ABSTRACT
We report the case of a 73-year-old American traveler who presented with 3 weeks of fatigue, fevers, chills, and pancytopenia. Clinical and laboratory findings were consistent with hemophagocytic lymphohystiocytosis (HLH) and bone marrow biopsy revealed amastigotes consistent with visceral leishmaniasis. The range of endemic visceral leishmaniasis transmission now extends into northern Spain and travelers to this region should use personal protective measures against sand fly exposure.
Subject(s)
Histiocytosis, Non-Langerhans-Cell/parasitology , Insect Bites and Stings/parasitology , Leishmania donovani/isolation & purification , Leishmaniasis, Visceral/parasitology , Travel , Aged , Bone Marrow/parasitology , Bone Marrow/pathology , Histiocytosis, Non-Langerhans-Cell/drug therapy , Humans , Leishmaniasis, Visceral/drug therapy , Leishmaniasis, Visceral/pathology , Male , Spain , Treatment Outcome , United StatesABSTRACT
Hemophagocytosis, either primary (familial) or secondary (reactive), is a life threatening condition in childhood. Etiology should be vigorously searched to avoid a diagnosis of primary hemophagocytosis and treatment with cytotoxic drugs. A child with visceral leishmaniasis causing hemophagocytosis is presented.
Subject(s)
Histiocytosis, Non-Langerhans-Cell/complications , Leishmaniasis, Visceral/complications , Female , Histiocytosis, Non-Langerhans-Cell/parasitology , Humans , InfantABSTRACT
Since the first description of infection-associated hemophagocytosis (IAHS), the list of precipitating infectious agents causing hemophagocytic syndrome has grown. A lymphohistiocytic proliferation with hemophagocytosis may develop as a result of macrophage activation, viral or bacterial infection, parasitic infestations, or malignancy. The authors report on a 3-year-old boy with Langerhans cell histiocytosis (LCH), who developed IAHS during malaria infection. Hemophagocytic syndromes may complicate the course of LCH and cause diagnostics problems. Malaria is one of many infections that can precipitate secondary hemophagocytic lymphohistiocytosis.
Subject(s)
Histiocytosis, Langerhans-Cell/complications , Histiocytosis, Non-Langerhans-Cell/diagnosis , Histiocytosis, Non-Langerhans-Cell/etiology , Malaria/complications , Blood Cells/parasitology , Child, Preschool , Headache/etiology , Histiocytosis, Langerhans-Cell/parasitology , Histiocytosis, Non-Langerhans-Cell/parasitology , Histiocytosis, Non-Langerhans-Cell/therapy , Humans , MaleABSTRACT
We describe a 23-year-old retired military officer who was immunocompetent but diagnosed with hemophagocytic syndrome (HPS) by Plasmodium vivax infection. Initially, the patient was suspected to have toxic hepatitis related to heavy drinking. But abnormal hematologic findings required a further bone marrow examination and the diagnosis of HPS was made. Antimalarial chemotherapy then brought complete remission. Plasmodium falciparum, a species causing more severe malarial infection, was listed as one of the major causes of HPS. However, P. vivax was not mentioned, and only one case was reported in the literature. In this study, we suggest that P. vivax malaria should be included in the differential diagnosis of HPS, even in an immunocompetent person.
Subject(s)
Histiocytosis, Non-Langerhans-Cell/immunology , Histiocytosis, Non-Langerhans-Cell/parasitology , Immunocompetence , Malaria, Vivax/complications , Military Personnel , Adult , Antimalarials/therapeutic use , Bone Marrow/pathology , Histiocytosis, Non-Langerhans-Cell/drug therapy , Histiocytosis, Non-Langerhans-Cell/pathology , Humans , MaleABSTRACT
Pancytopenia in an acutely ill child is commonly a result of bone marrow suppression. Rarely pancytopenia is a manifestation of inappropriate macrophage activation associated with hemophagocytosis. Viral infections account for most cases of secondary hemophagocytosis. We report a case of malaria-associated hemophagocytosis in a child from an endemic area. Systemic parasitic infections should be included in the differential diagnosis of pancytopenia and infection-associated hemophagocytosis. In this rare subgroup of hemophagocytosis, malaria caused by Plasmodium falciparum is the most common parasitic infection
Subject(s)
Histiocytosis, Non-Langerhans-Cell/complications , Histiocytosis, Non-Langerhans-Cell/parasitology , Malaria/complications , Pancytopenia/complications , Animals , Antimalarials/therapeutic use , Child , Diagnosis, Differential , Female , Histiocytosis, Non-Langerhans-Cell/drug therapy , Humans , Malaria/drug therapy , Malaria/parasitology , Mefloquine/therapeutic use , Plasmodium falciparum/isolation & purification , Plasmodium vivax/isolation & purification , Primaquine/therapeutic useABSTRACT
The authors report a case of hemophagocytic syndrome (HPS) associated with acute visceral leishmaniasis (VL). A 4-year-old boy was admitted with high fever, hepatosplenomegaly, and pancytopenia. Elevated serum ferritin and triglyceride, low fibrinogen levels, and bone-marrow (BM) histiocytic hyperplasia with prominent hemophagocytosis were consistent with a HPS. An initial diagnosis of kala-azar was refuted because of negativity of BM aspiration and serology for this parasite, and the diagnosis HPS was made. Three months after first admission, reevaluation of the BM aspiration revealed many amastigotes of Leishmania parasites. The serology of VL became positive, finally establishing the diagnosis of VL. Although specific therapy for VL was instituted, the patient died 4 weeks after the diagnosis.
Subject(s)
Histiocytosis, Non-Langerhans-Cell/parasitology , Leishmaniasis, Visceral/complications , Bone Marrow/parasitology , Child, Preschool , Critical Illness , Fatal Outcome , Gastrointestinal Hemorrhage/etiology , Humans , Leishmaniasis, Visceral/diagnosis , Leishmaniasis, Visceral/drug therapy , Male , Opportunistic Infections/etiologySubject(s)
Histiocytosis, Non-Langerhans-Cell/parasitology , Malaria, Falciparum/complications , Aged , Animals , Ferritins/deficiency , Histiocytosis, Non-Langerhans-Cell/complications , Histiocytosis, Non-Langerhans-Cell/diagnosis , Humans , Hypertriglyceridemia/etiology , L-Lactate Dehydrogenase/blood , Male , Pancytopenia/etiologyABSTRACT
A 41-year-old woman was admitted with fever, splenomegaly and pancytopenia. High serum ferritin, hypertriglyceridaemia and bone marrow haemophagocytosis were consistent with a haemophagocytic syndrome. Trophozoites and gametocytes of Plasmodium vivax were identified on blood smear. Rapid recovery was observed after treatment with oral chloroquine.