ABSTRACT
An adult, intact female Australian shepherd presented for frank vaginal bleeding of unknown duration. The only coagulation profile abnormality upon presentation was mild prolongation of the partial thromboplastin time (PTT). The uterus was removed at surgery and contained a large amount of coagulated blood. Clotting profiles were markedly abnormal 48 hours postoperatively. Serum analysis was positive for brodifacoum, an anticoagulant rodenticide. Preoperative coagulation was most likely normalized by vitamin K1 therapy administered prior to presentation. The only manifestation of anticoagulant rodenticide was hematometra. Rodenticide intoxication should be considered in the differential diagnosis list of hematometra or metrorrhagia.
Subject(s)
4-Hydroxycoumarins/poisoning , Dog Diseases/chemically induced , Hematometra/veterinary , Rodenticides/poisoning , Uterine Hemorrhage/veterinary , Animals , Blood Coagulation Tests/veterinary , Diagnosis, Differential , Dog Diseases/surgery , Dogs , Female , Hematometra/chemically induced , Hematometra/surgery , Hemostatics/therapeutic use , Ultrasonography , Uterine Hemorrhage/chemically induced , Uterine Hemorrhage/surgery , Uterus/diagnostic imaging , Uterus/surgery , Vitamin K/therapeutic useABSTRACT
A postmenopausal woman, receiving cyclic hormonal therapy, presented to our clinic with acute pelvic pain, absence of withdrawal bleeding and clinical signs of vagal stimulation (nausea and vomiting). Vaginal exploration and ultrasonographic imaging accounted for haematocervix, which was confirmed by surgical blood evacuation.
Subject(s)
Estrogen Replacement Therapy/adverse effects , Hematometra/chemically induced , Female , Hematometra/diagnostic imaging , Humans , Middle Aged , UltrasonographyABSTRACT
Hematometra developed in a patient receiving sequential estrogen-progestogen hormone replacement therapy following radiation for cervical carcinoma. Diagnosis, treatment and therapeutic recommendations are discussed.
