Subject(s)
Homosexuality/therapy , Psychotherapy, Group , Ambulatory Care , Antidepressive Agents/therapeutic use , Goals , Homosexuality/drug therapy , Hospitalization , Hostility , Humans , Interpersonal Relations , Psychodrama , Psychotherapy, Multiple , Rejection, Psychology , Sex Factors , Sex Offenses , Sexual Behavior , Social Adjustment , Tranquilizing Agents/therapeutic useABSTRACT
Evidence for the role of androgens in the male aggressive and sexual behavior is reviewed. Medroxyprogesterone acetate (MPA; Provera, Upjohn) has a marked antiandrogen property; it is effective in lowering the testosterone level and controlling certain otherwise intractable sex deviations. The finding in 6 patients treated for sex deviation are summarized. The effects of MPA in the treatment of 11 temporal lobe epileptics and 5 other patients with severe angry-aggressive behavior disorder are reported. Most temporal lobe epileptics responded well to MPA. Weight gain and earlier sleep were consistent side effects. The values of plasma testosterone, serum luteinizing hormone, and urinary 17-ketosteroids were decreased by the treatment. Four patients were XYY individuals with lack of control over their sexual-aggressive or angry-aggressive impulses.
Subject(s)
Aggression/drug effects , Medroxyprogesterone/therapeutic use , Mental Disorders/drug therapy , 17-Hydroxycorticosteroids/urine , Acne Vulgaris/complications , Acne Vulgaris/drug therapy , Adolescent , Adult , Electroencephalography , Epilepsy, Absence/complications , Epilepsy, Absence/drug therapy , Epilepsy, Post-Traumatic/complications , Epilepsy, Post-Traumatic/drug therapy , Epilepsy, Temporal Lobe/drug therapy , Homosexuality/drug therapy , Humans , Luteinizing Hormone/blood , Male , Medroxyprogesterone/administration & dosage , Medroxyprogesterone/adverse effects , Paraphilic Disorders/drug therapy , Paraphilic Disorders/etiology , Paraphilic Disorders/metabolism , Rehabilitation, Vocational , Sex Chromosome Aberrations , Social Behavior Disorders/complications , Social Behavior Disorders/metabolism , Social Behavior Disorders/rehabilitation , Transvestism/drug therapyABSTRACT
Interference of pregnancy steroid hormones with FPN test for estimation of some phenothiazine derivatives in urine has been investigated. The FPN test was positive in 97.9% of urine samples obtained from pregnant women. It is supposed that metabolites of estrogens and progestagens present in higher amounts in urine samples of these women are responsible for this positivity.
