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J Med Primatol ; 46(6): 364-367, 2017 12.
Article in English | MEDLINE | ID: mdl-28671330

ABSTRACT

Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque.


Subject(s)
Cytomegalovirus/isolation & purification , Hypophysitis/immunology , Immunocompromised Host , Macaca mulatta , Opportunistic Infections/immunology , Simian Acquired Immunodeficiency Syndrome/complications , Animals , Female , Hypophysitis/complications , Hypophysitis/virology , Opportunistic Infections/complications , Opportunistic Infections/virology , Simian Immunodeficiency Virus/physiology
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