ABSTRACT
Efficacy of drug therapy of Omsk hemorrhagic fever (OHF) was tested experimentally using cell culture and laboratory animals infected with the OHF virus strain Ondatra. Screening tests showed that high concentrations of Virazol or interferon inducers Larifan and Rifastin caused moderately pronounced suppression of virus reproduction in cell culture. Realdiron was found to be a high-efficacy preparation causing complete inhibition of virus reproduction in cell. Larifan demonstrated the highest antiviral efficacy against OHF virus in experiments with laboratory animals. This drug prevented the death of 65% infected mice and significantly decreased infection process severity in rabbits.
Subject(s)
Antiviral Agents/therapeutic use , Encephalitis Viruses, Tick-Borne , Hemorrhagic Fever, Omsk/drug therapy , Interferon Inducers/therapeutic use , Interferon Type I/therapeutic use , Ribavirin/therapeutic use , Animals , Cell Culture Techniques , Disease Models, Animal , Disease Progression , Hemorrhagic Fever, Omsk/pathology , Mice , Organic Chemicals , Rabbits , Recombinant Proteins , Virus Replication/drug effectsABSTRACT
The author sums up the data on the history of discovery and research of Omsk hemorrhagic fever (OHF), comparative characteristics of its natural foci, and clinical features of epizootic and epidemic processes at the end of the 1940s and at present. Presents the modern concept of OHF virus ecology and discusses differences of its biological properties in the strains isolated from different sources. Based on analysis of many-year findings and major publications, the author offers a long-term epizootological and epidemic prognosis for OHF in endemic territories.
Subject(s)
Hemorrhagic Fever, Omsk/epidemiology , Animals , Arachnid Vectors , Disease Reservoirs , Hemorrhagic Fever, Omsk/pathology , Hemorrhagic Fever, Omsk/transmission , Humans , Russia/epidemiologyABSTRACT
Morphological characterization of OHF virus was studied by means of thin section electron microscopy in the brains of mice infected with Omsk hemorrhagic fever virus. The crystals, microvesicles, vacuoles and as beehive structures were observed in the virus-infected cells. The possible relationship between the characteristic structures and virus morphogenesis is discussed. It is indicated that these characteristic structures may be important to morphological characterization of OHF virus.
