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1.
Nat Prod Res ; 34(8): 1175-1179, 2020 Apr.
Article in English | MEDLINE | ID: mdl-30773907

ABSTRACT

Coronaridine (1) was isolated from the CH2Cl2 root extract of Tabernaemontana ternifolia. The structure of 1 was established from 1D- and 2D-NMR and HR-ESIMS experiments, and by comparison with reported spectroscopic data. To date, this is the first report of compound 1 from T. ternifolia, introduced as new Tabernaemontana species from Philippines in 2005 on the basis of morphological characters. Coronaridine, an iboga-type indole alkaloid, has been isolated from over 50 Tabernaemontana species and can thus be inferred as a chemotaxonomic marker of the genus. T. ternifolia has a distinct arrangement of leaves not known in the genus, but is variable in other genera. Its isolation from endemic T. ternifolia establishes its position in the genus and supports the claim that coronaridine is a chemical marker of the genus Tabernaemontana. Interestingly, coronaridine exhibited relatively weak activity against Mycobacterium tuberculosis H37Rv (MIC 82.64 µg/mL) (Rifampicin MIC 0.05 µg/mL).


Subject(s)
Antitubercular Agents/pharmacology , Indole Alkaloids/isolation & purification , Tabernaemontana/chemistry , Antitubercular Agents/isolation & purification , Classification , Ibogaine/analogs & derivatives , Ibogaine/isolation & purification , Indole Alkaloids/chemistry , Mycobacterium tuberculosis/drug effects , Plant Leaves/anatomy & histology
2.
Chem Biodivers ; 16(7): e1900175, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31095891

ABSTRACT

Several species from the Apocynaceae family, such as Tabernanthe iboga, Voacanga africana, and many Tabernaemontana species, produce ibogan type alkaloids, some of which present antiaddictive properties. In this study, we used gas chromatography/mass spectrometry (GC/MS) to examine the efficiency of methanol, acetone, ethyl acetate, dichloromethane, chloroform, and hydrochloric acid in extracting the antiaddictive compounds coronaridine, ibogamine, voacangine, and ibogaine (altogether the CIVI-complex) from the root barks of Tabernaemontana alba and Tabernaemontana arborea. These Mexican species have recently shown great potential as alternative natural sources of the aforementioned substances. Methanol proved to be the most suitable solvent. Furthermore, the crude methanolic extracts could be engaged in a one-step demethoxycarbonylation process that converted coronaridine and voacangine directly into its non-carboxylic counterparts ibogamine and ibogaine, respectively, without the intermediacy of their carboxylic acids. The established protocol straightforwardly simplifies the alkaloid mixture from four to two majority compounds. In summary, our findings facilitate and improve both the qualitative and quantitative analysis of CIVI-complex-containing plant material, as well as outlining a viable method for the bulk production of these scientifically and pharmaceutically important substances from Mexican Tabernaemontana species.


Subject(s)
Bridged-Ring Compounds/isolation & purification , Ibogaine/analogs & derivatives , Ibogaine/isolation & purification , Tabernaemontana/chemistry , Bridged-Ring Compounds/chemistry , Ibogaine/chemistry , Mexico , Molecular Conformation , Plant Bark/chemistry , Plant Roots/chemistry , Species Specificity
3.
Nat Prod Res ; 33(23): 3459-3463, 2019 Dec.
Article in English | MEDLINE | ID: mdl-29852800

ABSTRACT

One known bis-indole alkaloid-voacamine was isolated from Voacanga africana Stapf and Surface Plasmon Resonance imaging (SPRi) exprement showed that this alkaloid could be combine with Protein Tyrosine Phosphatase1B (PTP1B). Then the PTP1B activity inhibition experiment display that the compound showed an outstanding promoting activity to PTP1B.


Subject(s)
Ibogaine/analogs & derivatives , Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors , Surface Plasmon Resonance/methods , Voacanga/chemistry , Alkaloids/isolation & purification , Alkaloids/pharmacology , Humans , Ibogaine/isolation & purification , Indoles
4.
Biochem Pharmacol ; 138: 19-30, 2017 08 15.
Article in English | MEDLINE | ID: mdl-28483460

ABSTRACT

Indole alkaloids possess a large spectrum of biological activities including anti-protozoal action. Here we report for the first time that voacamine, isolated from the plant Tabernaemontana coronaria, is an antiprotozoal agent effective against a large array of trypanosomatid parasites including Indian strain of Leishmania donovani and Brazilian strains of Leishmania amazonensis and Trypanosoma cruzi. It inhibits the relaxation activity of topoisomerase IB of L. donovani (LdTop1B) and stabilizes the cleavable complex. Voacamine is probably the first LdTop1B-specific poison to act uncompetitively. It has no impact on human topoisomerase I and II up to 200µM concentrations. The study also provides a thorough insight into ultrastructural alterations induced in three kinetoplastid parasites by a specific inhibitor of LdTop1B. Voacamine is also effective against intracellular amastigotes of different drug unresponsive field isolates of Leishmania donovani obtained from endemic zones of India severely affected with visceral leishmaniasis. Most importantly, this is the first report demonstrating the efficacy of a compound to reduce the burden of drug resistant parasites, unresponsive to SAG, amphotericin B and miltefosine, in experimental BALB/c mice model of visceral leishmaniasis. The findings cumulatively provide a strong evidence that voacamine can be a promising drug candidate against trypanosomatid infections.


Subject(s)
Antiprotozoal Agents/pharmacology , DNA Topoisomerases, Type I/metabolism , Ibogaine/analogs & derivatives , Leishmania donovani/drug effects , Leishmania mexicana/drug effects , Topoisomerase I Inhibitors/pharmacology , Trypanosoma cruzi/drug effects , Animals , Antiprotozoal Agents/administration & dosage , Antiprotozoal Agents/isolation & purification , Antiprotozoal Agents/therapeutic use , Cell Shape/drug effects , DNA Topoisomerases, Type I/chemistry , DNA Topoisomerases, Type I/genetics , Dose-Response Relationship, Drug , Drug Resistance, Multiple , Enzyme Stability/drug effects , Female , Ibogaine/administration & dosage , Ibogaine/isolation & purification , Ibogaine/pharmacology , Ibogaine/therapeutic use , Leishmania donovani/enzymology , Leishmania donovani/growth & development , Leishmania donovani/ultrastructure , Leishmania mexicana/enzymology , Leishmania mexicana/growth & development , Leishmania mexicana/ultrastructure , Leishmaniasis, Visceral/drug therapy , Leishmaniasis, Visceral/parasitology , Lethal Dose 50 , Mice, Inbred BALB C , Microscopy, Electron, Scanning , Microscopy, Electron, Transmission , Plant Bark/chemistry , Protein Subunits/antagonists & inhibitors , Protein Subunits/genetics , Protein Subunits/metabolism , Recombinant Proteins/chemistry , Recombinant Proteins/metabolism , Tabernaemontana/chemistry , Topoisomerase I Inhibitors/administration & dosage , Topoisomerase I Inhibitors/isolation & purification , Topoisomerase I Inhibitors/therapeutic use , Trypanosoma cruzi/enzymology , Trypanosoma cruzi/growth & development , Trypanosoma cruzi/ultrastructure
5.
Nat Prod Res ; 30(10): 1144-9, 2016.
Article in English | MEDLINE | ID: mdl-26140390

ABSTRACT

A new monoterpenoid indole alkaloid compound (1) and six known monoterpenoid indole alkaloids compounds (2-7) were isolated from the barks of Voacanga africana Staph. The structures were established by spectral analysis as ibogamine-16-carboxylic acid,17,20-didehydro-5,6-dioxo-10-methoxy-methyl ester (1), voacamine (2), vobasine (3), voacangine (4), voacristine (5), 19-epi-voacristine (6) and 19-epi-heyneanine (7). Compound 1 was confirmed by X-ray crystallographic analysis. All of the isolated compounds were evaluated for cytotoxicity against five cell lines (HEPG-2, A375, MDA-MB-231, SH-SY5Y, CT26). Among them, compounds 2 and 6 displayed significant inhibitory activities, compounds 3, 4 and 5 showed moderate inhibitory activities, while compounds 1 and 7 showed no inhibitory activities against the five cell lines.


Subject(s)
Antineoplastic Agents, Phytogenic/pharmacology , Secologanin Tryptamine Alkaloids/isolation & purification , Secologanin Tryptamine Alkaloids/pharmacology , Voacanga/chemistry , Antineoplastic Agents, Phytogenic/isolation & purification , Bridged-Ring Compounds/isolation & purification , Bridged-Ring Compounds/pharmacology , Cell Line, Tumor/drug effects , Humans , Ibogaine/analogs & derivatives , Ibogaine/isolation & purification , Indole Alkaloids/isolation & purification , Molecular Structure , Plant Bark/chemistry
6.
Bioorg Med Chem Lett ; 25(18): 3937-40, 2015 Sep 15.
Article in English | MEDLINE | ID: mdl-26231157

ABSTRACT

Four alkaloids, voacangine (1), isovoacangine (2), coronaridine (3), and coronaridine hydroxyindolenine (4), were isolated from the MeOH extract of Tabernaemontana divaricata aerial parts by activity-guided fractionation for Wnt signal inhibitory activity. Compounds 1-4 exhibited TCF/ß-catenin inhibitory activities with IC50 values of 11.5, 6.0, 5.8, and 7.3 µM, respectively. Of these, coronaridine (3) decreased ß-catenin levels in SW480 colon cancer cells, while this decrease in ß-catenin was not suppressed by a co-treatment with 3 and MG132, a proteasome inhibitor. These results suggested that the decrease observed in ß-catenin levels by coronaridine (3) did not depend on a proteasomal degradation process. On the other hand, the treatment of SW480 cells with coronaridine (3) caused a decrease in ß-catenin mRNA levels. Thus, coronaridine (3) may inhibit the Wnt signaling pathway by decreasing the mRNA expression of ß-catenin.


Subject(s)
Down-Regulation/drug effects , Ibogaine/analogs & derivatives , RNA, Messenger/biosynthesis , Tabernaemontana/chemistry , Wnt Signaling Pathway/drug effects , Wnt Signaling Pathway/genetics , beta Catenin/genetics , Cell Line, Tumor , Dose-Response Relationship, Drug , Humans , Ibogaine/chemistry , Ibogaine/isolation & purification , Ibogaine/pharmacology , Molecular Conformation , RNA, Messenger/genetics , Structure-Activity Relationship
7.
J Nat Prod ; 77(8): 1839-46, 2014 Aug 22.
Article in English | MEDLINE | ID: mdl-25093992

ABSTRACT

Seven new iboga-type alkaloids, ervaoffines A-D (1-4), (7S)-3-oxoibogaine hydroxyindolenine (5), ibogaine-5,6-dione (6), and 19-epi-5-oxovoacristine (7), and 10 known alkaloids were isolated from Ervatamia officinalis. The absolute configurations of 1-7 were determined through X-ray diffraction and electronic circular dichroism (ECD) analyses. Ervaoffines A and B represent the first iboga-type pseudoindoxyl alkaloids in which the C-2 spiro carbon configuration is opposite to that of other members of this class, such as iboluteine (8). The relationship between the absolute configuration of the spiro carbons and the Cotton effect in the ECD spectrum is established for the first time for iboga-type pseudoindoxyl and oxindole alkaloids. Additionally, a plausible biogenetic pathway for these alkaloids is proposed.


Subject(s)
Drugs, Chinese Herbal/isolation & purification , Ibogaine/isolation & purification , Indole Alkaloids/isolation & purification , Tabernaemontana/chemistry , Circular Dichroism , Crystallography, X-Ray , Drugs, Chinese Herbal/chemistry , Ibogaine/chemistry , Indole Alkaloids/chemistry , Molecular Conformation , Molecular Structure
8.
J Nat Prod ; 77(8): 1831-8, 2014 Aug 22.
Article in English | MEDLINE | ID: mdl-25052206

ABSTRACT

The iboga alkaloid voacangine (1) has been reported previously to be the first stimulus-selective TRPM8 antagonist. In the present report, a structure-activity relationship (SAR) study is described on the effects of some naturally occurring indole alkaloid analogues on TRPM8 inhibition. Dihydrocatharanthine (10) and catharanthine (11) were found to be inhibitors of TRPM8 activity, and their IC50 values were equivalent to that of BCTC, a potent and representative TRPM8 antagonist. Furthermore, it was shown that the iboga moiety is the most crucial unit for TRPM8 blockade and that its stereostructure, as found in 1 but not in 10 and 11, is essential for chemical agonist-selective TRPM8 inhibition. These findings should provide useful information for synthesizing additional stimulus-selective and TRPM8-selective blockers.


Subject(s)
Ibogaine/analogs & derivatives , Indole Alkaloids/isolation & purification , Indole Alkaloids/pharmacology , TRPM Cation Channels/antagonists & inhibitors , Tabernaemontana/chemistry , Ibogaine/chemistry , Ibogaine/isolation & purification , Ibogaine/pharmacology , Indole Alkaloids/chemistry , Inhibitory Concentration 50 , Molecular Structure , Pyrazines/pharmacology , Pyridines/pharmacology , Structure-Activity Relationship , TRPM Cation Channels/agonists
9.
J Ethnopharmacol ; 155(1): 830-40, 2014 Aug 08.
Article in English | MEDLINE | ID: mdl-24971794

ABSTRACT

ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer׳s disease (AD) neuropathology is strongly associated with the activation of inflammatory pathways, and long-term use of anti-inflammatory drugs reduces the risk of developing the disease. In S. Tomé e Príncipe (STP), several medicinal plants are used both for their positive effects in the nervous system (treatment of mental disorders, analgesics) and their anti-inflammatory properties. The goal of this study was to determine whether a phenotypic, cell-based screening approach can be applied to selected plants from STP (Voacanga africana, Tarenna nitiduloides, Sacosperma paniculatum, Psychotria principensis, Psychotria subobliqua) in order to identify natural compounds with multiple biological activities of interest for AD therapeutics. MATERIALS AND METHODS: Plant hydroethanolic extracts were prepared and tested in a panel of phenotypic screening assays that reflect multiple neurotoxicity pathways relevant to AD-oxytosis in hippocampal nerve cells, in vitro ischemia, intracellular amyloid toxicity, inhibition of microglial inflammation and nerve cell differentiation. HPLC fractions from the extract that performed the best in all of the assays were tested in the oxytosis assay, our primary screen, and the most protective fraction was analyzed by mass spectrometry. The predominant compound was purified, its identity confirmed by ESI mass spectrometry and NMR, and then tested in all of the screening assays to determine its efficacy. RESULTS: An extract from the bark of Voacanga africana was more protective than any other plant extract in all of the assays (EC50s≤2.4 µg/mL). The HPLC fraction from the extract that was most protective against oxytosis contained the alkaloid voacamine (MW=704.90) as the predominant compound. Purified voacamine was very protective at low doses in all of the assays (EC50s≤3.4 µM). CONCLUSION: These findings validate the use of our phenotypic screening, cell-based assays to identify potential compounds to treat AD from plant extracts with ethnopharmacological relevance. Our study identifies the alkaloid voacamine as a major compound in Voacanga africana with potent neuroprotective activities in these assays.


Subject(s)
Ibogaine/analogs & derivatives , Neuroprotective Agents/pharmacology , Plant Extracts/pharmacology , Plants, Medicinal/chemistry , Alzheimer Disease/drug therapy , Alzheimer Disease/physiopathology , Animals , Atlantic Islands , Chromatography, High Pressure Liquid/methods , Dose-Response Relationship, Drug , Ethnopharmacology , Humans , Ibogaine/administration & dosage , Ibogaine/isolation & purification , Ibogaine/pharmacology , Magnetic Resonance Spectroscopy , Medicine, African Traditional/methods , Mice , Neuroprotective Agents/administration & dosage , Neuroprotective Agents/isolation & purification , Plant Extracts/administration & dosage , Rats , Spectrometry, Mass, Electrospray Ionization
10.
J Nat Prod ; 77(2): 285-97, 2014 Feb 28.
Article in English | MEDLINE | ID: mdl-24484240

ABSTRACT

Voacangine (1) is an alkaloid found in the root bark of Voacanga africana. Our previous work has suggested that 1 is a novel transient receptor potential vanilloid type 1 (TRPV1) antagonist. In this study, the agonist and antagonist activities of 1 were examined against thermosensitive TRP channels. Channel activity was evaluated mainly using TRP channel-expressing HEK cells and calcium imaging. Herein, it was shown that 1 acts as an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50, 8 µM). The compound competitively blocked capsaicin binding to TRPV1 (IC50, 50 µM). Voacangine (1) competitively inhibited the binding of menthol to TRPM8 (IC50, 9 µM), but it showed noncompetitive inhibition against icilin (IC50, 7 µM). Moreover, the compound selectively abrogated chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Among these effects, the TRPM8 inhibition profile is unique and noteworthy, because to date no studies have reported a menthol competitive inhibitor of TRPM8 derived from a natural source. Furthermore, this is the first report of a stimulus-selective TRPM8 antagonist. Accordingly, 1 may contribute to the development of a novel class of stimulus-selective TRPM8 blockers.


Subject(s)
Alkaloids/pharmacology , Ibogaine/analogs & derivatives , Transient Receptor Potential Channels/agonists , Transient Receptor Potential Channels/antagonists & inhibitors , Voacanga/chemistry , Africa , Alkaloids/chemistry , Alkaloids/isolation & purification , Calcium/metabolism , Capsaicin/pharmacology , Humans , Ibogaine/chemistry , Ibogaine/isolation & purification , Ibogaine/pharmacology , Menthol/pharmacology , Molecular Structure , Plant Bark/chemistry , Pyrimidinones/pharmacology , TRPV Cation Channels , Transient Receptor Potential Channels/metabolism , Trees/chemistry
11.
Phytomedicine ; 20(6): 543-8, 2013 Apr 15.
Article in English | MEDLINE | ID: mdl-23375813

ABSTRACT

Guided by the acetylcholinesterase inhibiting activity, the bisindole alkaloid 3'-R/S-hydroxyvoacamine was isolated from a stem extract of Tabernaemontana divaricata, a plant used in Thailand in traditional rejuvenation remedies for improving the memory. The structure of the alkaloid was elucidated by extensive use of NMR spectroscopy and the complete assignment of the (1)H and (13)C NMR spectra is reported. The alkaloid acted as a non-competitive inhibitor against AChE with an IC50 value of 7.00±1.99 µM. An HPLC method was developed for the quantitative analysis of the AChE inhibitor. It suggested that there was 12.4% (w/w) of 3'-R/S-hydroxyvoacamine in the alkaloid enriched fraction of T. divaricata stem.


Subject(s)
Acetylcholinesterase/metabolism , Cholinesterase Inhibitors/pharmacology , Ibogaine/analogs & derivatives , Plant Extracts/pharmacology , Tabernaemontana/chemistry , Cholinesterase Inhibitors/chemistry , Cholinesterase Inhibitors/isolation & purification , Humans , Ibogaine/chemistry , Ibogaine/isolation & purification , Ibogaine/pharmacology , Inhibitory Concentration 50 , Molecular Structure , Plant Extracts/chemistry
12.
Zhong Yao Cai ; 35(2): 226-9, 2012 Feb.
Article in Chinese | MEDLINE | ID: mdl-22822667

ABSTRACT

OBJECTIVE: To study the alkaloids of Voacanga africana. METHODS: The alkaloids were isolated by normal phase silica gel and Sephadex LH-20 column chromatography. Their structures were elucidated by analysis of spectroscopic data. RESULTS: Eight alkaloids were isolated and their structures were elucidated as voacangine(1), voacangine hydroxyindolenine(2), 19R-epi-voacristine(3), epi-ibogaine(4), vobasine(5), 19-epi-heyneanine(6), vobtusine(7) and voacamine(8). CONCLUSION: Compounds 2-4 and 6 are isolated from this plant for the first time.


Subject(s)
Alkaloids/chemistry , Voacanga/chemistry , Alkaloids/isolation & purification , Ibogaine/analogs & derivatives , Ibogaine/chemistry , Ibogaine/isolation & purification , Magnetic Resonance Spectroscopy , Plant Bark/chemistry , Plant Roots/chemistry , Plant Stems/chemistry
13.
Yao Xue Xue Bao ; 45(4): 471-4, 2010 Apr.
Article in Chinese | MEDLINE | ID: mdl-21355212

ABSTRACT

Catharanthus roseus (L.) G. Don is a plant of the Catharanthus genus of Apocynaceae which has been reported to have therapeutic effects of detoxication and anticancer. In order to further study the alkaloid constituents of C. roseus, the aerial parts of the plant were extracted with 95% EtOH, and then treated with 2% H2SO4 and NH3H2O to obtain total alkaloids. The total alkaloids were separated and purified by column chromatography over silica gel and prepared by high performance liquid chromatography (HPLC). Their structures were elucidated on the basis of physicochemical properties and spectral data. A new alkaloid together with five known compounds were isolated and identified as vindolinine B (1), lochnericine (2), horhammericine (3), vindorosine (4), vindoline (5), and coronaridine (6). Compound 1 is a new compound and named as vindolinine B.


Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Catharanthus/chemistry , Indole Alkaloids/isolation & purification , Plants, Medicinal/chemistry , Antineoplastic Agents, Phytogenic/chemistry , Ibogaine/analogs & derivatives , Ibogaine/chemistry , Ibogaine/isolation & purification , Indole Alkaloids/chemistry , Molecular Structure , Plant Components, Aerial/chemistry , Vinblastine/analogs & derivatives , Vinblastine/chemistry , Vinblastine/isolation & purification
14.
Zhongguo Zhong Yao Za Zhi ; 32(13): 1296-9, 2007 Jul.
Article in Chinese | MEDLINE | ID: mdl-17879729

ABSTRACT

OBJECTIVE: To investigate the chemical constituents of the rhizome of Ervatamia hainanensis. METHOD: The solvent extraction and silica column chromatography were used to separate the chemical constituents, and their structures were identified by physico chemical properties and spectra analysis. RESULT: Twelve compounds were isolated and their structures were identified as voacangine (1), ibogaine (2), ibogamine (3), coronaridine (4), 19-heyneanine (5), 19-epi-heyneanine (6), 3-hydroxyl coronaridine (7), coronaridine hydroxyindolenine (8), 3-(2-oxopropyl) coronaridine (9), vobasine (10), alpha-amyrin (11), alpha-amyrin acetate (12). CONCLUSION: Compounds 1, 2, 6, 11 and 12 were first found from this plant.


Subject(s)
Apocynaceae/chemistry , Ibogaine/analogs & derivatives , Ibogaine/isolation & purification , Oleanolic Acid/analogs & derivatives , Chromatography, Gel , Ibogaine/chemistry , Oleanolic Acid/chemistry , Oleanolic Acid/isolation & purification , Plants, Medicinal/chemistry , Rhizome/chemistry
15.
Chem Biodivers ; 1(4): 646-56, 2004 Apr.
Article in English | MEDLINE | ID: mdl-17191876

ABSTRACT

Six new indole alkaloids, viz., (3S)-3-cyanocoronaridine (2), (3S)-3-cyanoisovoacangine (3), conolobine A (5), conolobine B (6), conolidine (7), and (3R/3S)-3-ethoxyvoacangine (8), in addition to 36 known ones, were obtained from the stem-bark extract of the Malayan Tabernaemontana divaricata. The structures were determined by NMR and MS analysis. The CN-substituted alkaloids showed appreciable cytotoxicity towards the KB human oral epidermoid carcinoma cell-line.


Subject(s)
Ibogaine/chemistry , Ibogaine/toxicity , Tabernaemontana , Cell Line, Tumor , Humans , Ibogaine/isolation & purification , Indole Alkaloids/chemistry , Indole Alkaloids/isolation & purification , Indole Alkaloids/toxicity , Plant Bark , Plant Extracts/chemistry , Plant Extracts/isolation & purification , Plant Extracts/toxicity , Plant Stems
16.
J Nat Prod ; 57(11): 1517-22, 1994 Nov.
Article in English | MEDLINE | ID: mdl-7853002

ABSTRACT

Coronaridine [1], conoduramine [2], and voacamine [3], three indole alkaloids isolated from Peschiera laeta, have been found to enhance the cytotoxic response mediated by vinblastine [4] with multidrug-resistant KB cells. Inhibition of vinblastine binding with membrane vesicles isolated from this cell line was also assessed, and the bisindole alkaloids conoduramine [2] and voacamine [3] were found to be more potent inhibitory agents than the monomeric alkaloid, coronaridine [1]. Thus, these compounds appear to function by binding with P-glycoprotein.


Subject(s)
Alkaloids/toxicity , Antineoplastic Agents/toxicity , Cell Survival/drug effects , Drug Resistance, Multiple , Ibogaine/analogs & derivatives , Trees , Vinblastine/toxicity , Alkaloids/chemistry , Alkaloids/isolation & purification , Drug Synergism , Humans , Ibogaine/isolation & purification , Ibogaine/toxicity , KB Cells
17.
J Ethnopharmacol ; 14(2-3): 315-8, 1985.
Article in English | MEDLINE | ID: mdl-4094474

ABSTRACT

From the stembark of Tabernaemontana crassa the alkaloid ibogaine was isolated as the major component. Ibogaine showed activity against the gram-positive Bacillus subtilis. Conopharyngine was identified as one of the minor compounds.


Subject(s)
Alkaloids/isolation & purification , Ibogaine/isolation & purification , Plants, Medicinal/analysis , Alkaloids/pharmacology , Bacteria/drug effects , Chemical Phenomena , Chemistry , Chromatography, Thin Layer , Ibogaine/pharmacology , Microbial Sensitivity Tests
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