[The role and place of central mediators and peptide bioregulators in the pathogenesis of emotional disorders in neurotic patients]. / Rol' i mesto tsentral'nykh mediatorov i peptidnykh bioreguliatorov v patogeneze émotsional'nykh narushenii u bol'nykh nevrozom.

The accumulated evidence on central mediators indicates that they may play an important part in the maintenance of emotional activity. Their significance is also great in the pathogenesis of affective disorders, including endogenous psychoses and borderline states. But further work in this area is needed relative to interrelation of the above mediators to a new class of bioregulators, viz peptide regulators. The results obtained suggest the existence of differentiated brain mechanisms of formation of emotional disturbances in different forms of neurosis that provide criteria for the diagnosis thereof and differential diagnosis and should be considered in conducting an adequate pathogenetically validated therapy.

[The nature of the neurohormonal reorganizations in patients with neuroses]. / Kharakter neirogormonal'nykh perestroek u bol'nykh nevrozami.

Neurohormonal balance was studied in patients suffering from neurasthenic, hysteric of obsessive-phobic neuroses. The peculiarities of functional restructuring in sympathoadrenal, opioid and pituitary-adrenal cortex systems were considered as related to clinical form or stage of the disease. Irrespective of the neurosis clinical form, a considerable rise in the endorphin blood levels with increasing sympathoadrenal and adrenocortical activities were typical of its initial stages. With long-lasting neuroses, the neurohormonal shifts characteristic of chronic emotional stress were detected.

[Various aspects of the pathogenesis and treatment of hysterical neurosis and hysterical neurotic personality development]. / Nekotorye aspekty patogeneza i terapii istericheskogo nevroza i istericheskogo nevroticheskogo razvitiia lichnosti.

The authors studied 53 patients with hysterical neurosis and 66 with hysterical neurotic development of personality. Factors contributing to an unfavourable course of neurosis and its transformation into a hysterical development were elicited; clinical variants of the formation of the hysterical neurotic personality development are described. A study was carried out aimed at comparing the functions of the serotoninergic and cholinergic systems in patients with hysterical neurosis, hysterical development and hysteroid psychopathy at the stage of decompensation. An increase in the changes in these systems in the "neurosis-development-psychopathy" series and their time-course were defined in the process of treatment. On the basis of the clinical and laboratory data, a conclusion was drawn about the advantage of treating the hysterical development with phenothiazine drugs as compared with tranquilizers.