowledge has never been reported in HIV-negative haemophilic patients. The differential diagnosis of haemarthrosis and septic arthritis in a haemophilic patient is also discussed.
Subject(s)
HIV Seronegativity , Hemarthrosis/immunology , Hemophilia A/immunology , Salmonella Infections/immunology , Salmonella enteritidis/isolation & purification , Adult , Chronic Disease , Diagnosis, Differential , Female , Hemarthrosis/microbiology , Hemophilia A/microbiology , HumansABSTRACT
A 20-year-old male athlete had Lyme arthritis and an associated atraumatic spontaneous hemarthrosis of the knee. Lyme arthritis is a common and well-documented manifestation of Lyme disease, but an association with an atraumatic hemarthrosis to date has not been reported. Clinical diagnosis was confirmed by serologic testing. Treatment consisted of ceftriaxone, 1-g intravenous for 14 days.
Subject(s)
Arthritis, Infectious/microbiology , Hemarthrosis/microbiology , Lyme Disease/complications , Adult , Ceftriaxone/therapeutic use , Hemarthrosis/diagnosis , Humans , Lyme Disease/diagnosis , Lyme Disease/drug therapy , Magnetic Resonance Imaging , MaleABSTRACT
In rabbit knees 600 Staphylococcus aureus organisms produced progressive infection in 50 per cent of the knees injected, whereas 5.3 times 10-7 Micrococcus species caused only transient colonization of the joints. Methicillin, cephacetrile, and clindamycin administered before injection of the staphylococci gave protection. Stainless-steel particles in the knee did not increase susceptibility to infection from injected micrococci but did make established micrococcal infections more persistent. Knees containing steel debris failed to become infected during prolonged staphylococcal bacteremia. Injected autologous blood, either fresh or three days old, did not increase susceptibility to infection. Large doses of steroids, given systemically or intraarticularly, decreased resistance to micrococcal infection and increased the destruction caused by infection due to this organism.
