Bio-active cements-Mineral Trioxide Aggregate based calcium silicate materials: a narrative review.

Recent advances in the field of endodontics have greatly improved the outcome and success rate of dental materials. For last three decades, there has been great interest in the development of bioactive dental material with the ability to interact and induce surrounding dental tissues to promote regeneration of pulpal and periradicular tissues. As these bioactive materials are mainly based on calcium silicates, they are also referred to as Calcium Silicate materials. The first material introduced was Mineral Tri-oxide Aggregate, which, due to its favourable biological properties, gained importance initially. However, later, due to its drawbacks, liked is colouration, long setting time and difficult manipulation, several modifications were done and newer bioactive materials, such as Biodentine, BioAggregate, Endosequence, Calcium-Enriched Mixture etc., were developed. The main applications of these materials are for pulp capping (direc t/indirec t), pulpotomy, perforation repair, resorption defects, apexogenesis and as retrograde filling materials, apexification and endodontic sealers. This review discusses the various types of bioactive materials, their composition, setting mechanism, and literature evidence for current applications.

Nature's design solutions in dental enamel: Uniting high strength and extreme damage resistance.

The most important demand of today's high-performance materials is to unite high strength with extreme fracture toughness. The combination of withstanding large forces (strength) and resistance to fracture (toughness), especially preventing catastrophic material failure by cracking, is of utmost importance when it comes to structural applications of these materials. However, these two properties are commonly found to be mutually exclusive: strong materials are brittle and tough materials are soft. In dental enamel, nature has combined both properties with outstanding success - despite a limited number of available constituents. Made up of brittle mineral crystals arranged in a sophisticated hierarchical microstructure, enamel exhibits high stiffness and excellent toughness. Different species exhibit a variety of structural adaptations on varying scales in their dental enamel which optimise not only fracture toughness, but also hardness and abrasion behaviour. Nature's materials still outperform their synthetic counterparts due to these complex structure-property relationships that are not yet fully understood. By analysing structure variations and the underlying mechanical mechanisms systematically, design principles which are the key for the development of advanced synthetic materials uniting high strength and toughness can be formulated. STATEMENT OF SIGNIFICANCE: Dental enamel is a hard protective tissue that combines high strength with an exceptional resistance to catastrophic fracture, properties that in classical materials are commonly found to be mutually exclusive. The biological material is able to outperform its synthetic counterparts due to a sophisticated hierarchical microstructure. Between different species, microstructural adaptations can vary significantly. In this contribution, the different types of dental enamel present in different species are reviewed and connections between microstructure and (mechanical) properties are drawn. By consolidating available information for various species and reviewing it from a materials science point of view, design principles for the development of advanced biomimetic materials uniting high strength and toughness can be formulated.

Quantitative determination of type A and type B carbonate in human deciduous and permanent enamel by means of Fourier transform infrared spectrometry.

Caries progression has been shown to be faster in the deciduous than in the permanent dentition. Several factors influence caries progression. Among these are variations in the chemical composition of the two enamel types. The carbonate ion is known to occupy two different positions in the hydroxyapatite structure of the enamel, the hydroxide position (A) and the phosphate position (B). Carbonate may be of different chemical importance in the two lattice positions. In the present study, a quantitative determination of the carbonate in the two different positions (type A and type B) in deciduous and permanent enamel was performed by FTIR spectrometry. Calibration curves, made with synthesized hydroxyapatites with carbonates in either position, were used to determine the quantity of type A and type B carbonates in both enamel types. The deciduous enamel contained significantly more type A carbonate than permanent enamel. The total carbonate content (sum of type A and type B carbonates) was also significantly higher in deciduous than in permanent enamel. TG analysis of enamel samples confirmed the quantitative carbonate determinations by FTIR spectrometry. The difference in carbonate content between deciduous and permanent enamel may be one of several factors contributing to faster caries progression in deciduous teeth.