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Mild and safe procedure for hydrolyzing oximes: improved synthesis of 1,2-indandione.

Gupta, S K; Marathe, S A.

J Pharm Sci ; 65(1): 134-5, 1976 Jan.

Article in English | MEDLINE | ID: mdl-1255419

ABSTRACT

Four ketoximes were hydrolyzed to the corresponding ketones in 66-91% yields using 75% sulfuric acid and 37% formaldehyde at room temperature. An earlier procedure involving hydrochloric acid and 37% formaldehyde is extremely hazardous because it leads to the formation of bis(chloromethyl) ether, a potent carcinogen.

Subject(s)

Indans/biosynthesis , Indenes/biosynthesis , Hydrolysis , Methods , Temperature

Degradation of steroids by a Nocardia sp. grown on hydrocarbons or on glucose.

Probst, M; Strijewski, A; Tan, T L; Wagner, F.

Biotechnol Bioeng Symp ; 0(4-1): 217-24, 1973.

Article in English | MEDLINE | ID: mdl-4802440

Subject(s)

Alkanes/metabolism , Glucose/metabolism , Nocardia/metabolism , Pregnenes/metabolism , Progesterone/metabolism , Acids/biosynthesis , Biotransformation , Calcium/pharmacology , Chemical Phenomena , Chemistry , Dimethyl Sulfoxide , Hydrogen-Ion Concentration , Indans/biosynthesis , Iron/pharmacology , Nocardia/growth & development , Propionates/biosynthesis , Secosteroids/biosynthesis

ABSTRACT

Subject(s)

Subject(s)

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