Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Publication year range
1.
Horm Metab Res ; 53(10): 654-661, 2021 Oct.
Article in English | MEDLINE | ID: mdl-34517416

ABSTRACT

The clinical characteristics of patients with postoperative hypoparathyroidism who recover parathyroid function more than 12 months after surgery have not been studied. We aimed to evaluate whether the intensity of replacement therapy with calcium and calcitriol is related to the late recovery of parathyroid function. We compared the demographic, surgical, pathological, and analytical features of two groups of patients: cases, i. e., late recovery patients (those who recover parathyroid function>1 year after thyroidectomy, n=40), and controls, i. e., patients with permanent hypoparathyroidism (n=260). Replacement therapy with calcium and calcitriol was evaluated at discharge of surgery, 3-6 months, 12 months, and last visit. No significant differences were found in clinical, surgical, pathological, or analytical characteristics between cases and controls. The proportion of cases who required treatment with calcium plus calcitriol at 12 months was significantly lower than that found in controls (p<0.001). Furthermore, daily calcium and calcitriol doses in controls were significantly higher than those in cases at 3-6 months (p=0.014 and p=0.004, respectively) and at 12 months (p<0.001 and p=0.043, respectively). In several models of logistic regression analysis therapy with calcium and calcitriol at 12 months was negatively related to late recovery of parathyroid function. Although delayed recuperation of parathyroid function after total thyroidectomy is uncommon (13%), follow-up beyond 12 months is necessary in patients with postoperative hypoparathyroidism, especially in those whose needs of treatment with Ca and calcitriol are reducing over time.


Subject(s)
Hypoparathyroidism/rehabilitation , Parathyroid Glands/physiopathology , Thyroidectomy/adverse effects , Adult , Case-Control Studies , Female , Follow-Up Studies , Humans , Hypoparathyroidism/etiology , Hypoparathyroidism/physiopathology , Male , Middle Aged , Postoperative Complications/physiopathology , Postoperative Complications/rehabilitation , Recovery of Function/physiology , Retrospective Studies , Spain , Thyroidectomy/rehabilitation , Time Factors
2.
J Addict Med ; 5(4): 300-1, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21817918

ABSTRACT

Here we present a case of a coincidence of addiction to "Kratom" (botanically known as Mitragyna speciosa Korth) and developed severe primary hypothyroidism. We are discussing a possibility that high dose of indole alkaloid mitragynine (the major alkaloid identified from "Kratom") might reduce the normal response of the thyroid gland to thyroid-stimulating hormone resulting in primary hypothyroidism. Further experimental investigations of mitragynine as a possible suppressor of thyroid gland function would be a matter of interest.


Subject(s)
Hypoparathyroidism/epidemiology , Mitragyna/adverse effects , Plant Extracts/adverse effects , Secologanin Tryptamine Alkaloids/adverse effects , Substance-Related Disorders/epidemiology , Adult , Buprenorphine/therapeutic use , Comorbidity , Drug Therapy, Combination , Humans , Hypoparathyroidism/rehabilitation , Male , Opiate Substitution Treatment , Substance-Related Disorders/rehabilitation , Thyroxine/therapeutic use
3.
Klin Padiatr ; 205(2): 116-8, 1993.
Article in German | MEDLINE | ID: mdl-8487478

ABSTRACT

We report on a 2-year old boy with the characteristic features of Di George syndrome. The diagnosis was confirmed by history, biochemical, immunologic and radiologic findings. After physical exercise he developed an unilateral epiphysiolysis capitis femoris, rarely seen in this age and not known to be a complication of hypoparathyroidism.


Subject(s)
DiGeorge Syndrome/complications , Epiphyses, Slipped/etiology , Hip Dislocation/etiology , Hypoparathyroidism/complications , Cerebral Palsy/complications , Cerebral Palsy/rehabilitation , Child, Preschool , DiGeorge Syndrome/rehabilitation , Humans , Hypoparathyroidism/rehabilitation , Male
SELECTION OF CITATIONS
SEARCH DETAIL
...