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J Org Chem ; 74(15): 5584-9, 2009 Aug 07.
Article in English | MEDLINE | ID: mdl-19572595

ABSTRACT

The total synthesis of pteridic acids A and B is reported. The convergent asymmetric synthesis involved the use of a diastereoselective ethyl ketone aldol reaction followed by an efficient spiroketalization and provided pteridic acids A and B in 2.9% and 2.8% overall yield, respectively.


Subject(s)
Heptanoic Acids/chemical synthesis , Spiro Compounds/chemical synthesis , Heptanoic Acids/chemistry , Molecular Conformation , Spiro Compounds/chemistry , Stereoisomerism
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