ABSTRACT
In a 9-year period (1980-1988), 46 delivered hemoglobinopathy patients were studied. There was a high incidence of complications during pregnancy. The perinatal and maternal mortalities were 13.4% and 9.2% respectively. The complications could be minimized by adequate supervision in pregnancy, labor and puerperium.
Subject(s)
Anemia, Sickle Cell/epidemiology , Hemoglobin C Disease/epidemiology , Pregnancy Complications, Hematologic/epidemiology , Anemia, Sickle Cell/mortality , Anemia, Sickle Cell/therapy , Birth Weight , Delivery, Obstetric/methods , Female , Hemoglobin C Disease/mortality , Hemoglobin C Disease/therapy , Hospitals, University , Humans , Incidence , Infant Mortality , Infant, Newborn , Maternal Mortality , Nigeria/epidemiology , Obstetrics/standards , Parity , Pregnancy , Pregnancy Complications, Hematologic/mortality , Pregnancy Complications, Hematologic/therapy , Pregnancy Outcome , Retrospective StudiesABSTRACT
The pattern of infection was compared in 139 children with sickle cell-hemoglobin C (SC) disease and in 250 control children with a normal hemoglobin (AA) genotype ascertained at birth and followed prospectively for periods of zero to six years. Both infection incidence rates and survival curve analysis indicated highly significant increases in serious infection among children with SC disease. Respiratory infection and gastroenteritis were the most common infections, but only respiratory infections were significantly more frequent in SC disease. Pneumococcal bacteremia was confined to the SC group. No hematologic differences were apparent between SC patients with and without a history of serious infection, but infection was significantly more common in patients manifesting early splenomegaly.
Subject(s)
Bacterial Infections/epidemiology , Hemoglobin C Disease/complications , Pneumococcal Infections/epidemiology , Bacterial Infections/complications , Bacterial Infections/mortality , Child , Child, Preschool , Hemoglobin C Disease/mortality , Humans , Infant , Infant, Newborn , Jamaica , Pneumococcal Infections/complicationsABSTRACT
In Jamaican children with homozygous sickle cell (SS) disease diagnosed at birth two-year survival was 87%, compared with 95% in children with sickle cell-haemoglobin C (CS) disease, and 99% in normal controls. Death among those with SS disease occurred most often between the ages of 6 and 12 months. Principal causes were acute splenic sequestration and pneumococcal infection. Neonatal diagnosis of haemoglobinopathies must be followed by close observation if mortality is to be reduced by early diagnosis and treatment of these complications.
Subject(s)
Anemia, Sickle Cell/mortality , Hemoglobin C Disease/mortality , Age Factors , Anemia, Sickle Cell/diagnosis , Child, Preschool , Follow-Up Studies , Humans , Infant , Infant, Newborn , Infant, Newborn, Diseases/diagnosis , Jamaica , Pneumococcal Infections/mortalityABSTRACT
In Jamaican children with homozygous sickle cell (SS) disease diagnosed at birth two-year survival was 87 percent, compared with 95 percent in children with sickle cell-haemoglobin C (SC) disease, and 99 percent in normal controls. Death among those with SS disease occurred most often between the ages of 6 and 12 months. Principal causes were acute splenic sequestration and pneumococcal infection. Neonatal diagnosis of haemoglobinopathies must be followed by close observation if mortality is to be reduced by early diagnosis and treatment of these complications. (AU)
