ABSTRACT
The experiments on 130 rat males have shown that the exposure of the animals' liver to centimeter microwaves enhances catalytic activity of P-450p cytochrome, an enzyme of drug microsomal metabolism. However, changes in pharmacokinetic parameters of elimination from the blood of the drugs based on microsomal substrates of hepatic enzymatic system are more dependent on the microwaves' impact on physiological factors modifying drug pharmacokinetics. This implies the necessity of pharmacokinetic investigations in each individual case of combining drugs with microwaves.
Subject(s)
Antipyrine/radiation effects , Hexobarbital/radiation effects , Microsomes, Liver/radiation effects , Microwaves , Animals , Antipyrine/pharmacokinetics , Biological Transport/radiation effects , Catalysis/radiation effects , Cytochrome P-450 Enzyme System/metabolism , Cytochrome P-450 Enzyme System/radiation effects , Hexobarbital/pharmacokinetics , Male , Microsomes, Liver/enzymology , Rats , Rats, Wistar , Serum Albumin/metabolism , Serum Albumin/radiation effects , Time FactorsSubject(s)
Aminopyrine/radiation effects , Hexobarbital/radiation effects , Microwaves , Phenylbutazone/radiation effects , Aminopyrine/blood , Animals , Biotransformation/radiation effects , Hexobarbital/blood , Liver/metabolism , Liver/radiation effects , Male , Phenylbutazone/blood , Rats , Rats, Inbred StrainsABSTRACT
It is established that the hexobarbital oxidase activity of 12,000 g rat liver supernatant does not change when examined at the 2nd h after whole body irradiation (700 R) but increases at longer postexposure periods (72 hours). Intraperitoneal injection of phenobarbital in daily doses of 80 mg/kg body wt for three days increases the hexobarbital oxidase activity of non-irradiated rats, the effect being much stronger in phenobarbital-treated rats at the 2nd h of postirradiation. The possible mechanisms of these effects are discussed, as well as their correlation with the increased lipid peroxidation and their significance for the radiation effect on the drug action.