ABSTRACT
This is a case report of a 33 year old woman with a history of psychosis, who presented to the women's mental health clinic for consultation at the 12(th) week of gestation, having already received olanzapine throughout the first trimester. She was followed from that point on at our clinic and remained on small doses of olanzapine for the rest of her pregnancy, which was uncomplicated. She gave birth to a healthy female, which at the age of three months was diagnosed with developmental dysplasia of the hip and subsequently received appropriate treatment with favorable outcome. The possibility of the association of this congenital dysplasia with the use of olanzapine during pregnancy is further discussed in this paper.
Subject(s)
Antipsychotic Agents/adverse effects , Hip Dislocation, Congenital/chemically induced , Pregnancy Complications/drug therapy , Prenatal Exposure Delayed Effects , Psychotic Disorders/drug therapy , Adult , Antipsychotic Agents/administration & dosage , Benzodiazepines/administration & dosage , Benzodiazepines/adverse effects , Female , Hip Dislocation, Congenital/therapy , Humans , Infant, Newborn , Olanzapine , Pregnancy , Prenatal Care/methods , Treatment OutcomeSubject(s)
Abnormalities, Drug-Induced , Anticonvulsants/adverse effects , Hip Dislocation, Congenital/chemically induced , Phenytoin/adverse effects , Acetabulum/surgery , Adult , Epilepsy/drug therapy , Female , Hip Dislocation, Congenital/diagnostic imaging , Hip Dislocation, Congenital/surgery , Humans , Male , Osteotomy , Pregnancy , Pregnancy Complications/drug therapy , Radiography , SyndromeABSTRACT
Possible teratogenic effects of exogenous progestational agents given during early pregnancy were investigated by a controlled historic prospective study of 2754 infants born to mothers who had bled during the first trimester of pregnancy. The study group consisted of 1608 newborns whose mothers had been treated with progestogens (mostly medroxyprogesterone acetate) beginning in the first trimester. The control group comprised 1146 infants of untreated mothers. All newborns were subjected to thorough examination during the first days of life, with special attention to detection of various malformations classified according to the different anatomic systems. No significant difference was found between the treated and the control groups with respect to malformations in any of the systems examined. The overall rate of malformations was 120 per 1000 in the study group and 123.9 per 1000 in the control group. Major malformations occurred at rates of 63.4 and 71.5 per 1000, respectively. The study thus fails to demonstrate an increase in teratogenicity after administration of gestagens during the first trimester of pregnancy.
Subject(s)
Abnormalities, Drug-Induced/epidemiology , Medroxyprogesterone/analogs & derivatives , Abortion, Habitual/drug therapy , Adult , Anencephaly/chemically induced , Female , Heart Defects, Congenital/chemically induced , Hip Dislocation, Congenital/chemically induced , Humans , Hydrocephalus/chemically induced , Infant, Newborn , Medroxyprogesterone/adverse effects , Medroxyprogesterone Acetate , Pregnancy , Pregnancy Trimester, First , Spina Bifida Occulta/chemically inducedSubject(s)
Dog Diseases/etiology , Hip Dislocation, Congenital/veterinary , Vitamin B Complex/adverse effects , Animals , Dog Diseases/chemically induced , Dogs , Hip Dislocation, Congenital/chemically induced , Hip Dislocation, Congenital/etiology , Hip Dysplasia, Canine/chemically induced , Hip Dysplasia, Canine/etiologyABSTRACT
Two siblings have various congenital malformations due to the teratogenic effect of anticonvulsant drugs. Their mother has a 14-year history of continuous anticonvulsant medication. The malformations noted in the older girl are less and in the 8 years younger sister more extensively developed as well as in the fetal hydantoin syndrome. The causes of different severity of the fetal hydantoin syndrome in two sisters are discussed.
Subject(s)
Abnormalities, Drug-Induced , Hydantoins/adverse effects , Abnormalities, Drug-Induced/prevention & control , Abnormalities, Multiple/chemically induced , Adolescent , Child , Epilepsy/drug therapy , Female , Fingers/abnormalities , Foot Deformities, Congenital , Hip Dislocation, Congenital/chemically induced , Humans , Hydantoins/therapeutic use , Hypertelorism/chemically induced , Pregnancy , Pregnancy Complications/drug therapy , Prenatal Care , SyndromeSubject(s)
Hip Dislocation, Congenital/etiology , Relaxin/physiology , Age Factors , Animals , Child , Child, Preschool , Female , Guinea Pigs , Hip Dislocation, Congenital/chemically induced , Humans , In Vitro Techniques , Infant , Infant, Newborn , Male , Maternal-Fetal Exchange , Pregnancy , Relaxin/adverse effectsABSTRACT
LSD treated males were mated with untreated females and their progeny examined by S-R. The incidence of morphological anomalies in the offsprings of control animals appears to be important but is doubled in the progeny of LSD treated males. Our observations are limited to the limbs, the vertebrae, the ribs and the pelvic girdle.
Subject(s)
Abnormalities, Drug-Induced/diagnostic imaging , Lysergic Acid Diethylamide/toxicity , Animals , Extremities/diagnostic imaging , Growth Disorders/chemically induced , Hip Dislocation, Congenital/chemically induced , Osteogenesis/drug effects , Radiography , Skeleton/diagnostic imaging , Spine/diagnostic imaging , TriturusABSTRACT
A child aged 24 months had multiple congenital abnormalities and delayed development. The 28-year-old mother had been treated since childhood with anticonvulsants. Her previous pregnancies had resulted in three early spontaneous abortions and one child with severe bilateral cleft lip and palate. This case report further suggests a relationship between maternal diphenylhydantoin use and fetal anomalies.
